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Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays

Scaria, Joy; Chen, Jenn-Wei; Useh, Nicodemus; He, Hongxuan; McDonough, Sean P.; Mao, Chunhong; Sobral, Bruno; Chang, Yung-Fu (International Society for Infectious Diseases, 2014-10)

Objectives: Clostridium difficile infection (CDI) is the leading cause of infectious diarrhea in North America and Europe. The risk of CDI increases significantly in the case where antimicrobial treatment reduces the number ...

Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types

Guo, Shaogui; Zheng, Yi; Joung, Je-Gun; Liu, Shiqiang; Zhang, Zhonghua; Crasta, Oswald R.; Sobral, Bruno; Xu, Yong; Huang, Sanwen; Fei, Zhangjun (2010-06-17)

Background Cucumber, Cucumis sativus L., is an economically and nutritionally important crop of the Cucurbitaceae family and has long served as a primary model system for sex determination studies. Recently, the sequencing ...

The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pesti

Dye, Matthew D.; Neff, Chris; Dufford, Max; Rivera, Corban G.; Shattuck, Donna; Bassaganya-Riera, Josep; Murali, T. M.; Sobral, Bruno (Public Library of Science, 2010-08-09)

Background: Bacillus anthracis, Francisella tularensis, and Yersinia pestis are bacterial pathogens that can cause anthrax, lethal acute pneumonic disease, and bubonic plague, respectively, and are listed as NIAID Category ...

An emerging cyberinfrastructure for biodefense pathogen and pathogen-host data

Zhang, C.; Crasta, O.; Cammer, S.; Will, R.; Kenyon, R.; Sullivan, D.; Yu, Q.; Sun, W.; Jha, R.; Liu, D.; Xue, T.; Zhang, Y.; Moore, M.; McGarvey, P.; Huang, H.; Chen, Y.; Zhang, J.; Mazumder, R.; Wu, C.; Sobral, Bruno (2008-01)

The NIAID-funded Biodefense Proteomics Resource Center (RC) provides storage, dissemination, visualization and analysis capabilities for the experimental data deposited by seven Proteomics Research Centers (PRCs). The data ...

Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection

Mohapatra, Saroj K.; Cole, Leah E.; Evans, Clive; Sobral, Bruno; Bassaganya-Riera, Josep; Hontecillas, Raquel; Vogel, Stefanie N.; Crasta, Oswald R. (2010-01-18)

Background It has been shown previously that administration of Francisella tularensis (Ft) Live Vaccine Strain (LVS) lipopolysaccharide (LPS) protects mice against subsequent challenge with Ft LVS and blunts the ...

Systems Integration of Biodefense Omics Data for Analysis of Pathogen-Host Interactions and Identification of Potential Targets

McGarvey, Peter B.; Huang, Hongzhan; Mazumder, Raja; Zhang, Jian; Chen, Yongxing; Zhang, Chengdong; Cammer, Stephen; Will, Rebecca; Odle, Margie; Sobral, Bruno; Moore, Margaret; Wu, Cathy H. (Public Library of Science, 2009-09-25)

The NIAID (National Institute for Allergy and Infectious Diseases) Biodefense Proteomics program aims to identify targets for potential vaccines, therapeutics, and diagnostics for agents of concern in bioterrorism, including ...

Louse- and flea-borne rickettsioses: biological and genomic analyses

Gillespie, J. J.; Ammerman, Nicole C.; Beier-Sexton, M.; Sobral, Bruno; Azad, Abdu F. (EDP SCIENCES, 2009-03)

In contrast to 15 or more validated and/or proposed tick-borne spotted fever group species, only three named medically important rickettsial species are associated with insects. These insect-borne rickettsiae are comprised ...

PATRIC: The VBI PathoSystems Resource Integration Center

Snyder, E. E.; Kampanya, N.; Lu, J.; Nordberg, E. K.; Karur, H. R.; Shukla, M.; Soneja, J.; Tian, Y.; Xue, T.; Yoo, H.; Zhang, F.; Dharmanolla, C.; Dongre, N. V.; Gillespie, J. J.; Hamelius, J.; Hance, M.; Huntington, K. I.; Jukneliene, D.; Koziski, J.; Mackasmiel, L.; Mane, S. P.; Nguyen, V.; Purkayastha, A.; Shallom, J.; Yu, G.; Guo, Y.; Gabbard, Joseph L.; Hix, D.; Azad, A. F.; Baker, S. C.; Boyle, S. M.; Khudyakov, Y.; Meng, Xiang-Jin; Rupprecht, C.; Vinje, J.; Crasta, O. R.; Czar, M. J.; Dickerman, A.; Eckart, J. D.; Kenyon, R.; Will, R.; Setubal, J. C.; Sobral, Bruno (2007-01)

The PathoSystems Resource Integration Center (PATRIC) is one of eight Bioinformatics Resource Centers (BRCs) funded by the National Institute of Allergy and Infection Diseases (NIAID) to create a data and analysis resource ...

Plasmids and Rickettsial Evolution: Insight from Rickettsia felis

Gillespie, Joseph J.; Beier, Magda S.; Rahman, M. Sayeedur; Ammerman, Nicole C.; Shallom, Joshua M.; Purkayastha, Anjan; Sobral, Bruno; Azad, Abdu F. (PLOS, 2007-03-07)

Background The genome sequence of Rickettsia felis revealed a number of rickettsial genetic anomalies that likely contribute not only to a large genome size relative to other rickettsiae, but also to phenotypic oddities ...

The Condition-Dependent Transcriptional Landscape of Burkholderia pseudomallei

Ooi, Wen Fong; Ong, Catherine; Nandi, Tannistga; Kreisberg, Jason F.; Chua, Hui Hoon; Sun, Guangwen; Chen, Yahua; Mueller, Claudia; Conejero, Laura; Eshaghi, Majid; Ang, Roy Moh Lik; Liu, Jianhua; Sobral, Bruno; Korbsrisate, Sunee; Gen, Yunn Hwen; Titball, Richard W.; Bancroft, Gregory J.; Valade, Eric; Tan, Patrick (Public Library of Science, 2013-09-12)

Burkholderia pseudomallei (Bp), the causative agent of the often-deadly infectious disease melioidosis, contains one of the largest prokaryotic genomes sequenced to date, at 7.2 Mb with two large circular chromosomes (1 ...