Browsing Scholarly Works, Fralin Biomedical Research Institute at VTC by Title
Now showing items 230-249 of 300
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Quantitative Variation in m.3243A > G Mutation Produce Discrete Changes in Energy Metabolism
(Springer Nature, 2019-04-08)Mitochondrial DNA (mtDNA) 3243A > G tRNALeu((UUR)) heteroplasmic mutation (m.3243A > G) exhibits clinically heterogeneous phenotypes. While the high mtDNA heteroplasmy exceeding a critical threshold causes mitochondrial ... -
The Rametrix (TM) PRO Toolbox v1.0 for MATLAB (R)
(2020-01-06)Background. Existing tools for chemometric analysis of vibrational spectroscopy data have enabled characterization of materials and biologicals by their broad molecular composition. The Rametrix (TM) LITE Toolbox v1.0 for ... -
A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications
(Taylor & Francis Inc, 2015-03-01)The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a variety of human diseases. To address this critical issue, we developed ... -
Ready…Go: Amplitude of the fMRI Signal Encodes Expectation of Cue Arrival Time
(PLOS, 2009-08-04)What happens when the brain awaits a signal of uncertain arrival time, as when a sprinter waits for the starting pistol? And what happens just after the starting pistol fires? Using functional magnetic resonance imaging ... -
Recapitulation of an ion channel IV curve using frequency components.
(2011-02-08)INTRODUCTION: Presently, there are no established methods to measure multiple ion channel types simultaneously and decompose the measured current into portions attributable to each channel type. This study demonstrates how ... -
Recombinant asialoerythropoetin protects HL-1 cardiomyocytes from injury via suppression of Mst1 activation
(Elsevier B.V., 2019-01-09)Background: Recombinant human erythropoietin (rhuEPO) and asialoerythropoietin (asialo-rhuEPO) are cardioprotective. However, the protective effects of rhuEPO could not be translated into clinical practice because of its ... -
Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders
(PLOS, 2015-07-06)Burkholderia pseudomallei and Burkholderia mallei are the etiologic agents of melioidosis and glanders, respectively. These bacteria are highly infectious via the respiratory route and can cause severe and often fatal ... -
Redesigning a Neuroscience Laboratory Course for Multiple Sections: An Action Research Project to Engage Students
(Faculty of Undergraduate Neuroscience, 2017-06-15)The purpose of our action research project was to improve students’ motivation in a multi-section introductory neuroscience laboratory course. In this paper, we present: (a) how we collected data related to students’ ... -
Region- and Cell-Specific Expression of Transmembrane Collagens in Mouse Brain
(Frontiers, 2017-08-30)Unconventional collagens are nonfribrillar proteins that not only contribute to the structure of extracellular matrices but exhibit unique bio-activities. Although roles for unconventional collagens have been well-established ... -
Regret Expression and Social Learning Increases Delay to Sexual Gratification
(PLOS, 2015-08-17)Objective Modification and prevention of risky sexual behavior is important to individuals’ health and public health policy. This study employed a novel sexual discounting task to elucidate the effects of social learning ... -
The Reliability and Validity of the Loadsol® under Various Walking and Running Conditions
(MDPI, 2019-01-11)The assessment of loading during walking and running has historically been limited to data collection in laboratory settings or with devices that require a computer connection. This study aims to determine if the ... -
Remote Alcohol Monitoring to Facilitate Incentive-Based Treatment for Alcohol Use Disorder: A Randomized Trial
(2018-12)B ackground: The delivery of monetary incentives contingent on verified abstinence is an effective treatment for alcohol use disorder. However, technological barriers to accurate, frequent biochemical verification of alcohol ... -
Remote Excitation of Neuronal Circuits Using Low- Intensity, Low-Frequency Ultrasound
(PLOS, 2008-10-29)Possessing the ability to noninvasively elicit brain circuit activity yields immense experimental and therapeutic power. Most currently employed neurostimulation methods rely on the somewhat invasive use of stimulating ... -
Retinal inputs signal astrocytes to recruit interneurons into visual thalamus
(2020-02-04)Inhibitory interneurons comprise a fraction of the total neurons in the visual thalamus but are essential for sharpening receptive field properties and improving contrast-gain of retinogeniculate transmission. During early ... -
Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus
(2019-02-14)DNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in understanding the maturation ... -
RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome.
(2017)BACKGROUND: Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 function is derived from transcriptomic studies with ... -
The Role of Class IA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunits in Glioblastoma
(Frontiers, 2017-12-15)Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) plays a critical role in the pathogenesis of cancer including glioblastoma, the most common and aggressive form of brain cancer. Targeting the PI3K pathway to treat ... -
Role of GABAA-Mediated Inhibition and Functional Assortment of Synapses onto Individual Layer 4 Neurons in Regulating Plasticity Expression in Visual Cortex
(PLOS, 2016-02-03)Layer 4 (L4) of primary visual cortex (V1) is the main recipient of thalamocortical fibers from the dorsal lateral geniculate nucleus (LGNd). Thus, it is considered the main entry point of visual information into the ... -
The Role of Muscle microRNAs in Repairing the Neuromuscular Junction
(PLOS, 2014-03-24)microRNAs have been implicated in mediating key aspects of skeletal muscle development and responses to diseases and injury. Recently, we demonstrated that a synaptically enriched microRNA, miR-206, functions to promote ... -
The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target
(Elsevier, 2018-09-19)Cardiovascular disease remains the single largest cause of natural death in the United States, with a significant cause of mortality associated with cardiac arrhythmias. Presently, options for treating and preventing ...
