Virginia Tech Patents
Permanent URI for this collection
These United States Patents were originally assigned to Virginia Tech.
Browse
Browsing Virginia Tech Patents by Subject "1/1"
Now showing 1 - 19 of 19
Results Per Page
Sort Options
- Algorithm and implementation system for measuring impedance in the D-Q domain(United States Patent and Trademark Office, 2015-09-22)A controller and infrastructure for an impedance analyzer measures responses to perturbations to respective phases of a multi-phase system at an interface between stages thereof (which may be considered as a source and load in regard to each other), such as a multi-phase electrical power system, to determine a transfer function for each phase of the multi-phase system from which the impedance of each of the source and load can be calculated, particularly for assessing the stability of the multi-phase system.
- Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof(United States Patent and Trademark Office, 2015-12-15)The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
- DC-side leakage current reduction for single phase full-bridge power converter/inverter(United States Patent and Trademark Office, 2015-06-02)Leakage current through stray or parasitic capacitance (which is particularly large in devices such as photovoltaic cell arrays and which are damaged by such leakage currents) due to common mode switching noise in a full bridge single phase power converter is reduced at high frequencies by magnetically coupling the two phase legs on the AC side of the power converter and connecting mid points of the AC and DC sides of the power converter and is reduced at low frequencies by use of a feedback arrangement that modifies sinusoidal modulation of the switches of the full bridge converter to function as an active filter. The magnetic coupling for the two phase legs is designed in a simple manner to avoid saturation based on volt-second considerations.
- Flotation machine rotor(United States Patent and Trademark Office, 2016-01-19)A rotor for flotation machines or flotation cells of flotation machines includes blades that are configured to provide improved bubble flow and bubble generation performance while also reducing the power requirements for rotating the rotor to generate bubble flow within a tank of a flotation cell used to generate froth. Embodiments of the rotor may also be configured to be smaller than conventional rotor designs, which may help reduce the costs of manufacturing the rotor or flotation machines using such embodiments of the rotor.
- Flotation machine rotor(United States Patent and Trademark Office, 2016-02-23)A rotor for flotation machines or flotation cells of flotation machines includes blades that are configured to provide improved bubble flow and bubble generation performance while also reducing the power requirements for rotating the rotor to generate bubble flow within a tank of a flotation cell used to generate froth. Embodiments of the rotor may also be configured to be smaller than conventional rotor designs, which may help reduce the costs of manufacturing the rotor or flotation machines using such embodiments of the rotor.
- Infectious genomic DNA clone and serological profile of Torque teno sus virus 1 and 2(United States Patent and Trademark Office, 2016-02-02)The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of Torque teno sus virus (TTsuV). The present invention also provides methods for diagnosing TTsuV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies which indicate infections TTsuV1, TTsuV2, and individual TTsuV1 genotypes.
- Lanthionine synthetase component C-like proteins as molecular targets for preventing and treating diseases and disorders(United States Patent and Trademark Office, 2015-08-11)The present invention relates to the field of medical treatments for diseases and disorders. More specifically, the present invention relates to the use of the lanthionine synthetase component C-like (LANCL) proteins as therapeutic targets for novel classes of anti-inflammatory, immune regulatory and antidiabetic drugs. This includes but it is not limited to abscisic acid (ABA), ABA analogs, benzimidazophenyls, repurposed drugs or drug combinations, including thiazolidinediones (TZDs); naturally occurring compounds such as conjugated diene fatty acids, conjugated triene fatty acids, isoprenoids, and natural and synthetic agonists of peroxisome proliferator-activated receptors that activate this receptor through an alternative mechanism of action involving LANCL2 or other membrane proteins to treat or prevent the common inflammatory pathogenesis underlying type 2 diabetes, atherosclerosis, cancer, some inflammatory infectious diseases such as influenza and autoimmune diseases including but not limited to inflammatory bowel disease (Crohn's disease and Ulcerative colitis), rheumatoid arthritis, multiple sclerosis and type 1 diabetes and other chronic inflammatory conditions.
- Method of evaluating and ensuring stability of AC/DC power systems(United States Patent and Trademark Office, 2015-09-15)Approximating loci of eigenvalues or characteristic gains of a return ratio matrix of a model of a multi-phase power converter circuit by the loci of the d-d and q-q elements of said synchronous frame of reference applied to said model, allows determination and assessment of stability of the circuit or forbidden operational parameters of the combination of an AC power source and a power converter at an interface thereof by application of a standard Nyquist stability criterion.
