Now showing items 1-4 of 4

    • Pregnancy and lactation interfere with the response of autoimmunity to modulation of gut microbiota 

      Mu, Qinghui; Cabana-Puig, Xavier; Mao, Jiangdi; Swartwout, Brianna; Abdelhamid, Leila; Cecere, Thomas E.; Wang, Haifeng; Reilly, Christopher M.; Luo, Xin M. (2019-07-16)
      Background Dysbiosis of gut microbiota exists in the pathogenesis of many autoimmune diseases, including systemic lupus erythematosus (lupus). Lupus patients who experienced pregnancy usually had more severe disease flares ...
    • Quaternary Ammonium Compound Disinfectants Reduce Lupus-Associated Splenomegaly by Targeting Neutrophil Migration and T-Cell Fate 

      Abdelhamid, Leila; Cabana-Puig, Xavier; Mu, Qinghui; Moarefian, Maryam; Swartwout, Brianna; Eden, Kristin; Das, Prerna; Seguin, Ryan P.; Xu, Libin; Lowen, Sarah; Lavani, Mital; Hrubec, Terry C.; Jones, Caroline N.; Luo, Xin M. (2020-10-21)
      Hypersensitivity reactions and immune dysregulation have been reported with the use of quaternary ammonium compound disinfectants (QACs). We hypothesized that QAC exposure would exacerbate autoimmunity associated with ...
    • Retinoic Acid Exerts Disease Stage-Dependent Effects on Pristane-Induced Lupus 

      Abdelhamid, Leila; Cabana-Puig, Xavier; Swartwout, Brianna; Lee, Jiyoung; Li, Song; Sun, Sha; Li, Yaqi; Ross, A. Catharine; Cecere, Thomas E.; LeRoith, Tanya; Werre, Stephen R.; Wang, Haifeng; Reilly, Christopher M.; Luo, Xin M. (2020-03-20)
      We previously showed that all-trans-retinoic acid (tRA), an active metabolite of vitamin A, exacerbated pre-existing autoimmunity in lupus; however, its effects before the development of autoimmunity are unknown. Here, ...
    • Retinoic Acid, Leaky Gut, and Autoimmune Diseases 

      Abdelhamid, Leila; Luo, Xin M. (MDPI, 2018-08-03)
      A leaky gut has been observed in a number of autoimmune diseases including type 1 diabetes, multiple sclerosis, inflammatory bowel disease, and systemic lupus erythematosus. Previous studies from our laboratory have shown ...