AFM-Assisted Nanofabrication using Self-Assembled Monolayers

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dc.contributor.advisor Ducker, William A. en_US
dc.contributor.advisor Anderson, Mark R. en_US
dc.contributor.advisor Esker, Alan R. en_US
dc.contributor.advisor Morris, John R. en_US
dc.contributor.advisor Tissue, Brian M. en_US
dc.contributor.author Jang, Chang-Hyun en_US
dc.date.accessioned 2011-08-22T18:53:12Z
dc.date.available 2011-08-22T18:53:12Z
dc.date.issued 2003-12-19 en_US
dc.identifier.other etd-01242004-013030 en_US
dc.identifier.uri http://hdl.handle.net/10919/11103
dc.description.abstract This study describes the covalent and the electrostatic attachment of molecules, nano-particles, and proteins to patterned self-assembled monolayers. A scanning probe nanografting technique was employed to produce patterns of various sizes, down to 10 nm. Thus, we are able to demonstrate a degree of surface patterning which is an order of magnitude smaller than that used in the semiconductor industry. One efficient strategy for creating chemically specific nanostructures is to use the extraordinary catalytic properties of enzymes. However, as the dimension of a catalyst patch is reduced down to nanometer scale, it is difficult to detect the very low concentration of product. This study resolves the problem by developing a new strategy: the surface trapping of a product generated by a nanometer-scale patch of surface-bound enzyme. An array of proteins finds use when the array contains a number of different proteins. Toward this end, a new and convenient method for immobilizing enzymes is developed, which will allow the preparation of thin films containing several different catalytically-active enzymes on the nanoscale. The disadvantage of scanning probe nanografting technique is that the AFM tip loses resolution through wear during the patterning procedure. This study examines the possibility of developing a new AFM lithographic method to avoid wear: the use of enzymes covalently attached to a tip as a site-specific catalyst. en_US
dc.format.medium ETD en_US
dc.publisher Virginia Tech en_US
dc.relation.haspart ETD-correct.pdf en_US
dc.rights The authors of the theses and dissertations are the copyright owners. Virginia Tech's Digital Library and Archives has their permission to store and provide access to these works. en_US
dc.source.uri http://scholar.lib.vt.edu/theses/available/etd-01242004-013030 en_US
dc.subject Atomic Force Microscopy en_US
dc.subject Nanofabrication en_US
dc.subject Self-Assembled Monolayer en_US
dc.subject Lithography en_US
dc.subject Acetylcholinestrase en_US
dc.title AFM-Assisted Nanofabrication using Self-Assembled Monolayers en_US
dc.type Other - Dissertation en_US
dc.contributor.department Chemistry en_US
dc.description.degree PHD en_US

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