Now showing items 1-10 of 560
A syntactic model to design and verify synthetic genetic constructs derived from standard biological parts
Motivation: The sequence of artificial genetic constructs is composed of multiple functional fragments, or genetic parts, involved in different molecular steps of gene expression mechanisms. Biologists have deciphered ...
Enzymatic, immunological and phylogenetic characterization of Brucella suis urease
Background The sequenced genomes of the Brucella spp. have two urease operons, ure-1 and ure-2, but there is evidence that only one is responsible for encoding an active urease. The present work describes the purification ...
Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma
(Springer Nature, 2018-01-19)
Glioma is a unique neoplastic disease that develops exclusively in the central nervous system (CNS) and rarely metastasizes to other tissues. This feature strongly implicates the tumor-host CNS microenvironment in gliomagenesis ...
Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel
Biodiversity refugia formed by unique features of the Mediterranean arid landscape, such as the dramatic ecological contrast of "Evolution Canyon," provide a natural laboratory in which local adaptations to divergent ...
Preventive and Prophylactic Mechanisms of Action of Pomegranate Bioactive Constituents
Pomegranate fruit presents strong anti-inflammatory, antioxidant, antiobesity, and antitumoral properties, thus leading to an increased popularity as a functional food and nutraceutical source since ancient times. It can ...
Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates
(Springer Nature, 2017-11-17)
Determining the mechanisms by which a species adapts to its environment is a key endeavor in the study of evolution. In particular, relatively little is known about how transcriptional processes are fine-tuned to adjust ...
Inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active anti proliferative and tumor cell differentiation agent
(American Society of Parasitology, 2009-02)
We searched the National Cancer Institute (NCI) compound library for structures related to the antitumor quinoline NSC3852 (5-nitroso-8-quinolinol) and used a computer algorithm to predict the antiprotozoan activity for ...
Origin, Evolution, and Genotyping of Emergent Porcine Epidemic Diarrhea Virus Strains in the United States
(American Society for Microbiology, 2013-09)
Coronaviruses are known to infect humans and other animals and cause respiratory and gastrointestinal diseases. Here we report the emergence of porcine epidemic diarrhea virus (PEDV) in the United States and determination ...
Scientific Annual Report 2008
(Virginia Bioinformatics Institute, 2008-07-22)
Insight of Genus Corynebacterium: Ascertaining the Role of Pathogenic and Non-pathogenic Species
This review gathers recent information about genomic and transcriptomic studies in the Corynebacterium genus, exploring, for example, prediction of pathogenicity islands and stress response in different pathogenic and ...