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dc.date.accessioned2019-02-26T22:24:05Zen
dc.date.available2019-02-26T22:24:05Zen
dc.date.issued2018-10-16en
dc.identifier.urihttp://hdl.handle.net/10919/87851en
dc.description.abstractSphingosine kinases are enzymes that catalyze the biosynthesis of sphingosine-1-phosphate. The invention provides compounds that are effective for inhibition of sphingosine kinase type 1, sphingosine kinase type 2, or both. Certain compounds are selective for sphingosine kinase type 2 relative to sphingosine kinase type 1. Compounds of the invention can be used in treatment of a range of diseases wherein increasing the level of sphingosine-1-phosphate in blood is medically indicated. Diseases that can be treated by administration of an effective dose of a compound of the invention include a neoplastic disease that involves excess vascular growth; macular degeneration or diabetic retinopathy; an allergic disease such as asthma, an inflammatory disease of the eye such as uveitis, scleritis, or vitritis; an inflammatory disease of the kidney; a fibrotic disease; atherosclerosis; or pulmonary arterial hypertension. A compound of the invention can be used to improve the integrity of a vascular barrier in a disease where the vascular barrier is disrupted, such as cancer or Alzheimer's disease.en
dc.format.mimetypeapplication/pdfen
dc.language.isoen_USen
dc.publisherUnited States Patent and Trademark Officeen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleSphingosine kinase inhibitorsen
dc.typePatenten
dc.contributor.departmentChemistryen
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/22/000/101/0.pdfen
dc.date.accessed2019-02-15en
dc.type.dcmitypeTexten
dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.assigneeUniversity of Virginia Patent Foundationen
dc.contributor.inventorLynch, Kevin R.en
dc.contributor.inventorSantos, Webster L.en
dc.date.filed2015-09-30en
dc.identifier.applicationnumber15516333en
dc.subject.cpcA61K31/03en
dc.subject.cpcA61K31/42en
dc.subject.cpcC07D271/06en
dc.subject.cpcC07C279/16en
dc.subject.cpcC07D249/08en
dc.subject.cpcC07D285/12en
dc.subject.cpcC07D413/04en
dc.subject.cpcC07D413/14en
dc.subject.cpcC07D417/04en
dc.type.patenttypeutilityen
dc.identifier.patentnumber10100022en


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