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Regulation of neonatal IgA production by the maternal microbiota

Mu, Qinghui; Swartwout, Brianna K.; Edwards, Michael; Zhu, Jing; Lee, Grace; Eden, Kristin; Cabana-Puig, Xavier; McDaniel, Dylan K.; Mao, Jiangdi; Abdelhamid, Leila; Brock, Rebecca M.; Allen, Irving Coy; Reilly, Christopher M.; Luo, Xin M. (National Academy of Sciences, 2021-02-22)

Infants are prone to enteric infections due to an underdeveloped immune system. The maternal microbiota, through shaping the neonatal microbiota, helps establish a strong immune system in infants. We and others have observed ...

Tracheostomy and Gastrostomy in Geriatric Trauma Associated With High Postdischarge Mortality

Boone, Sherry M.; Collier, Bryan R.; Faulks, Emily R.; Locklear, Tonja M.; Bower, Katie L.; Lollar, Daniel I.; Dhiman, Nitasha; Nussbaum, Michael S.; Hamill, Mark E. (Wolters Kluwer Health, Inc., 2020)

The purpose of this study was to assess the long-term mortality of adult and geriatric trauma patients who undergo tracheostomy and/or gastrostomy tube placement after severe trauma. Our hypothesis is that geriatric trauma ...

Calculating an institutional personal protective equipment (PPE) burn rate to project future usage patterns during the 2020 COVID-19 pandemic

Raja, Sumanth; Patolia, Harsh H.; Baffoe-Bonnie, Anthony W. (2020-12)

Quantitative Proteomics Reveals the Beneficial Effects of Low Glucose on Neuronal Cell Survival in an in vitro Ischemic Penumbral Model

Li, Hua; Kittur, Farooqahmed S.; Hung, Chiu-Yueh; Li, P. Andy; Ge, Xinghong; Sane, David C.; Xie, Jiahua (2020-09-01)

Understanding proteomic changes in the ischemic penumbra are crucial to rescue those salvageable cells and reduce the damage of an ischemic stroke. Since the penumbra region is dynamic with heterogeneous cells/tissues, ...

Immunomodulation and Generation of Tolerogenic Dendritic Cells by Probiotic Bacteria in Patients with Inflammatory Bowel Disease

Ghavami, Shaghayegh Baradaran; Yadegar, Abbas; Aghdaei, Hamid Asadzadeh; Sorrentino, Dario; Farmani, Maryam; Mir, Adil Shamim; Azimirad, Masoumeh; Balaii, Hedieh; Shahrokh, Shabnam; Zali, Mohammad Reza (2020-09)

In inflammatory bowel diseases (IBD), the therapeutic benefit and mucosal healing from specific probiotics may relate to the modulation of dendritic cells (DCs). Herein, we assessed the immunomodulatory effects of four ...

Lithium toxicity following bariatric surgery

Jamison, Suzanna Connick; Aheron, Kelley (2020-09)

A patient with morbid obesity and several psychiatric comorbidities underwent laparoscopic sleeve gastrectomy and experienced success with weight loss. However, she experienced lightheadedness, nausea, and a fall and was ...

Elevated perfusate [Na+] increases contractile dysfunction during ischemia and reperfusion

King, D. Ryan; Padget, Rachel L.; Perry, Justin; Hoeker, Gregory; Smyth, James W.; Brown, David A.; Poelzing, Steven (2020-10-14)

Recent studies revealed that relatively small changes in perfusate sodium ([Na+](o)) composition significantly affect cardiac electrical conduction and stability in contraction arrested ex vivo Langendorff heart preparations ...

McArdle Disease vs. Stiff-Person Syndrome: A Case Report Highlighting the Similarities Between Two Rare and Distinct Disorders

Godbe, Kerilyn; Malaty, Giovanni; Wenzel, Alyssa; Nazeer, Sahana; Grider, Douglas J.; Kinsey, Adrienne (2020-11-10)

McArdle disease is a rare autosomal recessive disorder of muscle glycogen metabolism that presents with pain and fatigue during exercise. Stiff-Person Syndrome is an autoimmune-related neurologic process characterized by ...

Gut Microbiota and Bacterial DNA Suppress Autoimmunity by Stimulating Regulatory B Cells in a Murine Model of Lupus

Mu, Qinghui; Edwards, Michael R.; Swartwout, Brianna K.; Cabana Puig, Xavier; Mao, Jiangdi; Zhu, Jing; Grieco, Joe; Cecere, Thomas E.; Prakash, Meeta; Reilly, Christopher M.; Puglisi, Christopher; Bachali, Prathyusha; Grammer, Amrie C.; Lipsky, Peter E.; Luo, Xin M. (2020-11-10)

Autoimmune diseases, such as systemic lupus erythematosus, are characterized by excessive inflammation in response to self-antigens. Loss of appropriate immunoregulatory mechanisms contribute to disease exacerbation. We ...