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Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9–39) in a normoglycemic mouse model
(Royal Society of Chemistry, 2016-05-12)
Prediabetes is a condition affecting 35% of US adults and about 50% of US adults age 65+. Foods rich in polyphenols, including flavanols and other flavonoids, have been studied for their putative beneficial effects on many ...
Remodeling Lipid Metabolism and Improving Insulin Responsiveness in Human Primary Myotubes
(PLOS, 2011-07-08)
Objective: Disturbances in lipid metabolism are strongly associated with insulin resistance and type 2 diabetes (T2D). We hypothesized that activation of cAMP/PKA and calcium signaling pathways in cultured human myotubes ...
Building Capacity for Data Driven Governance - Creating a New Foundation for Democracy
Existing data flows at the local level, public and administrative records, geospatial data, social media, surveys, as well as other federal, state, and local databases, are ubiquitous in our everyday life. These data, when ...
Quantifying Interhospital Patient Sharing as a Mechanism for Infectious Disease Spread
(University of Chicago Press, 2010-11)
BACKGROUND. Assessments of infectious disease spread in hospitals seldom account for interfacility patient sharing. This is particularly important for pathogens with prolonged incubation periods or carrier states.
METHODS. ...
Characterizing the Genetic Basis for Nicotine Induced Cancer Development: A Transcriptome Sequencing Study
(PLOS, 2013-06-18)
Nicotine is a known risk factor for cancer development and has been shown to alter gene expression in cells and tissue upon exposure. We used Illumina® Next Generation Sequencing (NGS) technology to gain unbiased biological ...
Systems Integration of Biodefense Omics Data for Analysis of Pathogen-Host Interactions and Identification of Potential Targets
(Public Library of Science, 2009-09-25)
The NIAID (National Institute for Allergy and Infectious Diseases) Biodefense Proteomics program aims to identify targets for potential vaccines, therapeutics, and diagnostics for agents of concern in bioterrorism, including ...
Psychosocial constructs were not mediators of intervention effects for dietary and physical activity outcomes in a church-based lifestyle intervention: Delta Body and Soul III
(2016-08)
Objective: Evaluating an intervention's theoretical basis can inform design modifications to produce more effective interventions. Hence the present study's purpose was to determine if effects from a multicomponent lifestyle ...
Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR⁻/⁻ mice
(ASBMB, 2012-07-29)
Fish oil (FO) is a potent anti-inflammatory and lipid-lowering agent. Because inflammation can modulate lipid metabolism and vice versa, we hypothesized that combining FO with cyclooxygenase inhibitors (COXIBs), well-known ...
The Theory of Reasoned Action as Parallel Constraint Satisfaction: Towards a Dynamic Computational Model of Health Behavior
(PLOS, 2013-05-03)
The reasoned action approach, although ubiquitous in health behavior theory (e.g., Theory of Reasoned Action/Planned Behavior), does not adequately address two key dynamical aspects of health behavior: learning and the ...