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dc.contributor.authorLin, Wenxue
dc.contributor.authorKrebs, Nicolle M.
dc.contributor.authorZhu, Junjia
dc.contributor.authorFoulds, Jonathan
dc.contributor.authorHorn, Kimberly
dc.contributor.authorMuscat, Joshua E.
dc.date.accessioned2020-10-13T17:17:07Z
dc.date.available2020-10-13T17:17:07Z
dc.date.issued2020-09-26
dc.identifier.citationLin, W.; Krebs, N.M.; Zhu, J.; Foulds, J.; Horn, K.; Muscat, J.E. Comparison between Gradual Reduced Nicotine Content and Usual Nicotine Content Groups on Subjective Cigarette Ratings in a Randomized Double-Blind Trial. Int. J. Environ. Res. Public Health 2020, 17, 7047.
dc.identifier.urihttp://hdl.handle.net/10919/100467
dc.description.abstractIn 2018, the United States Food and Drug Administration (FDA) issued an advanced notice of proposed rulemaking to reduce nicotine in tobacco products to produce a minimally addictive or nonaddictive effect, but there was a research gap in the subjective responses of reduced-nicotine-content cigarettes. We compared the responses of the modified cigarette evaluation questionnaire (mCEQ) and cigarette-liking scale (CLS) between the gradually reduced nicotine content (RNC) group and the usual nicotine content (UNC) group. Linear mixed-effects models for repeated measures were used to analyze and compare the change over time for the mCEQ and CLS across the two treatment groups (RNC and UNC). We found that the change over time for the mCEQ and CLS was significant between the RNC and the UNC treatment groups at the beginning of visit 6 with 1.4 mg nicotine/cigarette. At visits 8 and 9, the RNC group reported significantly lower satisfaction scores compared to UNC. Subscale analysis showed that smoking satisfaction decreased in RNC while other measures, such as cigarette enjoyment, did not change. Understanding the impact of nicotine reduction on cigarette subjective responses through evaluation and liking scales would provide valuable information to the FDA on nicotine reduction policies for cigarettes.en
dc.format.mimetypeapplication/pdf
dc.language.isoenen_US
dc.publisherMDPI
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleComparison between Gradual Reduced Nicotine Content and Usual Nicotine Content Groups on Subjective Cigarette Ratings in a Randomized Double-Blind Trialen
dc.typeArticle - Refereeden_US
dc.date.updated2020-10-13T13:24:06Z
dc.contributor.departmentPopulation Health Sciences
dc.title.serialInternational Journal of Environmental Research and Public Health
dc.identifier.doihttps://doi.org/10.3390/ijerph17197047
dc.type.dcmitypeText
dc.type.dcmitypeStillImage


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International