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dc.contributor.authorMurgatroyd, Christopher A.
dc.contributor.authorHicks-Nelson, Alexandria
dc.contributor.authorFink, Alexandria
dc.contributor.authorBeamer, Gillian
dc.contributor.authorGurel, Kursat
dc.contributor.authorElnady, Fawzy
dc.contributor.authorPittet, Florent
dc.contributor.authorNephew, Benjamin C.
dc.date.accessioned2020-09-21T18:57:57Z
dc.date.available2020-09-21T18:57:57Z
dc.date.issued2016-12-14
dc.identifierARTN 155 (Article number)
dc.identifier.issn1664-2392
dc.identifier.urihttp://hdl.handle.net/10919/100049
dc.description.abstractRecent studies support the hypothesis that the adverse effects of early-life adversity and transgenerational stress on neural plasticity and behavior are mediated by inflammation. The objective of the present study was to investigate the immune and behavioral programing effects of intranasal (IN) vasopressin (AVP) and oxytocin (OXT) treatment of chronic social stress (CSS)-exposed F1 dams on F2 juvenile female offspring. It was hypothesized that maternal AVP and OXT treatment would have preventative effects on social stress-induced deficits in offspring anxiety and social behavior and that these effects would be associated with changes in interferon-γ (IFNγ). Control and CSS-exposed F1 dams were administered IN saline, AVP, or OXT during lactation and the F2 juvenile female offspring were assessed for basal plasma IFNγ and perseverative, anxiety, and social behavior. CSS F2 female juvenile offspring had elevated IFNγ levels and exhibited increased repetitive/perseverative and anxiety behaviors and deficits in social behavior. These effects were modulated by AVP and OXT in a context- and behavior-dependent manner, with OXT exhibiting preventative effects on repetitive and anxiety behaviors and AVP possessing preventative effects on social behavior deficits and anxiety. Basal IFNγ levels were elevated in the F2 offspring of OXT-treated F1 dams, but IFNγ was not correlated with the behavioral effects. These results support the hypothesis that maternal AVP and OXT treatment have context- and behavior-specific effects on peripheral IFNγ levels and perseverative, anxiety, and social behaviors in the female offspring of early-life social stress-exposed dams. Both maternal AVP and OXT are effective at preventing social stress-induced increases in self-directed measures of anxiety, and AVP is particularly effective at preventing impairments in overall social contact. OXT is specifically effective at preventing repetitive/perseverative behaviors, yet is ineffective at preventing deficits in overall social behavior.
dc.format.extent11 page(s)
dc.format.mediumElectronic-eCollection
dc.languageEnglish
dc.publisherFrontiers
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectEndocrinology & Metabolism
dc.subjectsocial stress
dc.subjectdepression
dc.subjectdepression and anxiety disorders
dc.subjectinterferon-gamma
dc.subjectoxytocin
dc.subjectvasopressin
dc.subjectsocial behavior
dc.subjectinflammation
dc.subjectV1A RECEPTOR ANTAGONIST
dc.subjectARGININE-VASOPRESSIN
dc.subjectGENE-EXPRESSION
dc.subjectCARE
dc.subjectRATS
dc.subjectDEPRESSION
dc.subjectAGGRESSION
dc.subjectPROLACTIN
dc.subjectANXIETY
dc.subjectCORTICOSTERONE
dc.subjectdepression
dc.subjectdepression and anxiety disorders
dc.subjectinflammation
dc.subjectinterferon-γ
dc.subjectoxytocin
dc.subjectsocial behavior
dc.subjectsocial stress
dc.subjectvasopressin
dc.subject1103 Clinical Sciences
dc.subject1111 Nutrition and Dietetics
dc.titleEffects of Chronic Social Stress and Maternal Intranasal Oxytocin and Vasopressin on Offspring Interferon-gamma and Behavior
dc.typeArticle
dc.date.updated2020-09-21T18:57:54Z
dc.description.versionPublished (Publication status)
dc.title.serialFRONTIERS IN ENDOCRINOLOGY
dc.identifier.doihttps://doi.org/10.3389/fendo.2016.00155
dc.type.otherArticle
dc.type.otherJournal
dc.identifier.volume7
dc.identifier.orcidElnady, Fawzy [0000-0003-4282-7949 (orcid)]
dc.identifier.pmid28018290 (pubmed)
dcterms.dateAccepted2016-11-28
dc.identifier.eissn1664-2392
pubs.organisational-group/Virginia Tech/Veterinary Medicine
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiology
pubs.organisational-group/Virginia Tech


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Creative Commons Attribution 4.0 International
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