Search
Now showing items 571-580 of 611
The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target
(Elsevier, 2018-09-19)
Cardiovascular disease remains the single largest cause of natural death in the United States, with a significant cause of mortality associated with cardiac arrhythmias. Presently, options for treating and preventing ...
Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides
(2020-08-11)
Disabled-2 (Dab2) is an adaptor protein that regulates the extent of platelet aggregation by two mechanisms. In the first mechanism, Dab2 intracellularly downregulates the integrin alpha (IIb)beta (3) receptor, converting ...
Physical activity promotion in Latin American populations: a systematic review on issues of internal and external validity
(2014-06-17)
The purpose of this review was to determine the degree to which physical activity interventions for Latin American populations reported on internal and external validity factors using the RE-AIM framework (reach & ...
Assessment of a Continuing Medical Education Intervention Designed to Change Physician Practice Regarding Blood Transfusion
(2020-04-17)
Background and Objectives: Excessive packed red blood cell (pRBC) transfusions are associated with worse clinical outcomes and unnecessary costs. While multi-faceted continuing medical education (CME) approaches have been ...
Pathways and Barriers to Careers in Academic Clinical Cancer Prevention: a Qualitative Study
(2020-11-12)
National surveys document steady declines over time in interest in academic medicine and cancer prevention careers (Am J Prev Med 54(3):444-8, 2018). Through interviews with 16 academic cancer prevention physicians at one ...
Direct Common Carotid Artery Puncture for Endovascular Treatment of Acute Large Vessel Ischemic Stroke in a Patient With Congenital Rare Variant of the Great Vessels
(2020-10-24)
This report describes a case of acute left middle cerebral artery ischemic stroke that occurred in a patient with unique anatomy of the vessels arising from the aortic arch that remained undiagnosed until the age of 36. ...
A clinical series using intensive neurorehabilitation to promote functional motor and cognitive skills in three girls with CASK mutation
(2017-12-19)
Objectives
Children with microcephaly face lifelong psychomotor, cognitive, and communications skills disabilities. Etiology of microcephaly is heterogeneous but presentation often includes seizures, hypotonia, ataxia, ...
Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus
(2019-02-14)
DNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in understanding the maturation ...
Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid
(2020-01-20)
Background
The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in vivo gene ...
Practice facilitation to promote evidence-based screening and management of unhealthy alcohol use in primary care: a practice-level randomized controlled trial
(2020-05-20)
Background
Unhealthy alcohol use is the third leading cause of preventable death in the United States. Evidence demonstrates that screening for unhealthy alcohol use and providing persons engaged in risky drinking with ...