Browsing Scholarly Works, Fralin Biomedical Research Institute at VTC by Title
Now showing items 151-170 of 300
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Keeping up with the Joneses: Interpersonal Prediction Errors and the Correlation of Behavior in a Tandem Sequential Choice Task
(Public Library of Science, 2013-10-24)In many settings, copying, learning from or assigning value to group behavior is rational because such behavior can often act as a proxy for valuable returns. However, such herd behavior can also be pathologically misleading ... -
Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction
(The Rockefeller University Press, 2008-09-15)A prominent feature of synaptic maturation at the neuromuscular junction (NMJ) is the topological transformation of the acetylcholine receptor (AChR)-rich postsynaptic membrane from an ovoid plaque into a complex array of ... -
A large-scale RNA interference screen identifies genes that regulate autophagy at different stages
(Nature Publishing Group, 2018-02-12)Dysregulated autophagy is central to the pathogenesis and therapeutic development of cancer. However, how autophagy is regulated in cancer is not well understood and genes that modulate cancer autophagy are not fully ... -
Lessons learned from implementing the patient-centered medical home.
(Hindawi, 2012)The Patient-Centered Medical Home (PCMH) is a primary care model that provides coordinated and comprehensive care to patients to improve health outcomes. This paper addresses practical issues that arise when transitioning ... -
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns
(Rockefeller Univ Press, 2011-05-09) -
Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo
(MDPI, 2021-03-11)Sonic hedgehog subtype of medulloblastoma (SHH MB) with metastasis or specific clinical or molecular alteration shas a poor prognosis and current therapy results in long-term cognitive impairment in the majority of survivors. ... -
Localization and local translation of Arc/Arg3.1 mRNA at synapses: some observations and paradoxes
(Frontiers, 2015-01-12)Arc is a unique immediate early gene whose expression is induced as synapses are being modified during learning. The uniqueness comes from the fact that newly synthesized Arc mRNA is rapidly transported throughout dendrites ... -
Longitudinal link between trait motivation and risk-taking behaviors via neural risk processing
(2019-12)Prior research has emphasized the importance of the motivational system in risky decision-making, yet the mechanisms through which individual differences in motivation may influence adolescents' risk-taking behaviors remain ... -
Low Dose Infliximab for Prevention of Postoperative Recurrence of Crohn's Disease: Long Term Follow-Up and Impact of Infliximab Trough Levels and Antibodies to Infliximab
(PLOS, 2015-12-15)Objective In patients with postoperative recurrence of Crohn’s disease endoscopic and clinical remission can be maintained for up to 1 year with low infliximab doses (3 mg/Kg). However, in theory low-dose infliximab ... -
LRRTM1 underlies synaptic convergence in visual thalamus
(eLife, 2018-02-09)It has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted ... -
LTD Induction in Adult Visual Cortex: Role of Stimulus Timing and Inhibition
(Society for Neuroscience, 2001-04-01)One Hertz stimulation of afferents for 15 min with constant interstimulus intervals (regular stimulation) can induce longterm depression (LTD) of synaptic strength in the neocortex. However, it is unknown whether natural ... -
Male Carriers of the FMR1 Premutation Show Altered Hippocampal-Prefrontal Function During Memory Encoding
(Frontiers Media S.A., 2012-10-30)Previous functional MRI (fMRI) studies have shown that fragile X mental retardation 1 (FMR1) premutation allele carriers (FXPCs) exhibit decreased hippocampal activation during a recall task and lower inferior frontal ... -
Mathematically Gifted Adolescents Have Deficiencies in Social Valuation and Mentalization
(PLOS, 2011-04-04)Many mathematically gifted adolescents are characterized as being indolent, underachieving and unsuccessful despite their high cognitive ability. This is often due to difficulties with social and emotional development. ... -
Methicillin-Susceptible Staphylococcus aureus as a Predominantly Healthcare-Associated Pathogen: A Possible Reversal of Roles?
(PLoS, 2011-04-13)Background
Methicillin-resistant Staphylococcus aureus (MRSA) strains have become common causes of skin and soft tissue infections (SSTI) among previously healthy people, a role of methicillin-susceptible (MSSA) ... -
A microchip platform for structural oncology applications.
Recent advances in the development of functional materials offer new tools to dissect human health and disease mechanisms. The use of tunable surfaces is especially appealing as substrates can be tailored to fit applications ... -
Microfluidic reactors for advancing the MS analysis of fast biological responses
(Nature Publishing Group, 2019-02-11)The response of cells to physical or chemical stimuli is complex, unfolding on time-scales from seconds to days, with or without de novo protein synthesis, and involving signaling processes that are transient or sustained. ... -
Microvascular bioengineering: a focus on pericytes
(2019-03-29)Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste exchange, among other critical functions. Microvascular bioengineering approaches have sought to recapitulate many key features ... -
Mindfulness meditation modulates reward prediction errors in a passive conditioning task
(Frontiers, 2015-02-12)Reinforcement learning models have demonstrated that phasic activity of dopamine neurons during reward expectation encodes information about the predictability of reward and cues that predict reward. Self-control strategies ... -
Minor defects of the luminal integrity in arterial introducer eSheaths after transcatheter aortic valve implantation
(PLOS, 2017-05-08)Background Medical devices such as implant delivery systems are commonly used during minimally invasive procedures in the cardiovascular system. These devices often have lubricious polymer coatings to reduce friction ... -
Mismatch Responses in the Awake Rat: Evidence from Epidural Recordings of Auditory Cortical Fields
(PLOS, 2013-04-30)Detecting sudden environmental changes is crucial for the survival of humans and animals. In the human auditory system the mismatch negativity (MMN), a component of auditory evoked potentials (AEPs), reflects the violation ...
