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dc.contributor.authorPerlatti, Bruno
dc.contributor.authorNichols, Connie B.
dc.contributor.authorAlspaugh, J. Andrew
dc.contributor.authorGloer, James B.
dc.contributor.authorBills, Gerald F.
dc.date.accessioned2020-10-13T17:15:33Z
dc.date.available2020-10-13T17:15:33Z
dc.date.issued2020-09-26
dc.identifier.citationPerlatti, B.; Nichols, C.B.; Alspaugh, J.A.; Gloer, J.B.; Bills, G.F. Sphaerostilbellins, New Antimicrobial Aminolipopeptide Peptaibiotics from Sphaerostilbella toxica. Biomolecules 2020, 10, 1371.
dc.identifier.urihttp://hdl.handle.net/10919/100466
dc.description.abstractSphaerostilbella toxica is a mycoparasitic fungus that can be found parasitizing wood-decay basidiomycetes in the southern USA. Organic solvent extracts of fermented strains of S. toxica exhibited potent antimicrobial activity, including potent growth inhibition of human pathogenic yeasts Candida albicans and Cryptococcus neoformans, the respiratory pathogenic fungus Aspergillus fumigatus, and the Gram-positive bacterium Staphylococcus aureus. Bioassay-guided separations led to the purification and structure elucidation of new peptaibiotics designated as sphaerostilbellins A and B. Their structures were established mainly by analysis of NMR and HRMS data, verification of amino acid composition by Marfey’s method, and by comparison with published data of known compounds. They incorporate intriguing structural features, including an N-terminal 2-methyl-3-oxo-tetradecanoyl (MOTDA) residue and a C-terminal putrescine residue. The minimal inhibitory concentrations for sphaerostilbellins A and B were measured as 2 μM each for C. neoformans, 1 μM each for A. fumigatus, and 4 and 2 μM, respectively, for C. albicans. Murine macrophage cells were unaffected at these concentrations.en
dc.format.mimetypeapplication/pdf
dc.language.isoenen_US
dc.publisherMDPI
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleSphaerostilbellins, New Antimicrobial Aminolipopeptide Peptaibiotics from Sphaerostilbella toxicaen
dc.typeArticle - Refereeden_US
dc.date.updated2020-10-13T13:24:04Z
dc.title.serialBiomolecules
dc.identifier.doihttps://doi.org/10.3390/biom10101371
dc.type.dcmitypeText
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