Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?
| dc.contributor.author | Cridland, Caitlin A. | en |
| dc.contributor.author | Gillaspy, Glenda E. | en |
| dc.contributor.department | Biochemistry | en |
| dc.date.accessioned | 2020-06-30T16:38:44Z | en |
| dc.date.available | 2020-06-30T16:38:44Z | en |
| dc.date.issued | 2020-06-17 | en |
| dc.date.updated | 2020-06-30T16:27:53Z | en |
| dc.description.abstract | The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP) signaling pathway. In plants and humans the pyrophosphorylated inositol molecules, inositol pyrophosphates (PP-InsPs), have been implicated in phosphate and energy sensing. PP-InsPs are synthesized from the phosphorylation of InsP<sub>6</sub>, the most abundant InsP. The plant PP-InsP synthesis pathway is similar but distinct from that of the human, which may reflect differences in how molecules such as Ins(1,4,5)P<sub>3</sub> and InsP<sub>6</sub> function in plants vs. animals. In addition, PP-InsPs can potentially interact with several major signaling proteins in plants, suggesting PP-InsPs play unique signaling roles via binding to protein partners. In this review, we will compare the biosynthesis and role of PP-InsPs in animals and plants, focusing on three central themes: InsP<sub>6</sub> synthesis pathways, synthesis and regulation of the PP-InsPs, and function of a specific protein domain called the Syg1, Pho1, Xpr1 (SPX ) domain in binding PP-InsPs and regulating inorganic phosphate (P<i>i</i>) sensing. This review will provide novel insights into the biosynthetic pathway and bioactivity of these key signaling molecules in plant and human systems. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Cridland, C.; Gillaspy, G. Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?Molecules 2020, 25, 2789. | en |
| dc.identifier.doi | https://doi.org/10.3390/molecules25122789 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/99194 | en |
| dc.language.iso | en | en |
| dc.publisher | MDPI | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | inositol phosphate | en |
| dc.subject | inositol pyrophosphate | en |
| dc.subject | inositol | en |
| dc.subject | inositol phosphate signaling | en |
| dc.subject | PPIP5K | en |
| dc.subject | ITPK | en |
| dc.title | Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants? | en |
| dc.title.serial | Molecules | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |