Now showing items 1-10 of 97
A syntactic model to design and verify synthetic genetic constructs derived from standard biological parts
Motivation: The sequence of artificial genetic constructs is composed of multiple functional fragments, or genetic parts, involved in different molecular steps of gene expression mechanisms. Biologists have deciphered ...
Enzymatic, immunological and phylogenetic characterization of Brucella suis urease
Background The sequenced genomes of the Brucella spp. have two urease operons, ure-1 and ure-2, but there is evidence that only one is responsible for encoding an active urease. The present work describes the purification ...
Inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active anti proliferative and tumor cell differentiation agent
(American Society of Parasitology, 2009-02)
We searched the National Cancer Institute (NCI) compound library for structures related to the antitumor quinoline NSC3852 (5-nitroso-8-quinolinol) and used a computer algorithm to predict the antiprotozoan activity for ...
Scientific Annual Report 2008
(Virginia Bioinformatics Institute, 2008-07-22)
Virginia Bioinformatics Institute 2003 Annual Report
(Virginia Bioinformatics Institute, 2004-01-18)
Global Demethylation of Rat Chondrosarcoma Cells after Treatment with 5-Aza-2′-Deoxycytidine Results in Increased Tumorigenicity
(Public Library of Science, 2009-12-17)
Abnormal patterns of DNA methylation are observed in several types of human cancer. While localized DNA methylation of CpG islands has been associated with gene silencing, the effect that genome-wide loss of methylation ...
An Atlas of the Speed of Copy Number Changes in Animal Gene Families and Its Implications
The notion that gene duplications generating new genes and functions is commonly accepted in evolutionary biology. However, this assumption is more speculative from theory rather than well proven in genome-wide studies. ...
Virginia Bioinformatics Institute 2004 Annual Report
(Virginia Bioinformatics Institute, 2005-01-17)
Targeted Development of Registries of Biological Parts
(Public Library of Science, 2008-07-16)
The design and construction of novel biological systems by combining basic building blocks represents a dominant paradigm in synthetic biology. Creating and maintaining a database of these building blocks is a way to ...
Deja vu: a database of highly similar citations in the scientific literature
(Oxford University Press, 2008-08-09)
In the scientific research community, plagiarism and covert multiple publications of the same data are considered unacceptable because they undermine the public confidence in the scientific integrity. Yet, little has been ...