Now showing items 1-20 of 580

    • Research Needs, Challenges, and Strategic Approaches for Natural Hazards and Disaster Reconnaissance 

      Wartman, Joseph; Berman, Jeffrey W.; Bostrom, Ann; Miles, Scott; Olsen, Michael; Gurley, Kurtis; Irish, Jennifer L.; Lowes, Laura; Tanner, Troy; Dafni, Jake; Grilliot, Michael; Lyda, Andrew; Peltier, Jaqueline (2020-11-10)
      Natural hazards and disaster reconnaissance investigations have provided many lessons for the research and practice communities and have greatly improved our scientific understanding of extreme events. Yet, many challenges ...
    • Nix is a male-determining factor in the Asian tiger mosquito Aedes albopictus 

      Liu, Peiwen; Jin, Binbin; Li, Xiaocong; Zhao, Yijie; Gu, Jinbao; Biedler, James K.; Tu, Zhijian Jake; Chen, Xiao-Guang (2020-03)
      The initial signal that governs sex determination is highly variable among insects. A homolog of Nix, the male-determining factor in Aedes aegypti, was previously found in the Asian tiger mosquito Ae. albopictus. Here we ...
    • Safety of drug use in patients with a primary mitochondrial disease: An international Delphi-based consensus 

      De Vries, Maaike C.; Brown, David A.; Allen, Mitchell E.; Bindoff, Laurence; Gorman, Grainne S.; Karaa, Amel; Keshavan, Nandaki; Lamperti, Costanza; McFarland, Robert; Ng, Yi Shiau; O'Callaghan, Mar; Pitceathly, Robert D. S.; Rahman, Shamima; Russel, Frans G. M.; Varhaug, Kristin N.; Schirris, Tom J. J.; Mancuso, Michelangelo (2020-07)
      Clinical guidance is often sought when prescribing drugs for patients with primary mitochondrial disease. Theoretical considerations concerning drug safety in patients with mitochondrial disease may lead to unnecessary ...
    • Early Holocene Greenland-ice mass loss likely triggered earthquakes and tsunami 

      Steffen, Rebekka; Steffen, Holger; Weiss, Robert; Lecavalier, Benoit S.; Milne, Glenn A.; Woodroffe, Sarah A.; Bennike, Ole (2020-09-15)
      Due to their large mass, ice sheets induce significant stresses in the Earth's crust. Stress release during deglaciation can trigger large-magnitude earthquakes, as indicated by surface faults in northern Europe. Although ...
    • Nutritional protective mechanisms against gut inflammation 

      Viladomiu, Monica; Hontecillas, Raquel; Yuan, Lijuan; Lu, Pinyi; Bassaganya-Riera, Josep (Elsevier, 2013-01-15)
      Inflammatory bowel disease (IBD) is a debilitating and widespread immune-mediated illness characterized by excessive inflammatory and effector mucosal responses leading to tissue destruction at the gastrointestinal tract. ...
    • A survey of quality of life indicators in the Romanian Roma population following the ‘Decade of Roma Inclusion’ 

      Doherty, Rebecca Powell; Telionis, Pyrros A.; Müller-Demary, Daniel; Hosszu, Alexandra; Duminica, Ana; Bertke, Andrea; Lewis, Bryan L.; Eubank, Stephen (F1000Research, 2019-09-18)
      Background: This study explores how the Roma in Romania, the EU’s most concentrated population, are faring in terms of a number of quality of life indicators, including poverty levels, healthcare, education, water, sanitation, ...
    • The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats 

      Allen, Mitchell E.; Pennington, Edward Ross; Perry, Justin B.; Dadoo, Sahil; Makrecka-Kuka, Marina; Dambrova, Maija; Moukdar, Fatiha; Patel, Hetal D.; Han, Xianlin; Kidd, Grahame K.; Benson, Emily K.; Raisch, Tristan B.; Poelzing, Steven; Brown, David A.; Shaikh, Saame Raza (2020-07-17)
      Allen and Pennington et al. show that the cardiolipin-binding peptide elamipretide mitigates disease-induced fragmentation of cristae networks following cardiac ischemia reperfusion in rats. This study suggests that ...
    • Using artificial intelligence for improving stroke diagnosis in emergency departments: a practical framework 

