Now showing items 1-4 of 4

    • Genome-wide identification of significant aberrations in cancer genome 

      Yuan, Xiguo; Yu, Guoqiang; Hou, Xuchu; Shih, Ie-Ming; Clarke, Robert; Zhang, Junying; Hoffman, Eric P; Wang, Roger R; Zhang, Zhen; Wang, Yue (2012-07-27)
      Abstract Background Somatic Copy Number Alterations (CNAs) in human genomes are present in almost all human cancers. Systematic efforts to characterize such structural variants must effectively distinguish significant ...
    • Knowledge-fused differential dependency network models for detecting significant rewiring in biological networks 

      Tian, Ye; Zhang, Bai; Hoffman, Eric P; Clarke, Robert; Zhang, Zhen; Shih, Ie-Ming; Xuan, Jianhua; Herrington, David M; Wang, Yue (2014-07-24)
      Modeling biological networks serves as both a major goal and an effective tool of systems biology in studying mechanisms that orchestrate the activities of gene products in cells. Biological networks are context-specific ...
    • Knowledge-guided multi-scale independent component analysis for biomarker identification 

      Chen, Li; Xuan, Jianhua; Wang, Chen; Shih, Ie-Ming; Wang, Yue; Zhang, Zhen; Hoffman, Eric; Clarke, Robert (2008-10-06)
      Abstract Background Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical methods often fail to identify ...
    • Knowledge-guided multi-scale independent component analysis for biomarker identification 

      Chen, Li; Xuan, Jianhua; Wang, Chen; Shih, Ie-Ming; Wang, Yue; Zhang, Zhen; Hoffman, Eric; Clarke, Robert (2008-10-06)
      Abstract Background Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical methods often fail to identify ...