Browsing Scholarly Works, Fralin Biomedical Research Institute at VTC by Title
Now showing items 97-116 of 304
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Early childhood investment impacts social decision-making four decades later
(Nature Research, 2018-11-20)Early childhood educational investment produces positive effects on cognitive and non-cognitive skills, health, and socio-economic success. However, the effects of such interventions on social decision-making later in life ... -
The effect of a connexin43-based Peptide on the healing of chronic venous leg ulcers: a multicenter, randomized trial.
(2015-01)The gap junction protein, connexin43 (Cx43), has critical roles in the inflammatory, edematous, and fibrotic processes following dermal injury and during wound healing, and is abnormally upregulated at the epidermal wound ... -
Effect of Various OR Noise on Fine Motor Skills, Cognition, and Mood
(Hindawi, 2019-07-04)Background. The amalgam of noises inherent to the modern-day operating room has the potential of diluting surgeon concentration, which could affect surgeon performance and mood and have implications on quality of care and ... -
Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity
(Frontiers Media, 2021-01-11)Connexins are transmembrane proteins that form hemichannels allowing the exchange of molecules between the extracellular space and the cell interior. Two hemichannels from adjacent cells dock and form a continuous gap ... -
Effects of the probiotic lactobacillus animalis in murine mycobacterium avium subspecies paratuberculosis infection
(2013-01-16)Background MAP is a suspected zoonotic pathogen and the causative agent of Johne’s Disease in cattle and other ruminant animals. With over $1 billion dollars in loss to the dairy industry due to Johne’s Disease, efforts ... -
EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
(2019-08-29)Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we ... -
Electrophysiologic effects of the I-K1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts
(The Physiological Society, 2017-01)The pentamidine analog PA-6 was developed as a specific inward rectifier potassium current (I-K1) antagonist, because established inhibitors either lack specificity or have side effects that prohibit their use in vivo. We ... -
Elevated perfusate [Na+] increases contractile dysfunction during ischemia and reperfusion
(2020-10-14)Recent studies revealed that relatively small changes in perfusate sodium ([Na+](o)) composition significantly affect cardiac electrical conduction and stability in contraction arrested ex vivo Langendorff heart preparations ... -
Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics
(MDPI, 2019-12-13)Metabolomics is the latest ‘omics’ technology and systems biology science that allows for comprehensive profiling of small-molecule metabolites in biological systems at a specific time and condition. Metabolites ... -
Emerging therapeutic roles for NAD⁺ metabolism in mitochondrial and age‑related disorders
(Springer, 2016-07-27)Nicotinamide adenine dinucleotide (NAD⁺) is a central metabolic cofactor in eukaryotic cells that plays a critical role in regulating cellular metabolism and energy homeostasis. NAD⁺ in its reduced form (i.e. NADH) serves ... -
Episodes of strain experienced in the operating room: impact of the type of surgery, the profession and the phase of the operation
(2020-12-07)Abstract Background Strain episodes, defined as phases of higher workload, stress or negative emotions, occur everyday in the operating room (OR). Accurate knowledge of when strain is most intense for the different OR ... -
EvoCor: a platform for predicting functionally related genes using phylogenetic and expression profiles
(2014-07-01)The wealth of publicly available gene expression and genomic data provides unique opportunities for computational inference to discover groups of genes that function to control specific cellular processes. Such genes are ... -
Explaining racial and ethnic inequalities in postpartum allostatic load: Results from a multisite study of low to middle income women
(Elsevier, 2016-12)Background: Racial and ethnic inequalities in women's health are widely documented, but not for the postpartum period, and few studies examine whether neighborhood, psychosocial, and biological factors explain these gaps ... -
Exploring the Potential Role of Inflammation as an Etiological Process in ASD
(2015-09)The heterogeneity in the behavioral presentation of autism spectrum disorder (ASD) may be surpassed only by the level of heterogeneity in its etiology. There are diverse pathways to the singular diagnostic outcome of ASD, ... -
Exposure of Rats to Environmental Tobacco Smoke during Cerebellar Development Alters Behavior and Perturbs Mitochondrial Energetics
(National Institute of Environmental Health Sciences, 2012-12)Background: Environmental tobacco smoke (ETS) exposure is linked to developmental deficits and disorders with known cerebellar involvement. However, direct biological effects and underlying neurochemical mechanisms remain ... -
F-spondin Is Essential for Maintaining Circadian Rhythms
(Frontiers, 2018-02-08)The suprachiasmatic nucleus (SCN) is the master pacemaker that drives circadian behaviors. SCN neurons have intrinsic, self-sustained rhythmicity that is governed by transcription-translation feedback loops. Intrinsic ... -
Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity
(MDPI, 2021-04-06)Prior work suggests that actual, but not estimated, energy density drives the reinforcing value of food and that energy from fat and carbohydrate can interact to potentiate reward. Here we sought to replicate these findings ... -
Fibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleus
(Frontiers, 2012-01-10)At least three forms of signaling between pre- and postsynaptic partners are necessary during synapse formation. First, “targeting” signals instruct presynaptic axons to recognize and adhere to the correct portion of a ... -
Functional and cognitive status in Clostridium difficile infection in the hospitalized elderly: A Retrospective Study of Two Sites
(Springer, 2019-03-20)Advanced age is a risk factor for Clostridium difficile infection (CDI), and older patients have more severe CDI and worse outcome [1-3]. We investigated whether CDI in the elderly is associated with functional and cognitive ... -
The Functional Architecture of the Brain Underlies Strategic Deception in Impression Management
(Frontiers, 2017-11-02)Impression management, as one of the most essential skills of social function, impacts one’s survival and success in human societies. However, the neural architecture underpinning this social skill remains poorly understood. ...