      Abedi, Vida; Khan, Ayesha; Chaudhary, Durgesh; Misra, Debdipto; Avula, Venkatesh; Mathrawala, Dhruv; Kraus, Chadd; Marshall, Kyle A.; Chaudhary, Nayan; Li, Xiao; Schirmer, Clemens M.; Scalzo, Fabien; Li, Jiang; Zand, Ramin (2020-08)
      Stroke is the fifth leading cause of death in the United States and a major cause of severe disability worldwide. Yet, recognizing the signs of stroke in an acute setting is still challenging and leads to loss of opportunity ...
    • Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides 

      Song, Wei; Gottschalk, Carter J.; Tang, Tuo-Xian; Biscardi, Andrew; Ellena, Jeffrey F.; Finkielstein, Carla, V; Brown, Anne M.; Capelluto, Daniel G. S. (2020-08-11)
      Disabled-2 (Dab2) is an adaptor protein that regulates the extent of platelet aggregation by two mechanisms. In the first mechanism, Dab2 intracellularly downregulates the integrin alpha (IIb)beta (3) receptor, converting ...
    • Inactivation of Aeromonas hydrophila and Vibrio parahaemolyticus by Curcumin-Mediated Photosensitization and Nanobubble-Ultrasonication Approaches 

      Rafeeq, Shamil; Shiroodi, Setareh; Schwarz, Michael H.; Nitin, Nitin; Ovissipour, Mahmoudreza (MDPI, 2020-09-16)
      The antimicrobial efficacy of novel photodynamic inactivation and nanobubble technologies was evaluated against Vibrio parahaemolyticus and Aeromonas hydrophila as two important aquatic microbial pathogens. ...
    • Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression 

      Yao, Xiangyu; Kojima, Shihoko; Chen, Jing (2020-04)
      The mammalian circadian clock is deeply rooted in rhythmic regulation of gene expression. Rhythmic transcriptional control mediated by the circadian transcription factors is thought to be the main driver of mammalian ...
    • Associations between peer attachment and neural correlates of risk processing across adolescence 

      Asscheman, J. Susanne; Deater-Deckard, Kirby; Lauharatanahirun, Nina; van Lier, Pol A. C.; Koot, Susanne; King-Casas, Brooks; Kim-Spoon, Jungmeen (2020-04)
      Adolescence is a period of increased risk-taking behavior where individual differences in risk taking may relate to both adverse and positive experiences with peers. Yet, knowledge on how risk processing develops in the ...
    • Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke 

      Cao, Rui; Li, Jun; Kharel, Yugesh; Zhang, Chenchu; Morris, Emily; Santos, Webster L.; Lynch, Kevin R.; Zuo, Zhiyi; Hu, Song (IvySpring, 2018-11-29)
      Rationale: Emerging evidence has suggested that sphingosine 1-phosphate (S1P), a bioactive metabolite of sphingolipids, may play an important role in the pathophysiological processes of cerebral hypoxia and ischemia. ...
    • Mechanism of sphingosine 1-phosphate clearance from blood 

      Kharel, Yugesh; Huang, Tao; Salamon, Anita; Harris, Thurl E.; Santos, Webster L.; Lynch, Kevin R. (Portland Press, 2020-03-06)
      The interplay of sphingosine 1-phosphate (S1P) synthetic and degradative enzymes as well as S1P exporters creates concentration gradients that are a fundamental to S1P biology. Extracellular S1P levels, such as in blood ...
    • Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane 

