Browsing by Author "Furr, M. O."

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    Equine neonatal sepsis: The pathophysiology of severe inflammation and infection.
    McKenzie, H. C.; Furr, M. O. (Veterinary Learning Systems, 2001-07-01)
    Although the clinical syndrome of sepsis is a major problem in equine neonates, the pathophysiology of this condition remains incomplete. Because the term sepsis describes a broad range of disorders with different underlying causes and often different prognoses, the understanding of this process is further complicated. Continued progress is being made, how- ever, in defining the syndromes associated with sepsis and in elucidating the mechanisms in- volved in these processes. Attempts at modulating the septic process by interfering with the action of bacterial toxins or the production or activity of individual mediators have not been successful, thereby reinforcing that this is a multifactorial response. Fortunately, the complex interactions of intra- and extracellular messengers leading to clinical sepsis continue to be defined. An increased understanding of the processes involved in the septic response may aid in the identification of patients with these syndromes as well as improve the effectiveness of treatment regimens.
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    Equine Protozoal Myeloencephalitis: An Updated Consensus Statement with a Focus on Parasite Biology, Diagnosis, Treatment, and Prevention
    Reed, S. M.; Furr, M. O.; Howe, D. K.; Johnson, A. L.; MacKay, R. J.; Morrow, J. K.; Pusterla, N.; Witonsky, Sharon G. (American College of Veterinary Internal Medicine, 2016-03)
    Equine protozoal myeloencephalitis (EPM) remains an important neurologic disease of horses. There are no pathognomonic clinical signs for the disease. Affected horses can have focal or multifocal central nervous system (CNS) disease. EPM can be difficult to diagnose antemortem. It is caused by either of 2 parasites, Sarcocystis neurona and Neospora hughesi, with much less known about N. hughesi. Although risk factors such as transport stress and breed and age correlations have been identified, biologic factors such as genetic predispositions of individual animals, and parasite-specific factors such as strain differences in virulence, remain largely undetermined. This consensus statement update presents current published knowledge of the parasite biology, host immune response, disease pathogenesis, epidemiology, and risk factors. Importantly, the statement provides recommendations for EPM diagnosis, treatment, and prevention.
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    Glucocorticoid Receptor Density and Binding Affinity in Healthy Horses and Horses with Systemic Inflammatory Response Syndrome
    Hoffman, C. J.; McKenzie, H. C.; Furr, M. O.; Desrochers, A. (Wiley-Blackwell, 2015-03-01)