Fralin Biomedical Research Institute at VTC
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The Fralin Biomedical Research Institute was named in 2019, and was formerly the Virginia Tech Carilion Research Institute.
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Scholarly Works, Fralin Biomedical Research Institute at VTC [293]
Research articles, presentations, and other scholarship
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Axillary enlargement in gestational gigantomastia, an uncommon presentation of a rare disease. A case report
(2020-05-19)BACKGROUND: Gestational gigantomastia presents in pregnancy as a rapid and excessive enlargement of the breast reducing the quality of life and causing psychological and physical impairment. Huge axillary enlargement due ... -
Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity
(Frontiers Media, 2021-01-11)Connexins are transmembrane proteins that form hemichannels allowing the exchange of molecules between the extracellular space and the cell interior. Two hemichannels from adjacent cells dock and form a continuous gap ... -
A pilot randomized controlled trial of a tailored smoking cessation program for people living with HIV in the Washington, D.C. metropolitan area
(2021-01-06)Abstract Objective Morbidity and mortality from smoking-related diseases among people living with HIV (PLWH) in the U.S. surpasses that due to HIV itself. Conventional smoking ... -
Opponent Effects of Hyperarousal and Re-experiencing on Affective Habituation in Posttraumatic Stress Disorder
(2020-02)BACKGROUND: Aberrant emotion processing is a hallmark of posttraumatic stress disorder (PTSD), with neurobiological models suggesting both heightened neural reactivity and diminished habituation to aversive stimuli. However, ... -
Retinal inputs signal astrocytes to recruit interneurons into visual thalamus
(2020-02-04)Inhibitory interneurons comprise a fraction of the total neurons in the visual thalamus but are essential for sharpening receptive field properties and improving contrast-gain of retinogeniculate transmission. During early ... -
Transcriptional dysregulation in developing trigeminal sensory neurons in the LgDel mouse model of DiGeorge 22q11.2 deletion syndrome
(2020-03-15)LgDel mice, which model the heterozygous deletion of genes at human chromosome 22q11.2 associated with DiGeorge/22q11.2 deletion syndrome (22q11DS), have cranial nerve and craniofacial dysfunction as well as disrupted ... -
Antitumor Activity of Curcumin in Glioblastoma
(MDPI, 2020-12-11)Current standard-of-care treatment for glioblastoma, the most common malignant primary central nervous system (CNS) tumor, consists of surgical resection followed by adjuvant chemotherapy and radiation (Stupp protocol), ... -
Multidirectional Pathways between Attachment, Mentalizing, and Posttraumatic Stress Symptomatology in the Context of Childhood Trauma
(2020-05)Introduction:Exposure to traumatic stressful events in childhood is an important risk factor for the development of posttraumatic symptomatology. From a mentalization-based developmental perspective, childhood adversity ... -
Variations in maternal vitamin A intake modifies phenotypes in a mouse model of 22q11.2 deletion syndrome
(2020-10)Background Vitamin A regulates patterning of the pharyngeal arches, cranial nerves, and hindbrain that are essential for feeding and swallowing. In the LgDel mouse model of 22q11.2 deletion syndrome (22q11DS), morphogenesis ... -
Episodes of strain experienced in the operating room: impact of the type of surgery, the profession and the phase of the operation
(2020-12-07)Abstract Background Strain episodes, defined as phases of higher workload, stress or negative emotions, occur everyday in the operating room (OR). Accurate knowledge of when strain is most intense for the different OR ... -
Applying Experiential Learning to Career Development Training for Biomedical Graduate Students and Postdocs: Perspectives on Program Development and Design
(2020-09)Experiential learning is an effective educational tool across many academic disciplines, including career development. Nine different institutions bridged by the National Institutes of Health Broadening Experiences in ... -
Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation
(MDPI, 2020-12-10)Barrier function is a vital homeostatic mechanism employed by epithelial and endothelial tissue. Diseases across a wide range of tissue types involve dynamic changes in transcellular junctional complexes and the actin ... -
Molecular Imaging of Brain Tumor-Associated Epilepsy
(MDPI, 2020-12-05)Epilepsy is a common clinical manifestation and a source of significant morbidity in patients with brain tumors. Neuroimaging has a pivotal role in neuro-oncology practice, including tumor detection, differentiation, ... -
The Benefits of Vitamin D Supplementation for Athletes: Better Performance and Reduced Risk of COVID-19
(MDPI, 2020-12-04)The COVID-19 pandemic is having major economic and personal consequences for collegiate and professional sports. Sporting events have been canceled or postponed, and even when baseball and basketball seasons resumed in the ... -
Underlying Principles of a Covid-19 Behavioral Vaccine for a Sustainable Cultural Change
(MDPI, 2020-12-04)Until pharmacological measures are effective at containing the COVID-19 outbreak, adopting protective behaviors is paramount. In this work, we aim at informing interventions to limit the spread of the contagion and prepare ... -
DNA Double-Strand Breaks Are a Critical Regulator of Fear Memory Reconsolidation
(MDPI, 2020-11-26)Numerous studies have shown that following retrieval, a previously consolidated memory requires increased transcriptional regulation in order to be reconsolidated. Previously, it was reported that histone H3 lysine-4 ... -
Valuation of peers’ safe choices is associated with substance-naïveté in adolescents
(National Academy of Sciences, 2020-11-30)Social influences on decision-making are particularly pronounced during adolescence and have both protective and detrimental effects. To evaluate how responsiveness to social signals may be linked to substance use in ... -
Disrupted Coordination of Hypoglossal Motor Control in a Mouse Model of Pediatric Dysphagia in DiGeorge/22q11.2 Deletion Syndrome
(Society for Neuroscience, 2020)We asked whether the physiological and morphologic properties of hypoglossal motor neurons (CNXII MNs) that innervate protruder or retractor tongue muscles are disrupted in neonatal LgDel mice that carry a heterozygous ... -
The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats
(2020-07-17)Allen and Pennington et al. show that the cardiolipin-binding peptide elamipretide mitigates disease-induced fragmentation of cristae networks following cardiac ischemia reperfusion in rats. This study suggests that ... -
Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making
(CellPress, 2020-12-09)Recent animal research indicates that dopamine and serotonin, neuromodulators traditionally linked to appetitive and aversive processes, are also involved in sensory inference and decisions based on such inference. We ...
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