Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic β-Cell Mass in Middle-Aged Obese Diabetic Mice

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dc.contributor.authorAlkhalidy, Hanaen
dc.contributor.authorMoore, William B.en
dc.contributor.authorZhang, Yanlingen
dc.contributor.authorMcMillan, Ryan P.en
dc.contributor.authorWang, Aihuaen
dc.contributor.authorAli, Mostafaen
dc.contributor.authorSuh, Kyung-Shinen
dc.contributor.authorZhen, Weien
dc.contributor.authorCheng, Zhiyongen
dc.contributor.authorJia, Zhenquanen
dc.contributor.authorHulver, Matthew W.en
dc.contributor.authorLiu, Dongminen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2017-09-18T09:39:49Zen
dc.date.available2017-09-18T09:39:49Zen
dc.date.issued2015-05-07en
dc.date.updated2017-09-18T09:39:49Zen
dc.description.abstractInsulin resistance and a progressive decline in functional β-cell mass are hallmarks of developing type 2 diabetes (T2D). Thus, searching for natural, low-cost compounds to target these two defects could be a promising strategy to prevent the pathogenesis of T2D. Here, we show that dietary intake of flavonol kaempferol (0.05% in the diet) significantly ameliorated hyperglycemia, hyperinsulinemia, and circulating lipid profile, which were associated with the improved peripheral insulin sensitivity in middle-aged obese mice fed a high-fat (HF) diet. Kaempferol treatment reversed HF diet impaired glucose transport-4 (Glut4) and AMP-dependent protein kinase (AMPK) expression in both muscle and adipose tissues from obese mice. In vitro, kaempferol increased lipolysis and prevented high fatty acid-impaired glucose uptake, glycogen synthesis, AMPK activity, and Glut4 expression in skeletal muscle cells. Using another mouse model of T2D generated by HF diet feeding and low doses of streptozotocin injection, we found that kaempferol treatment significantly improved hyperglycemia, glucose tolerance, and blood insulin levels in obese diabetic mice, which are associated with the improved islet β-cell mass. These results demonstrate that kaempferol may be a naturally occurring anti-diabetic agent by improving peripheral insulin sensitivity and protecting against pancreatic β-cell dysfunction.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHana Alkhalidy, William Moore, Yanling Zhang, et al., “Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic β-Cell Mass in Middle-Aged Obese Diabetic Mice,” Journal of Diabetes Research, vol. 2015, Article ID 532984, 14 pages, 2015. doi:10.1155/2015/532984en
dc.identifier.doihttps://doi.org/10.1155/2015/532984en
dc.identifier.urihttp://hdl.handle.net/10919/78949en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2015 Hana Alkhalidy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleSmall Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic β-Cell Mass in Middle-Aged Obese Diabetic Miceen
dc.title.serialJournal of Diabetes Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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