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dc.contributor.advisorDucker, William A.en_US
dc.contributor.advisorAnderson, Mark R.en_US
dc.contributor.advisorEsker, Alan R.en_US
dc.contributor.advisorMorris, John R.en_US
dc.contributor.advisorTissue, Brian M.en_US
dc.contributor.authorJang, Chang-Hyunen_US
dc.date.accessioned2011-08-22T18:53:12Z
dc.date.available2011-08-22T18:53:12Z
dc.date.issued2003-12-19en_US
dc.identifier.otheretd-01242004-013030en_US
dc.identifier.urihttp://hdl.handle.net/10919/11103
dc.description.abstractThis study describes the covalent and the electrostatic attachment of molecules, nano-particles, and proteins to patterned self-assembled monolayers. A scanning probe nanografting technique was employed to produce patterns of various sizes, down to 10 nm. Thus, we are able to demonstrate a degree of surface patterning which is an order of magnitude smaller than that used in the semiconductor industry. One efficient strategy for creating chemically specific nanostructures is to use the extraordinary catalytic properties of enzymes. However, as the dimension of a catalyst patch is reduced down to nanometer scale, it is difficult to detect the very low concentration of product. This study resolves the problem by developing a new strategy: the surface trapping of a product generated by a nanometer-scale patch of surface-bound enzyme. An array of proteins finds use when the array contains a number of different proteins. Toward this end, a new and convenient method for immobilizing enzymes is developed, which will allow the preparation of thin films containing several different catalytically-active enzymes on the nanoscale. The disadvantage of scanning probe nanografting technique is that the AFM tip loses resolution through wear during the patterning procedure. This study examines the possibility of developing a new AFM lithographic method to avoid wear: the use of enzymes covalently attached to a tip as a site-specific catalyst.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.relation.haspartETD-correct.pdfen_US
dc.rightsThe authors of the theses and dissertations are the copyright owners. Virginia Tech's Digital Library and Archives has their permission to store and provide access to these works.en_US
dc.source.urihttp://scholar.lib.vt.edu/theses/available/etd-01242004-013030en_US
dc.subjectAtomic Force Microscopyen_US
dc.subjectNanofabricationen_US
dc.subjectSelf-Assembled Monolayeren_US
dc.subjectLithographyen_US
dc.subjectAcetylcholinestraseen_US
dc.titleAFM-Assisted Nanofabrication using Self-Assembled Monolayersen_US
dc.typeOther - Dissertationen_US
dc.contributor.departmentChemistryen_US
dc.description.degreePHDen_US


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