LTD Induction in Adult Visual Cortex: Role of Stimulus Timing and Inhibition

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dc.contributorVirginia Techen
dc.contributor.authorPerrett, Stephen P.en
dc.contributor.authorDudek, Serena M.en
dc.contributor.authorEagleman, David M.en
dc.contributor.authorMontague, P. Readen
dc.contributor.authorFriedlander, Michael J.en
dc.date.accessioned2017-09-26T13:07:52Zen
dc.date.available2017-09-26T13:07:52Zen
dc.date.issued2001-04-01en
dc.description.abstractOne Hertz stimulation of afferents for 15 min with constant interstimulus intervals (regular stimulation) can induce longterm depression (LTD) of synaptic strength in the neocortex. However, it is unknown whether natural patterns of lowfrequency afferent spike activity induce LTD. Although neurons in the neocortex can fire at overall rates as low as 1 Hz, the intervals between spikes are irregular. This irregular spike activity (and thus, presumably, irregular activation of the synapses of that neuron onto postsynaptic targets) can be approximated by stimulation with Poisson-distributed interstimulus intervals (Poisson stimulation). Therefore, if low-frequency presynaptic spike activity in the intact neocortex is sufficient to induce a generalized LTD of synaptic transmission, then Poisson stimulation, which mimics this spike activity, should induce LTD in slices. We tested this hypothesis by comparing changes in the strength of synapses onto layer 2/3 pyramidal cells induced by regular and Poisson stimulation in slices from adult visual cortex. We find that regular stimulation induces LTD of excitatory synaptic transmission as assessed by field potentials and intracellular postsynaptic potentials (PSPs) with inhibition absent. However, Poisson stimulation does not induce a net LTD of excitatory synaptic transmission. When the PSP contained an inhibitory component, neither Poisson nor regular stimulation induced LTD. We propose that the short bursts of synaptic activity that occur during a Poisson train have potentiating effects that offset the induction of LTD that is favored with regular stimulation. Thus, natural (i.e., irregular) low-frequency activity in the adult neocortex in vivo should not consistently induce LTD.en
dc.identifier.issue7en
dc.identifier.urihttp://hdl.handle.net/10919/79421en
dc.identifier.volume21en
dc.language.isoen_USen
dc.publisherSociety for Neuroscienceen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectLong-term depressionen
dc.subjectvisual cortexen
dc.subjectPoisson stimulationen
dc.subjectadult guinea pigen
dc.subjectsynpatic plasticityen
dc.subjectspike varabilityen
dc.subjectcortical reorganizationen
dc.titleLTD Induction in Adult Visual Cortex: Role of Stimulus Timing and Inhibitionen
dc.title.serialThe Journal of Neuroscienceen
dc.typeArticle - Refereeden

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