Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor

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dc.contributor.authorMograbi, Madisonen
dc.contributor.authorStump, Michael S.en
dc.contributor.authorLuyimbazi, David T.en
dc.contributor.authorShakhatreh, Mohammad H.en
dc.contributor.authorGrider, Douglas J.en
dc.date.accessioned2019-12-23T13:30:42Zen
dc.date.available2019-12-23T13:30:42Zen
dc.date.issued2019-12-05en
dc.date.updated2019-12-23T13:25:42Zen
dc.description.abstractFollicular dendritic cell sarcoma (FDCS) is a rare and underdiagnosed malignant neoplasm which characteristically presents as a solitary, slow-growing mass with no discrete symptoms. Histologically, lymphocytes and spindle cells featuring large nucleoli in a whorled pattern are usually seen. FDCS is classically found in cervical and axillary lymph nodes, with occasional involvement of extranodal sites. Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDCT) is an uncommon subcategory of this neoplasm, demonstratively linked to the Epstein-Barr virus (EBV). This neoplasm can present similarly to FDCS, but systemic symptoms may be seen. Although, often found in the spleen and occasionally the liver, IPT-like FDCT has not previously been described within the pancreas. Presented, is an IPT-like FDCT of the pancreas and spleen of a 70 years old woman. Histologic features include variably sized geographic suppurative granulomas with chronic inflammatory cells and an atypical spindle cell proliferation with prominent nucleoli. Positivity for CD45 and CD68 in the larger spindled cells points to an inflammatory pseudotumor subtype and co-expression of CD21, CD23, and CD35 were indicative of follicular dendritic differentiation. The pseudotumor additionally demonstrated EBV-encoded RNA (EBER) positivity typical of IPT-like FDCT. Differentiation between inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT) is additionally discussed.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMadison Mograbi, Michael S. Stump, David T. Luyimbazi, Mohammad H. Shakhatreh, and Douglas J. Grider, “Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor,” Case Reports in Pathology, vol. 2019, Article ID 2648123, 5 pages, 2019. doi:10.1155/2019/2648123en
dc.identifier.doihttps://doi.org/10.1155/2019/2648123en
dc.identifier.urihttp://hdl.handle.net/10919/96203en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2019 Madison Mograbi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titlePancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumoren
dc.title.serialCase Reports in Pathologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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