Genomic differentiation and intercontinental population structure of mosquito vectors Culex pipiens pipiens and Culex pipiens molestus

Simple item page
dc.contributor.authorYurchenko, Andrey A.en
dc.contributor.authorMasri, Reem A.en
dc.contributor.authorKhrabrova, Natalia, V.en
dc.contributor.authorSibataev, Anuarbek K.en
dc.contributor.authorFritz, Megan L.en
dc.contributor.authorSharakhova, Maria V.en
dc.contributor.departmentEntomologyen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2020-08-21T14:15:33Zen
dc.date.available2020-08-21T14:15:33Zen
dc.date.issued2020-05-05en
dc.description.abstractUnderstanding the population structure and mechanisms of taxa diversification is important for organisms responsible for the transmission of human diseases. Two vectors of West Nile virus, Culex pipiens pipiens and Cx. p. molestus, exhibit epidemiologically important behavioral and physiological differences, but the whole-genome divergence between them was unexplored. The goal of this study is to better understand the level of genomic differentiation and population structures of Cx. p. pipiens and Cx. p. molestus from different continents. We sequenced and compared the whole genomes of 40 individual mosquitoes from two locations in Eurasia and two in North America. Principal Component, ADMIXTURE, and neighbor joining analyses of the nuclear genomes identified two major intercontinental, monophyletic clusters of Cx. p. pipiens and Cx. p. molestus. The level of genomic differentiation between the subspecies was uniform along chromosomes. The ADMIXTURE analysis determined signatures of admixture in Cx. p. pipens populations but not in Cx. p. molestus populations. Comparison of mitochondrial genomes among the specimens showed a paraphyletic origin of the major haplogroups between the subspecies but a monophyletic structure between the continents. Thus, our study identified that Cx. p. molestus and Cx. p. pipiens represent different evolutionary units with monophyletic origin that have undergone incipient ecological speciation.en
dc.description.notesWe thank Igor V. Sharakhov for the productive discussion of the manuscript, Dmitri A. Karagodin for the help with formatting figures, and Janet Webster for proofreading the text. This project was supported by the Russian Science Foundation grant No 19-14-00130 to MVS. The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.en
dc.description.sponsorshipRussian Science FoundationRussian Science Foundation (RSF) [19-14-00130]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41598-020-63305-zen
dc.identifier.issn2045-2322en
dc.identifier.issue1en
dc.identifier.pmid32371903en
dc.identifier.urihttp://hdl.handle.net/10919/99801en
dc.identifier.volume10en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleGenomic differentiation and intercontinental population structure of mosquito vectors Culex pipiens pipiens and Culex pipiens molestusen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s41598-020-63305-z.pdf
Size:
3.78 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, Entomology
Scholarly Works, Fralin Life Sciences Institute