      Kenwood, Brandon M.; Weaver, Janelle L.; Bajwa, Amandeep; Poon, Ivan K.; Byrne, Frances L.; Murrow, Beverley A.; Calderone, Joseph A.; Huang, Liping; Divakaruni, Ajit S.; Tomsig, Jose L.; Okabe, Kohki; Lo, Ryan H.; Coleman, G. Cameron; Columbus, Linda; Yan, Zhen; Saucerman, Jeffrey J.; Smith, Jeffrey S.; Holmes, Jeffrey W.; Lynch, Kevin R.; Ravichandran, Kodi S.; Uchiyama, Seiichi; Santos, Webster L.; Rogers, George W.; Okusa, Mark D.; Bayliss, Douglas A.; Hoehn, Kyle L. (Elsevier, 2013)
      Dysregulation of oxidative phosphorylation is associated with increased mitochondrial reactive oxygen species production and some of the most prevalent human diseases including obesity, cancer, diabetes, neurodegeneration, ...
    • Improved reference genome of the arboviral vector Aedes albopictus 

      Palatini, Umberto; Masri, Reem A.; Cosme, Luciano V.; Koren, Sergey; Thibaud-Nissen, Françoise; Biedler, James K.; Krsticevic, Flavia; Johnston, J. S.; Halbach, Rebecca; Crawford, Jacob E.; Antoshechkin, Igor; Failloux, Anna-Bella; Pischedda, Elisa; Marconcini, Michele; Ghurye, Jay; Rhie, Arang; Sharma, Atashi; Karagodin, Dmitry A.; Jenrette, Jeremy; Gamez, Stephanie; Miesen, Pascal; Masterson, Patrick; Caccone, Adalgisa; Sharakhova, Maria V.; Tu, Zhijian; Papathanos, Philippos A.; Van Rij, Ronald P.; Akbari, Omar S.; Powell, Jeffrey R.; Phillippy, Adam M.; Bonizzoni, Mariangela (2020-08-26)
      Background The Asian tiger mosquito Aedes albopictus is globally expanding and has become the main vector for human arboviruses in Europe. With limited antiviral drugs and vaccines available, vector control is the primary ...
    • Genomic differentiation and intercontinental population structure of mosquito vectors Culex pipiens pipiens and Culex pipiens molestus 

      Yurchenko, Andrey A.; Masri, Reem A.; Khrabrova, Natalia, V.; Sibataev, Anuarbek K.; Fritz, Megan L.; Sharakhova, Maria, V. (2020-05-05)
      Understanding the population structure and mechanisms of taxa diversification is important for organisms responsible for the transmission of human diseases. Two vectors of West Nile virus, Culex pipiens pipiens and Cx. p. ...
    • Global Distribution and Evolution of Mycobacterium bovis Lineages 

      Zimpel, Cristina Kraemer; Patane, Jose Salvatore L.; Proenga Guedes, Aureliano Coelho; de Souza, Robson F.; Silva-Pereira, Taiana T.; Soler Camargo, Naila C.; de Souza Filho, Antonio F.; Ikuta, Cassia Y.; Ferreira Neto, Jose Soares; Setubal, Joao Carlos; Heinemann, Marcos Bryan; Sa Guimaraes, Ana Marcia (2020-05-07)
      Mycobacterium bovis is the main causative agent of zoonotic tuberculosis in humans and frequently devastates livestock and wildlife worldwide. Previous studies suggested the existence of genetic groups of M. bovis strains ...
    • Dietary and Biological Assessment of the Omega-3 Status of Collegiate Athletes: A Cross-Sectional Analysis 

      Ritz, Peter P.; Rogers, Mark B.; Zabinsky, Jennifer S.; Hedric, Valisa E.; Rockwell, John A.; Rimef, Ernest G.; Kostelnik, Samantha B.; Hulver, Matthew W.; Rockwell, Michelle S. (PLOS, 2020-04-29)
      Omega-3 fatty acids (ω-3 FA) are associated with cardiovascular health, brain function, reduction of inflammation, and several other physiological roles of importance to competitive athletes. The ω-3 FA status of National ...
    • Characterization of a female germline and early zygote promoter from the transcription factor bZip1 in the dengue mosquito Aedes aegypti 

      Kojin, Bianca B.; Biedler, James K.; Tu, Zhijian; Adelman, Zach N. (2020-07-17)
      Background The wide distribution of Aedes aegypti, the main vector of dengue and yellow fever viruses, currently puts three billion people in the world at risk of infection with these viruses. Continuous transmission of ...