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Discovering Networks of Perturbed Biological Processes in Hepatocyte Cultures
(PLOS, 2011-01-05)
The liver plays a vital role in glucose homeostasis, the synthesis of bile acids and the detoxification of foreign substances. Liver culture systems are widely used to test adverse effects of drugs and environmental ...
A high-energy-density sugar biobattery based on a synthetic enzymatic pathway
(Springer Nature, 2014-01)
High-energy-density, green, safe batteries are highly desirable for meeting the rapidly growing needs of portable electronics. The incomplete oxidation of sugars mediated by one or a few enzymes in enzymatic fuel cells ...
Summarizing cellular responses as biological process networks
(2013-07-29)
Background
Microarray experiments can simultaneously identify thousands of genes that show significant perturbation in expression between two experimental conditions. Response networks, computed through the integration ...
Sensitive Detection of Pathway Perturbations in Cancers
(2012-03-21)
Background
The normal functioning of a living cell is characterized by complex interaction networks involving many different types of molecules. Associations detected between diseases and perturbations in well-defined ...
Aerosol microdroplets exhibit a stable pH gradient
(2018-07-10)
Suspended aqueous aerosol droplets (< 50 mu m) are microreactors for many important atmospheric reactions. In droplets and other aquatic environments, pH is arguably the key parameter dictating chemical and biological ...
The hepatocyte proteome in organotypic rat liver models and the influence of the local microenvironment
(Biomed Central Ltd, 2017-06-20)
Background: Liver models that closely mimic the in vivo microenvironment are useful for understanding liver functions, capabilities, and intercellular communication processes. Three-dimensional (3D) liver models assembled ...
Nanoparticulate Nickel-Hosting Phases in Sulfidic Environments: Effects of Ferrous Iron and Bacterial Presence on Mineral Formation Mechanism and Solid-Phase Nickel Distribution
(Frontiers, 2019-06-26)
The precipitation of nickel with sulfide is an important process governing the bioavailability of Ni in natural waters, and this process has the potential to effectively remove aqueous Ni contaminants in near-surface ...
3D Hepatic Cultures Simultaneously Maintain Primary Hepatocyte and Liver Sinusoidal Endothelial Cell Phenotypes
(PLOS, 2010-11-12)
Developing in vitro engineered hepatic tissues that exhibit stable phenotype is a major challenge in the field of hepatic tissue engineering. However, the rapid dedifferentiation of hepatic parenchymal (hepatocytes) and ...
Sequence verification of synthetic DNA by assembly of sequencing reads
(2013-01)
Gene synthesis attempts to assemble user-defined DNA sequences with base-level precision. Verifying the sequences of construction intermediates and the final product of a gene synthesis project is a critical part of the ...
Abiotic synthesis of graphite in hydrothermal vents
(2019-11-15)
Deciphering the origin, age, and composition of deep marine organic carbon remains a challenge in understanding the dynamics of the marine carbon cycle. In particular, the composition of aged organic carbon and what allows ...