Past research results include the following: • Modern CT scanners that use spiral-beam scanning and perform >100-million scans annually in the USA • Construction of the only 500nm resolution micro-CT system on the East Coast and the only 50nm nano-CT system with the interior tomography capability in the world from inside the walls of SAM-CT x-ray imaging facility • With further promise to handle large objects, reduce radiation dose, and improve temporal resolution, Interior tomography has already been extended to SPECT, MRI and other imaging modalities • A 3D analysis of the underlying molecular/cellular activities is taken from a mouse subject with an embedded bioluminescent source after an imaging model is built, linking the bioluminescent measurement and the source distribution.