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Gene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivation
(National Academy of Sciences, 2008-07)
The mapping of eye-specific, geniculocortical inputs to primary visual cortex (V1) is highly sensitive to the balance of correlated activity between the two eyes during a restricted postnatal critical period for ocular ...
Remote Excitation of Neuronal Circuits Using Low- Intensity, Low-Frequency Ultrasound
(PLOS, 2008-10-29)
Possessing the ability to noninvasively elicit brain circuit activity yields immense experimental and therapeutic power. Most currently employed neurostimulation methods rely on the somewhat invasive use of stimulating ...
Ready…Go: Amplitude of the fMRI Signal Encodes Expectation of Cue Arrival Time
(PLOS, 2009-08-04)
What happens when the brain awaits a signal of uncertain arrival time, as when a sprinter waits for the starting pistol? And what happens just after the starting pistol fires? Using functional magnetic resonance imaging ...
Dendritic Spikes and Their Influence on Extracellular Calcium Signaling
(American Physiological Society, 2000)
Extracellular calcium is critical for many neural functions, including neurotransmission, cell adhesion, and neural plasticity. Experiments have shown that normal neural activity is associated with changes in extracellular ...
When Things Are Better or Worse than Expected: The Medial Frontal Cortex and the Allocation of Processing Resources
(MIT, 2006)
Access to limited-capacity neural systems of cognitive control must be restricted to the most relevant information. How the brain identifies and selects items for preferential processing is not fully understood. Anatomical ...
Neural signature of fictive learning signals in a sequential investment task
(NAS, 2007-04-13)
Reinforcement learning models now provide principled guides for a wide range of reward learning experiments in animals and humans. One key learning (error) signal in these models is experiential and reports ongoing temporal ...
Predictability Modulates Human Brain Response to Reward
(Society for Neuroscience, 2001-04-15)
Certain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of ...
Policy Adjustment in a Dynamic Economic Game
(PLOS, 2006-12)
Making sequential decisions to harvest rewards is a notoriously difficult problem. One difficulty is that the real world is not stationary and the reward expected from a contemplated action may depend in complex ways on ...
Molecular mechanisms of experience-dependent plasticity in visual cortex
(Royal Society, 2008)
A remarkable amount of our current knowledge of mechanisms underlying experience-dependent plasticity during cortical development comes from study of the mammalian visual cortex. Recent advances in high-resolution cellular ...
Alexithymic Trait and Voluntary Control in Healthy Adults
(PLOS, 2008-11-12)
Background: Alexithymia is a personality trait characterized by deficiency in understanding, processing, or describing emotions. Recent studies have revealed that alexithymia is associated with less activation of the ...