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Biochemical Characterization of a Dihydroneopterin Aldolase Used for Methanopterin Biosynthesis in Methanogens
(American Society for Microbiology, 2014-06-30)
The gene encoding 7,8-dihydroneopterin aldolase (DHNA) was recently identified in archaea through comparative genomics as being involved in methanopterin biosynthesis (V. Crecy-Lagard, G. Phillips, L. L. Grochowski, B. El ...
The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells
(The Royal Society of Chemistry, 2015-11-19)
Cancer progression and physiological changes within the cells are accompanied by alterations in the biophysical properties. Therefore, the cell biophysical properties can serve as promising markers for cancer detection and ...
Identification of a Unique Radical S-Adenosylmethionine Methylase Likely Involved in Methanopterin Biosynthesis in Methanocaldococcus jannaschii
(American Society for Microbiology, 2014-07-07)
Methanopterin (MPT) and its analogs are coenzymes required for methanogenesis and methylotrophy in specialized microorganisms. The methyl groups at C-7 and C-9 of the pterin ring distinguish MPT from all other pterin-containing ...
Identification of the Final Two Genes Functioning in Methanofuran Biosynthesis in Methanocaldococcus jannaschii
(American Society for Microbiology, 2015-06-22)
All methanofuran structural variants contain a basic core structure of 4-[N-(gamma -L-glutamyl)-p-(beta-aminoethyl) phenoxymethyl]( aminomethyl) furan (APMF-Glu) but have different side chains depending on the source ...
Evaluation of commercial floating treatment wetland technologies for nutrient remediation of stormwater
(Elsevier, 2013-12)
Floating treatment wetlands (FTWs) are a relatively new water treatment practice that consists of emergent wetland plants planted on floating mats constructed of buoyant material. This study utilized batch-fed mesocosms, ...
Near-Real-Time Analysis of the Phenotypic Responses of Escherichia coli to 1-Butanol Exposure Using Raman Spectroscopy
(American Society for Microbiology, 2014-08-25)
Raman spectroscopy was used to study the time course of phenotypic responses of Escherichia coli (DH5 alpha) to 1-butanol exposure (1.2% [vol/vol]). Raman spectroscopy is of interest for bacterial phenotyping because it ...
A Time Course for Susceptibility to Staphylococcus aureus Respiratory Infection during Influenza in a Swine Model.
(2011)
Bacterial superinfections following influenza A virus (IAV) are predominant causes of morbidity in humans. The recent emergence of methicillin-resistant Staphylococcus aureus (MRSA) and highly virulent IAV strains has ...
A Hidden Transhydrogen Activity of a FMN-Bound Diaphorase under Anaerobic Conditions
(PLOS, 2016-05-04)
Background
Redox cofactors of NADH/NADPH participate in many cellular metabolic pathways for facilitating the electron transfer from one molecule to another in redox reactions. Transhydrogenase plays an important role in ...
Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus
(BMC, 2017)
Background: PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression ...
Activation of SsoPK4, an Archaeal eIF2α Kinase Homolog, by Oxidized CoA
(MDPI, 2015-05-15)
The eukaryotic protein kinase (ePK) paradigm provides integral components for signal transduction cascades throughout nature<i>.</i> However, while so-called typical ePKs permeate the <i>Eucarya</i> and <i>Bacteria,</i> ...