Browsing Virginia Tech Carilion (VTC) by Issue Date
Now showing items 21-40 of 645
-
Functional brain network changes associated with maintenance of cognitive function in multiple sclerosis
(Frontiers, 2010-11-22)In multiple sclerosis (MS) functional changes in connectivity due to cortical reorganization could lead to cognitive impairment (CI), or reflect a re-adjustment to reduce the clinical effects of widespread tissue damage. ... -
Dynamic Causal Models and Physiological Inference: A Validation Study Using Isoflurane Anaesthesia in Rodents
(PLOS, 2011)Generative models of neuroimaging and electrophysiological data present new opportunities for accessing hidden or latent brain states. Dynamic causal modeling (DCM) uses Bayesian model inversion and selection to infer the ... -
Different Gain/Loss Sensitivity and Social Adaptation Ability in Gifted Adolescents during a Public Goods Game
(PLOS, 2011)Gifted adolescents are considered to have high IQs with advanced mathematical and logical performances, but are often thought to suffer from social isolation or emotional mal-adaptation to the social group. The underlying ... -
Hippocampal Deletion of BDNF Gene Attenuates Gamma Oscillations in Area CA1 by Up-Regulating 5-HT3 Receptor
(PLOS, 2011-01-26)Background: Pyramidal neurons in the hippocampal area CA3 express high levels of BDNF, but how this BDNF contributes to oscillatory properties of hippocampus is unknown. Methodology/Principal Findings: Here we examined ... -
Recapitulation of an ion channel IV curve using frequency components.
(2011-02-08)INTRODUCTION: Presently, there are no established methods to measure multiple ion channel types simultaneously and decompose the measured current into portions attributable to each channel type. This study demonstrates how ... -
Mathematically Gifted Adolescents Have Deficiencies in Social Valuation and Mentalization
(PLOS, 2011-04-04)Many mathematically gifted adolescents are characterized as being indolent, underachieving and unsuccessful despite their high cognitive ability. This is often due to difficulties with social and emotional development. ... -
Methicillin-Susceptible Staphylococcus aureus as a Predominantly Healthcare-Associated Pathogen: A Possible Reversal of Roles?
(PLoS, 2011-04-13)Background
Methicillin-resistant Staphylococcus aureus (MRSA) strains have become common causes of skin and soft tissue infections (SSTI) among previously healthy people, a role of methicillin-susceptible (MSSA) ... -
Interoception drives increased rational decision-making in meditators playing the ultimatum game
(Frontiers, 2011-04-18)Human decision-making is often conceptualized as a competition between cognitive and emotional processes in the brain. Deviations from rational processes are believed to derive from inclusion of emotional factors in ... -
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
(2011-05)Connexin 43 (Cx43) is a gap junction (GJ) protein widely expressed in mammalian tissues that mediates cell-to-cell coupling. Intercellular channels comprising GJ aggregates form from docking of paired connexons, with one ... -
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns
(Rockefeller Univ Press, 2011-05-09) -
Domain expertise insulates against judgment bias by monetary favors through a modulation of ventromedial prefrontal cortex
(NAS, 2011-06-21)Recent work using an art-viewing paradigm shows that monetary sponsorship of the experiment by a company (a favor) increases the valuation of paintings placed next to the sponsoring corporate logo, an effect that correlates ... -
Sub-Second Dopamine Detection in Human Striatum
(PLOS, 2011-08-04)Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the ... -
Alterations in Brain Connectivity Underlying Beta Oscillations in Parkinsonism
(PLOS, 2011-08-11)Cortico-basal ganglia-thalamocortical circuits are severely disrupted by the dopamine depletion of Parkinson’s disease (PD), leading to pathologically exaggerated beta oscillations. Abnormal rhythms, found in several circuit ... -
Computational modeling of interacting VEGF and soluble VEGF receptor concentration gradients
(Frontiers, 2011-10-04)Experimental data indicates that soluble vascular endothelial growth factor (VEGF) receptor 1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by VEGF-A. To better delineate the role of sFlt-1 in ... -
Target-Derived Matricryptins Organize Cerebellar Synapse Formation through _3_1 Integrins
(Cell, 2012)Trans-synaptic organizing cues must be passed between synaptic partners for synapses to properly form. Much of our understanding of this process stems from studies at the neuromuscular junction, where target-derived growth ... -
Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice
(Hindawi, 2012)The cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR). Recent findings indicate that the ... -
Lessons learned from implementing the patient-centered medical home.
(Hindawi, 2012)The Patient-Centered Medical Home (PCMH) is a primary care model that provides coordinated and comprehensive care to patients to improve health outcomes. This paper addresses practical issues that arise when transitioning ... -
MRSA USA300 at Alaska native medical center, Anchorage, Alaska, USA, 2000-2006
(Centers for Disease Control and Prevention, 2012-01)To determine whether methicillin-resistant Staphylococcus aureus (MRSA) USA300 commonly caused infections among Alaska Natives, we examined clinical MRSA isolates from the Alaska Native Medical Center, Anchorage, during ... -
Mucosal Airway Laceration Secondary To Endobronchial Ultrasonography
(Hindawi, 2012-01-01)Endobronchial ultrasound-guided transbronchial needle aspiration is becoming the standard of care for mediastinal sampling to diagnose and stage lung cancer. It is considered to be safe and rivals the gold standard, ... -
Fibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleus
(Frontiers, 2012-01-10)At least three forms of signaling between pre- and postsynaptic partners are necessary during synapse formation. First, “targeting” signals instruct presynaptic axons to recognize and adhere to the correct portion of a ...
