Absorption of carnosine and methionylglycine by sheep ruminal and omasal epithelia

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dc.contributor.authorMatthews, James C.en
dc.contributor.departmentAnimal Scienceen
dc.date.accessioned2014-03-14T21:32:00Zen
dc.date.adate2010-03-17en
dc.date.available2014-03-14T21:32:00Zen
dc.date.issued1991en
dc.date.rdate2010-03-17en
dc.date.sdate2010-03-17en
dc.description.abstractCarnosine and methionylglycine (using ³⁵S-methionylglycine as a representative marker) absorption and transfer across ruminal and omasal epithelia collected from four (carnosine) and seven (methionylglycine) sheep were studied using parabiotic chambers that were repeatedly sampled over a 240-min incubation. The quantity of dipeptide absorbed or transferred was linearly (P < .01) dependent on substrate concentration. Carnosine was transferred intact across both tissues. More carnosine was absorbed (P < .02) and transferred (P < .01) by the omasal epithelia. Methionylglycine was transferred intact across both tissues, but less (P < .01) remained intact in serosal buffer after 240 min incubation with omasal epithelium than with ruminal epithelium. The amount of methionylglycine that accumulated in each tissue was similar. Methionylglycine accumulation in tissues plus transfer after 240 min was greater (P < .01) for omasal tissue. The ability of sheep ruminal and omasal epithelia to absorb and transfer carnosine and methionylglycine in parabiotic units was demonstrated. Dipeptide translocation across forestomach epithelial tissues, which has not been reported previously, may be an important route for supplying dietary amino acids to the ruminant.en
dc.description.degreeMaster of Scienceen
dc.format.extentv, 76 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-03172010-020424en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-03172010-020424/en
dc.identifier.urihttp://hdl.handle.net/10919/41689en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1991.M388.pdfen
dc.relation.isformatofOCLC# 25140506en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1991.M388en
dc.subject.lcshSheep -- Feed utilization efficiencyen
dc.titleAbsorption of carnosine and methionylglycine by sheep ruminal and omasal epitheliaen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineAnimal Scienceen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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