Now showing items 1-10 of 49
Measurement and modeling of transcriptional noise in the cell cycle regulatory network
(Landes Bioscience, 2013-10-01)
Discovering Networks of Perturbed Biological Processes in Hepatocyte Cultures
The liver plays a vital role in glucose homeostasis, the synthesis of bile acids and the detoxification of foreign substances. Liver culture systems are widely used to test adverse effects of drugs and environmental ...
A high-energy-density sugar biobattery based on a synthetic enzymatic pathway
(Springer Nature, 2014-01)
High-energy-density, green, safe batteries are highly desirable for meeting the rapidly growing needs of portable electronics. The incomplete oxidation of sugars mediated by one or a few enzymes in enzymatic fuel cells ...
Summarizing cellular responses as biological process networks
Background Microarray experiments can simultaneously identify thousands of genes that show significant perturbation in expression between two experimental conditions. Response networks, computed through the integration ...
Sensitive Detection of Pathway Perturbations in Cancers
Background The normal functioning of a living cell is characterized by complex interaction networks involving many different types of molecules. Associations detected between diseases and perturbations in well-defined ...
Aerosol microdroplets exhibit a stable pH gradient
Suspended aqueous aerosol droplets (< 50 mu m) are microreactors for many important atmospheric reactions. In droplets and other aquatic environments, pH is arguably the key parameter dictating chemical and biological ...
The hepatocyte proteome in organotypic rat liver models and the influence of the local microenvironment
(Biomed Central Ltd, 2017-06-20)
Background: Liver models that closely mimic the in vivo microenvironment are useful for understanding liver functions, capabilities, and intercellular communication processes. Three-dimensional (3D) liver models assembled ...
Nanoparticulate Nickel-Hosting Phases in Sulfidic Environments: Effects of Ferrous Iron and Bacterial Presence on Mineral Formation Mechanism and Solid-Phase Nickel Distribution
The precipitation of nickel with sulfide is an important process governing the bioavailability of Ni in natural waters, and this process has the potential to effectively remove aqueous Ni contaminants in near-surface ...
XTALKDB: a database of signaling pathway crosstalk
Analysis of signaling pathways and their crosstalk is a cornerstone of systems biology. Thousands of papers have been published on these topics. Surprisingly, there is no database that carefully and explicitly documents ...
3D Hepatic Cultures Simultaneously Maintain Primary Hepatocyte and Liver Sinusoidal Endothelial Cell Phenotypes
Developing in vitro engineered hepatic tissues that exhibit stable phenotype is a major challenge in the field of hepatic tissue engineering. However, the rapid dedifferentiation of hepatic parenchymal (hepatocytes) and ...