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Experimental determination of the oral bioavailability and bioaccessibility of lead particles

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dc.contributor.author Deshommes, Elise
dc.contributor.author Tardif, Robert
dc.contributor.author Edwards, Marc
dc.contributor.author Sauvé, Sébastien
dc.contributor.author Prévost, Michèle
dc.date.accessioned 2013-01-17T16:04:58Z
dc.date.available 2013-01-17T16:04:58Z
dc.date.issued 2012-11-22
dc.identifier.citation Chemistry Central Journal. 2012 Nov 22;6(1):138
dc.identifier.uri http://dx.doi.org/10.1186/1752-153X-6-138
dc.identifier.uri http://hdl.handle.net/10919/19162
dc.description.abstract Abstract In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.
dc.title Experimental determination of the oral bioavailability and bioaccessibility of lead particles
dc.type Journal Article
dc.date.updated 2013-01-17T16:04:59Z
dc.description.version Peer Reviewed
dc.language.rfc3066 en
dc.rights.holder Elise Deshommes et al.; licensee BioMed Central Ltd.


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  • BioMed Central [327]
    BioMed Central publications by Virginia Tech authors.

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