Show simple item record

dc.contributor.authorO’Brien, T. J.en
dc.contributor.authorBonakdar, Mohammaden
dc.contributor.authorBhonsle, Suyashree P.en
dc.contributor.authorNeal, Robert E.en
dc.contributor.authorAardema, C.H.en
dc.contributor.authorRobertson, John L.en
dc.contributor.authorGoldberg, S.N.en
dc.contributor.authorDavalos, Rafael V.en
dc.date.accessioned2019-04-09T13:14:35Zen
dc.date.available2019-04-09T13:14:35Zen
dc.date.issued2018-05-28en
dc.identifier.issn0265-6736en
dc.identifier.urihttp://hdl.handle.net/10919/88874en
dc.description.abstractPurpose: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and temperature changes using a perfused porcine liver model. Materials and methods: A bipolar electrode delivered IRE electric pulses with or without activation of internal cooling to nine porcine mechanically perfused livers. Pulse schemes included a constant voltage, and a preconditioned delivery combined with an arc-mitigation algorithm. After treatment, organs were dissected, and treatment zones were stained using triphenyl-tetrazolium chloride (TTC) to demonstrate viability. Results: Thirty-nine treatments were performed with an internally cooled applicator and 21 with a non-cooled applicator. For the constant voltage scenario, the average final electrical current measured was 26.37 and 29.20 A for the cooled and uncooled electrodes respectively (p≤.001). The average final temperature measured was 33.01 and 42.43 °C for the cooled and uncooled electrodes respectively (p≤.0001). The average measured ablations (fixed lesion) were 3.88-by-2.08 cm and 3.86-by-2.12 cm for the cooled and uncooled electrode respectively (p≤.2495, p≤.7507). Similarly, the preconditioned/arc-mitigation scenario yielded an average final electrical current measurement of a 41.07 and 47.20 A for the cooled and uncooled electrodes respectively (p≤.0001). The average final temperature measured was 34.93 and 44.90 °C for the cooled and uncooled electrodes respectively (p≤.0001). The average measured ablations (fixed lesion) were 3.67-by-2.27 cm and 3.58-by-2.09 cm for the cooled and uncooled applicators ((p≤.7906; p≤.5595)). Conclusions: The internally-cooled bipolar applicator offers advantages that could improve clinical outcomes. Thermally mitigating internal perfusion technology reduced tissue temperatures and electric current while maintaining similar lesion sizes.en
dc.format.mimetypeapplication/pdfen
dc.language.isoen_USen
dc.publisherTaylor and Francis Ltden
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectarc mitigationen
dc.subjectcurrenten
dc.subjectIrreversible electroporationen
dc.subjectperfused organ modelen
dc.subjecttemperatureen
dc.subjectthermal damageen
dc.subjectthermal mitigationen
dc.titleEffects of internal electrode cooling on irreversible electroporation using a perfused organ modelen
dc.typeArticle - Refereeden
dc.description.notesThis study was supported in part by AngioDynamics Inc. and the Pancreatic Cancer Action Network Translational Research Grant [PanCAN 16–65-IANN]. The authors would also like to acknowledge support from the Institute for Critical Technology and Applied Science (ICTAS) and its Center for Engineered Health (CEH) of Virginia Tech.en
dc.title.serialInternational Journal of Hyperthermiaen
dc.identifier.doihttps://doi.org/10.1080/02656736.2018.1473893en
dc.identifier.volume35en
dc.identifier.issue1en
dc.type.dcmitypeTexten
dc.identifier.pmid29806513en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International