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dc.contributor.authorWang, Ding
dc.contributor.authorLindemann, Merlin D.
dc.contributor.authorEstienne, Mark J.
dc.date.accessioned2020-10-13T17:20:15Z
dc.date.available2020-10-13T17:20:15Z
dc.date.issued2020-10-09
dc.identifier.citationWang, D.; Lindemann, M.D.; Estienne, M.J. Effect of Folic Acid Supplementation and Dietary Protein Level on Growth Performance, Serum Chemistry and Immune Response in Weanling Piglets Fed Differing Concentrations of Aflatoxin. Toxins 2020, 12, 651.
dc.identifier.urihttp://hdl.handle.net/10919/100471
dc.description.abstractEffects of folic acid and protein levels on growth and serum chemistry in pigs fed aflatoxin were determined in two experiments. Increasing aflatoxin (250 to 800 ppb) decreased (P < 0.05) weight gain and feed intake for both of the 35-day trials. In Experiment 1, increasing aflatoxin (0, 250, 500 ppb), increased linearly (P < 0.05) aspartate aminotransferase (AST), alkaline phosphatase (ALKP) and ɣ-glutamyl transferase (GGT). Folic acid (0, 2.0, 5.0, 12.5 ppm) increased linearly (P < 0.05) serum K, Ca, P, Mg, and AST with the largest effect observed at 12.5 ppm. Folic acid decreased (P < 0.05) blood urea nitrogen (BUN): creatinine and Na:K. In Experiment 2, aflatoxin (800 ppb) increased (P < 0.05) glucose and GGT, and decreased (P < 0.05) Na:K and albumin:globulin. Increasing protein from 15 to 18% elevated BUN: creatinine (P < 0.05), albumin: globulin (P < 0.05), albumin (P < 0.05) and ALKP (P < 0.05). Folic acid (2 ppm) elevated (P < 0.05) BUN, and interacted with both aflatoxin (P < 0.10) and protein (P < 0.05) on BUN. Adding folic acid to aflatoxin contaminated diets improved some measures of clinical chemistry in Experiment 1 but not traditional growth performance measures. The higher protein level reduced the effects of aflatoxicosis on growth.en
dc.format.mimetypeapplication/pdf
dc.language.isoenen_US
dc.publisherMDPI
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleEffect of Folic Acid Supplementation and Dietary Protein Level on Growth Performance, Serum Chemistry and Immune Response in Weanling Piglets Fed Differing Concentrations of Aflatoxinen
dc.typeArticle - Refereeden_US
dc.date.updated2020-10-13T13:24:28Z
dc.contributor.departmentAnimal and Food Sciences
dc.title.serialToxins
dc.identifier.doihttps://doi.org/10.3390/toxins12100651
dc.type.dcmitypeText
dc.type.dcmitypeStillImage


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