Collections in this community

Recent Submissions

  • A Gene-Based Method for Cytogenetic Mapping of Repeat-Rich Mosquito Genomes 

    Masri, Reem A.; Karagodin, Dmitriy A.; Sharma, Atashi; Sharakhova, Maria V. (MDPI, 2021-02-06)
    Long-read sequencing technologies have opened up new avenues of research on the mosquito genome biology, enabling scientists to better understand the remarkable abilities of vectors for transmitting pathogens. Although new ...
  • Trapping conformational states of a flavin-dependent N-monooxygenase in crystallo reveals protein and flavin dynamics 

    Campbell, Ashley C.; Stiers, Kyle M.; Martin Del Campo, Julia S.; Mehra-Chaudhary, Ritcha; Sobrado, Pablo; Tanner, John J. (2020-09-18)
    The siderophore biosynthetic enzyme A (SidA) ornithine hydroxylase fromAspergillus fumigatusis a fungal disease drug target involved in the production of hydroxamate-containing siderophores, which are used by the pathogen ...
  • The Beginning of the End: A Chromosomal Assembly of the New World Malaria Mosquito Ends with a Novel Telomere 

    Compton, Austin; Liang, Jiangtao; Chen, Chujia; Lukyanchikova, Varvara; Qi, Yumin; Potters, Mark; Settlage, Robert; Miller, Dustin; Deschamps, Stephane; Mao, Chunhong; Llaca, Victor; Sharakhov, Igor V.; Tu, Zhijian (Genetics Society of America, 2020-10-01)
    Chromosome level assemblies are accumulating in various taxonomic groups including mosquitoes. However, even in the few reference-quality mosquito assemblies, a significant portion of the heterochromatic regions including ...
  • Nix is a male-determining factor in the Asian tiger mosquito Aedes albopictus 

    Liu, Peiwen; Jin, Binbin; Li, Xiaocong; Zhao, Yijie; Gu, Jinbao; Biedler, James K.; Tu, Zhijian Jake; Chen, Xiao-Guang (2020-03)
    The initial signal that governs sex determination is highly variable among insects. A homolog of Nix, the male-determining factor in Aedes aegypti, was previously found in the Asian tiger mosquito Ae. albopictus. Here we ...
  • Molecular action of pyriproxyfen: Role of the Methoprene-tolerant protein in the pyriproxyfen-induced sterilization of adult female mosquitoes 

    Ahmed, Tahmina Hossain; Saunders, T. Randolph; Mullins, Donald; Rahman, Mohammad Zillur; Zhu, Jinsong (2020-08)
    Exposure of adult mosquitoes to pyriproxyfen (PPF), an analog of insect juvenile hormone (JH), has shown promise to effectively sterilize female mosquitoes. However, the underlying mechanisms of the PPF-induced decrease ...
  • Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides 

    Song, Wei; Gottschalk, Carter J.; Tang, Tuo-Xian; Biscardi, Andrew; Ellena, Jeffrey F.; Finkielstein, Carla, V; Brown, Anne M.; Capelluto, Daniel G. S. (2020-08-11)
    Disabled-2 (Dab2) is an adaptor protein that regulates the extent of platelet aggregation by two mechanisms. In the first mechanism, Dab2 intracellularly downregulates the integrin alpha (IIb)beta (3) receptor, converting ...
  • Broad spectrum immunomodulatory effects of Anopheles gambiae microRNAs and their use for transgenic suppression of Plasmodium 

    Dong, Shengzhang; Fu, Xiaonan; Dong, Yuemei; Simoes, Maria L.; Zhu, Jinsong; Dimopoulos, George (2020-04)
    Malaria, caused by the protozoan parasite Plasmodium and transmitted by Anopheles mosquitoes, represents a major threat to human health. Plasmodium's infection cycle in the Anopheles vector is critical for transmission of ...
  • Dynamic miRNA-mRNA interactions coordinate gene expression in adult Anopheles gambiae 

