Feasibility and accuracy of 3D printed patient-specific skull contoured brain biopsy guides

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dc.contributor.authorShinn, Richard L.en
dc.contributor.authorPark, Clairen
dc.contributor.authorDeBose, Kyrilleen
dc.contributor.authorHsu, Fang-Chien
dc.contributor.authorCecere, Thomas E.en
dc.contributor.authorRossmeisl, John H. Jr.en
dc.contributor.departmentSmall Animal Clinical Sciencesen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentUniversity Librariesen
dc.date.accessioned2021-07-28T14:11:33Zen
dc.date.available2021-07-28T14:11:33Zen
dc.date.issued2021-07en
dc.description.abstractObjective Design 3D printed skull contoured brain biopsy guides (3D-SCGs) from computed tomography (CT) or T1-weighted magnetic resonance imaging (T1W MRI). Study Design Feasibility study. Sample Population Five beagle dog cadavers and two client-owned dogs with brain tumors. Methods Helical CT and T1W MRI were performed on cadavers. Planned target point was the head of the caudate nucleus. Three-dimensional-SCGs were created from CT and MRI using commercially available open-source software. Using 3D-SCGs, biopsy needles were placed into the caudate nucleus in cadavers, and CT was performed to assess needle placement accuracy, followed by histopathology. Three-dimensional-SCGs were then created and used to perform in vivo brain tumor biopsies. Results No statistical difference was found between the planned target point and needle placement. Median needle placement error for all planned target points was 2.7 mm (range: 0.86-4.5 mm). No difference in accuracy was detected between MRI and CT-designed 3D-SCGs. Median needle placement error for the CT was 2.8 mm (range: 0.86-4.5 mm), and 2.2 mm (range: 1.7-2.7 mm) for MRI. Biopsy needles were successfully placed into the target in the two dogs with brain tumors and biopsy was successfully acquired in one dog. Conclusion Three-dimensional-SCGs designed from CT or T1W MRI allowed needle placement within 4.5 mm of the intended target in all procedures, resulting in successful biopsy in one of two live dogs. Clinical Significance This feasibility study justifies further evaluation of 3D-SCGs as alternatives in facilities that do not have access to stereotactic brain biopsy.en
dc.description.notesCenter for Strategic Scientific Initiatives, National Cancer Institute, Grant/Award Numbers: P01CA207206, R01CA213423; American College of Veterinary Internal Medicine Advanced Clinical Training Fellowshipen
dc.description.sponsorshipCenter for Strategic Scientific Initiatives, National Cancer Institute [P01CA207206, R01CA213423]; American College of Veterinary Internal Medicine Advanced Clinical Training Fellowshipen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/vsu.13641en
dc.identifier.eissn1532-950Xen
dc.identifier.issn0161-3499en
dc.identifier.issue5en
dc.identifier.pmid33969898en
dc.identifier.urihttp://hdl.handle.net/10919/104425en
dc.identifier.volume50en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleFeasibility and accuracy of 3D printed patient-specific skull contoured brain biopsy guidesen
dc.title.serialVeterinary Surgeryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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