Scholarly Works, Department of Biomedical Engineering and Mechanics
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Research articles, presentations, and other scholarship
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MRI brain templates of the male Yucatan minipig
(Elsevier, 2021-07-15)The pig is growing in popularity as an experimental animal because its gyrencephalic brain is similar to humans. Currently, however, there is a lack of appropriate brain templates to support functional and structural ... -
Wind Dispersal of Natural and Biomimetic Maple Samaras
(MDPI, 2021-03-29)Maple trees (genus Acer) accomplish the task of distributing objects to a wide area by producing seeds, known as samaras, which are carried by the wind as they autorotate and slowly descend to the ground. With the ... -
Numerical techniques to find optimal input parameters for achieving mean particles’ temperature and axial velocity in atmospheric plasma spray process
(Nature Research, 2020)We numerically find values of four process input parameters, namely, the argon flow rate, the hydrogen flow rate, the powder feed rate, and the current, that yield the desired mean particles’ temperature and the mean ... -
Utilizing Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Analyze Interstitial Fluid Flow and Transport in Glioblastoma and the Surrounding Parenchyma in Human Patients
(MDPI, 2021-02-04)Background: Glioblastoma (GBM) is the deadliest and most common brain tumor in adults, with poor survival and response to aggressive therapy. Limited access of drugs to tumor cells is one reason for such grim clinical ... -
Effects of coral colony morphology on turbulent flow dynamics
(2020-10-07)Local flow dynamics play a central role in physiological processes like respiration and nutrient uptake in coral reefs. Despite the importance of corals as hosts to a quarter of all marine life, and the pervasive threats ... -
Elevated perfusate [Na+] increases contractile dysfunction during ischemia and reperfusion
(2020-10-14)Recent studies revealed that relatively small changes in perfusate sodium ([Na+](o)) composition significantly affect cardiac electrical conduction and stability in contraction arrested ex vivo Langendorff heart preparations ... -
Dynamics of Cell Death After Conventional IRE and H-FIRE Treatments
(2020-02-05)High-frequency irreversible electroporation (H-FIRE) has emerged as an alternative to conventional irreversible electroporation (IRE) to overcome the issues associated with neuromuscular electrical stimulation that appear ... -
High-Frequency Irreversible Electroporation for Treatment of Primary Liver Cancer: A Proof-of-Principle Study in Canine Hepatocellular Carcinoma
(2020-03)Purpose: To determine the safety and feasibility of percutaneous high-frequency irreversible electroporation (HFIRE) for primary liver cancer and evaluate the HFIRE-induced local immune response. Materials and Methods: ... -
MRI analysis to map interstitial flow in the brain tumor microenvironment
(AIP Publishing, 2018-06-26)Glioblastoma (GBM), a highly aggressive form of brain tumor, is a disease marked by extensive invasion into the surrounding brain. Interstitial fluid flow (IFF), or the movement of fluid within the spaces between cells, ... -
Cerium Oxide Nanoparticles Improve Outcome after In Vitro and In Vivo Mild Traumatic Brain Injury
(2020-06-15)Mild traumatic brain injury results in aberrant free radical generation, which is associated with oxidative stress, secondary injury signaling cascades, mitochondrial dysfunction, and poor functional outcome. Pharmacological ... -
Deactivation of Ascaris suum eggs using electroporation and sequential inactivation with chemical disinfection
(2020-09)Electroporation has been evaluated as a potential backend wastewater treatment for deactivation ofAscaris suumeggs in buffer solution. Initial results indicate that eggshell permeability is affected by the pulse train ... -
Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation
(MDPI, 2020-12-10)Barrier function is a vital homeostatic mechanism employed by epithelial and endothelial tissue. Diseases across a wide range of tissue types involve dynamic changes in transcellular junctional complexes and the actin ... -
Modeling iontophoretic drug delivery in a microfluidic device
(2020-09-21)Iontophoresis employs low-intensity electrical voltage and continuous constant current to direct a charged drug into a tissue. Iontophoretic drug delivery has recently been used as a novel method for cancer treatment in ... -
Focused ultrasound extraction (FUSE) for the rapid extraction of DNA from tissue matrices
(2020-10-09)Rapid DNA extraction is a critical barrier for routine and fieldable genetics tests for applications in conservation, such as illegal trafficking and fraudulent mislabelling. Here, we develop a non-thermal focused ultrasound ... -
Glial Activation in the Thalamus Contributes to Vestibulomotor Deficits Following Blast-Induced Neurotrauma
(2020-07-15)Vestibular impairment has become a frequent consequence following blast-related traumatic brain injury (bTBI) in military personnel and Veterans. Behavioral outcomes such as depression, fear and anxiety are also common ... -
The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats
(2020-07-17)Allen and Pennington et al. show that the cardiolipin-binding peptide elamipretide mitigates disease-induced fragmentation of cristae networks following cardiac ischemia reperfusion in rats. This study suggests that ... -
Microfluidics for genome-wide studies involving next generation sequencing
(AIP Publishing, 2017-03-10)Next-generation sequencing (NGS) has revolutionized how molecular biology studies are conducted. Its decreasing cost and increasing throughput permit profiling of genomic, transcriptomic, and epigenomic features for a wide ... -
A Sustainable Engineering Solution for Paediatric Dehydration in Low-Resource Clinical Environments
(Engineers Without Borders Australia, 2016)Engineering efforts in low resource environments pose a unique set of challenges, requiring an in-depth understanding of local needs, comprehensive mapping of community resources, and extensive collaboration with local ... -
Cumulative Effects of Prior Concussion and Primary Sport Participation on Brain Morphometry in Collegiate Athletes: A Study From the NCAA-DoD CARE Consortium
(2020-07-28)Prior studies have reported long-term differences in brain structure (brain morphometry) as being associated with cumulative concussion and contact sport participation. There is emerging evidence to suggest that similar ... -
Starting a Fire Without Flame: The Induction of Cell Death and Inflammation in Electroporation-Based Tumor Ablation Strategies
(2020-07-28)New therapeutic strategies and paradigms are direly needed for the treatment of cancer. While the surgical removal of tumors is favored in most cancer treatment plans, resection options are often limited based on tumor ...
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