    Fu, Xiaonan; Liu, Pengcheng; Dimopoulos, George; Zhu, Jinsong (2020-04)
    microRNAs (miRNAs) are increasingly recognized as important regulators of many biological processes in mosquitoes, vectors of numerous devastating infectious diseases. Identification of bona fide targets remains the ...
  • Characterization of a female germline and early zygote promoter from the transcription factor bZip1 in the dengue mosquito Aedes aegypti 

    Kojin, Bianca B.; Biedler, James K.; Tu, Zhijian; Adelman, Zach N. (2020-07-17)
    Background The wide distribution of Aedes aegypti, the main vector of dengue and yellow fever viruses, currently puts three billion people in the world at risk of infection with these viruses. Continuous transmission of ...
  • Nix alone is sufficient to convert female Aedes aegypti into fertile males and myo-sex is needed for male flight 

    Aryan, Azadeh; Anderson, Michelle A.E.; Biedler, James K.; Qi, Yumin; Overcash, Justin M.; Naumenko, Anastasia N.; Sharakhova, Maria V.; Mao, Chunhong; Adelman, Zach N.; Tu, Zhijian (NAS, 2020-06-12)
    A dominant male-determining locus (M-locus) establishes the male sex (M/m) in the yellow fever mosquito, Aedes aegypti. Nix, a gene in the M-locus, was shown to be a male-determining factor (M factor) as somatic knockout ...
  • Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants? 

    Cridland, Caitlin; Gillaspy, Glenda E. (MDPI, 2020-06-17)
    The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the ...
  • Engel Hall News, Fall 2019 

    Unknown author (Virginia Tech. Biochemistry Department, 2019)
    This newsletter highlights events, new faculty, and student research in the Department of Biochemistry at Virginia Tech.
  • Large Variability of Iodine Content in Retail Cow’s Milk in the U.S. 

    Roseland, Janet M.; Phillips, Katherine M.; Patterson, Kristine Y.; Pehrsson, Pamela R.; Bahadur, Rahul; Ershow, Abby G.; Somanchi, Meena (MDPI, 2020-04-28)
    Iodine intake is of contemporary public health interest. The recommended daily iodine intake is 150 µg for most adults, and milk is an important source of iodine in the U.S. diet. Iodine concentration in cow’s ...
  • Interlaboratory Trial for Measurement of Vitamin D and 25-Hydroxyvitamin D [25(OH)D] in Foods and a Dietary Supplement Using Liquid Chromatography-Mass Spectrometry 

    Roseland, Janet Maxwell; Patterson, Kristine Y.; Andrews, Karen W.; Phillips, Katherine M.; Phillips, Melissa M.; Pehrsson, Pamela R.; Dufresne, Guy L.; Jakobsen, Jette; Gusev, Pavel A.; Savarala, Sushma; Nguyen, Quynhanh V.; Makowski, Andrew J.; Scheuerell, Chad R.; Larouche, Guillaume P.; Wise, Stephen A.; Harnly, James M.; Williams, Juhi R.; Betz, Joseph M.; Taylor, Christine L. (2016-04-27)
    Assessment of total vitamin D intake from foods and dietary supplements (DSs) may be incomplete if 25-hydroxyvitamin D [25(OH)D] intake is not included. However, 25(OH)D data for such intake assessments are lacking, no ...
  • Exploring Rain as Source of Biological Control Agents for Fire Blight on Apple 

    Llontop, Marco E. Mechan; Hurley, Kelly; Tian, Long; Galeano, Vivian A. Bernal; Wildschutte, Hans K.; Marine, Sasha C.; Yoder, Keith S.; Vinatzer, Boris A. (2020-02-14)
    Poor survival on plants can limit the efficacy of Biological Control Agents (BCAs) in the field. Yet bacteria survive in the atmosphere, despite their exposure to high solar radiation and extreme temperatures. If conditions ...
  • Brown marmorated stink bug, Halyomorpha halys (Stål), genome: putative underpinnings of polyphagy, insecticide resistance potential and biology of a top worldwide pest 

