Now showing items 1-2 of 2

    • Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle 

      Silva, Kleiton Augusto Santos; Ghiarone, Thaysa; Grant, DeAna; White, Tommi; Frisard, Madlyn I.; Chandrasekar, Bysani; Delafontaine, Patrice; Yoshida, Tadashi; Schreiber, Kathy; Sukhanov, Sergiy (2019-06-01)
      Angiotensin II (ANG II)-induced skeletal muscle wasting is characterized by activation of the ubiquitin-proteasome system. However, the potential involvement of proteolytic system macroautophagy/autophagy in this wasting ...
    • Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance 

      Azzimato, Valerio; Jager, Jennifer; Chen, Ping; Morgantini, Cecilia; Levi, Laura; Barreby, Emelie; Sulen, Andre; Oses, Carolina; Willerbrords, Joost; Xu, Connie; Li, Xidan; Shen, Joanne X.; Akbar, Naveed; Haag, Lars; Ellis, Ewa; Wålhen, Kerstin; Näslund, Erik; Thorell, Anders; Choudhury, Robin P.; Lauschke, Volker M.; Rydén, Mikael; Craige, Siobhan M.; Aouadi, Myriam (2020-02-26)
      Obesity and insulin resistance are risk factors for nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease worldwide. Because no approved medication nor an accurate and noninvasive diagnosis is ...