    Sparks, Michael E.; Bansal, Raman; Benoit, Joshua B.; Blackburn, Michael B.; Chao, Hsu; Chen, Mengyao; Cheng, Sammy; Childers, Christopher; Dinh, Huyen; Doddapaneni, Harsha V.; Dugan, Shannon; Elpidina, Elena N.; Farrow, David W.; Friedrich, Markus; Gibbs, Richard A.; Hall, Brantley; Han, Yi; Hardy, Richard W.; Holmes, Christopher J.; Hughes, Daniel S. T.; Ioannidis, Panagiotis; Cheatle Jarvela, Alys M.; Johnston, J. S.; Jones, Jeffery W.; Kronmiller, Brent A.; Kung, Faith; Lee, Sandra L.; Martynov, Alexander G.; Masterson, Patrick; Maumus, Florian; Munoz-Torres, Monica; Murali, Shwetha C.; Murphy, Terence D.; Muzny, Donna M.; Nelson, David R.; Oppert, Brenda; Panfilio, Kristen A.; Paula, Débora P.; Pick, Leslie; Poelchau, Monica F.; Qu, Jiaxin; Reding, Katie; Rhoades, Joshua H.; Rhodes, Adelaide; Richards, Stephen; Richter, Rose; Robertson, Hugh M.; Rosendale, Andrew J.; Tu, Zhijian J.; Velamuri, Arun S.; Waterhouse, Robert M.; Weirauch, Matthew T.; Wells, Jackson T.; Werren, John H.; Worley, Kim C.; Zdobnov, Evgeny M.; Gundersen-Rindal, Dawn E. (2020-03-14)
    Background Halyomorpha halys (Stål), the brown marmorated stink bug, is a highly invasive insect species due in part to its exceptionally high levels of polyphagy. This species is also a nuisance due to overwintering in ...
  • Survey of vitamin D and 25-hydroxyvitamin D in traditional native Alaskan meats, fish, and oils 

    Phillips, Katherine M.; Pehrsson, Pamela R.; Patterson, Kristine Y. (2018-12)
    Greater consumption of traditional foods has been associated with improved vitamin D status in Arctic and sub Arctic populations, including Alaskan Native Americans. However, lack of vitamin D food composition data impairs ...
  • Cooking parameters affect the sodium content of prepared pasta 

    Bianchi, Laurie M.; Phillips, Katherine M.; McGinty, Ryan C.; Ahuja, Jaspreet K.; Pehrsson, Pamela R. (2019-01-15)
    The quantitative effect of different preparation variables on the sodium content of cooked dry pasta was evaluated. Semolina spaghetti (< 5 mg sodium/100 g) was cooked by a typical method (454 g, 5.68 L water, 36 g salt, ...
  • Implications of two different methods for analyzing total dietary fiber in foods for food composition databases 

    Phillips, Katherine M.; Haytowitz, David B.; Pehrsson, Pamela R. (2019-12)
    Since 1989, total dietary fiber values in USDA databases were determined by the enzymatic-gravimetric (EGF) method (AOAC 991.43), where "fiber" is the residue remaining after samples are subjected to enzymatic treatments ...
  • The olfactory basis of orchid pollination by mosquitoes 

    Lahondère, Chloé; Vinauger, Clément; Okubo, Ryo P.; Wolff, Gabriella H.; Chan, Jeremy K.; Akbari, Omar S.; Riffell, Jeffrey A. (National Academy of Sciences, 2020-01-07)
    Mosquitoes are important vectors of disease and require sources of carbohydrates for reproduction and survival. Unlike host-related behaviors of mosquitoes, comparatively less is understood about the mechanisms involved ...

View more