- Method of synergistically enhancing the therapeutic efficacy and safety of medication through a combination therapy(United States Patent and Trademark Office, 2015-09-01)The present invention provides combinations, for treatment of subjects suffering from or at high risk of developing diseases and disorders involving expression of peroxisome proliferator-activated receptors (PPAR). The combinations include abscisic acid and one other bioactive agent, which together provide synergistic effects toward treatment or blocking of development of the disease or disorder. In exemplary embodiments, a combination of abscisic acid and a thiazolidinedione (TZD) is provided for increased insulin sensitivity and improved (i.e., reduced) obesity-induced inflammation.
- Modified live-attenuated vaccines (MLV) created by DNA shuffling against porcine reproductive and respiratory syndrome virus (PRRSV)(United States Patent and Trademark Office, 2015-09-15)The present invention provides a novel infectious cDNA clone of porcine reproductive and respiratory syndrome virus (PRRSV), particularly for PRRSV strain VR2385; an improved DNA-launched reverse genetics system for PRRSV; infectious chimeric PRRSV viruses generated through DNA shuffling; modified live-attenuated virus vaccines (MLV) using DNA shuffled chimeric viruses; chimeric viral proteins produced through shuffled chimeric viruses; PRRSV antigens and subunit vaccines based on shuffled chimeric viral proteins; and method of producing broadly protective PRRSV vaccines using DNA shuffling techniques.
- Multiple exposure with image reversal in a single photoresist layer(United States Patent and Trademark Office, 2015-08-25)Multiple patterned exposures of a single layer of image reversal resist prior to and following image reversal processing, upon development, respond to the respective exposures as either a positive or a negative resist, allowing a desired shape of a resist structure to be built up from any of a number of combinations of primitive masks. Exploiting the image reversal resist in this manner allows several types of diffraction distortion to be entirely avoided and for many sophisticated lithographic processes to he reduced in complexity by one-half or more while any desired resist structure shape can be formed form a limited number of primitive mask patterns. A regimen, which may be automated as an executable algorithm for a computer may be followed to evaluate different combinations of masks which are valid to produce a desired resist structure shape and select the optimum mask pattern combination to do so.
- Optimal trajectory control for LLC resonant converter for LED PWM dimming(United States Patent and Trademark Office, 2016-03-01)Pulse width modulation is provided for controlling a resonant power converter, particularly for dimming of light emitting diode arrays without loss of efficiency. Dynamic oscillation due to the beginning of a pulse width modulated pulse burst is limited by shortening of the first and/or last pulse of a pulse bust such that the first pulse of a subsequent pulse burst close to or to connect with a full load steady-state voltage/current trajectory of the power converter. Pulse shortening made be made substantially exact to virtually eliminate dynamic oscillation but substantial reduction in dynamic oscillation is provided if inexact or even performed randomly.
- Optimal trajectory control for LLC resonant converter for soft start-up(United States Patent and Trademark Office, 2016-04-19)By setting switching instants of a switching circuit of a resonant power converter based on current in a resonant circuit reaching a current limit of a current limitation band, soft start-up of the power converter can be achieved to avoid or limit electrical stress with full control over a trade-off between time required to settle to a full load steady-state mode of operation and the amount of electrical stress permitted while soft start up switching frequency is automatically optimized.
- Pool cleaner with laser range finder system and method(United States Patent and Trademark Office, 2015-07-21)Embodiments of the invention provide a pool cleaner control system including a laser range finder with a first laser line generator, a second laser line generator, and a camera. The first laser line generator and the second laser line generator are positioned to emit parallel laser lines and the camera is positioned to capture an image of the laser lines projected on an object. The control system also includes a controller in communication with the laser range finder and configured to control operation of the laser line generators to emit the laser lines and to control the camera to capture the image. The controller is also configured to receive the image from the camera, calculate a pixel distance between the laser lines in the image, and calculate the physical distance between the camera and the object based on the pixel distance.
- Porcine torque teno virus vaccines and diagnosis(United States Patent and Trademark Office, 2016-01-05)The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.
- System and method for estimating a treatment volume for administering electrical-energy based therapies(United States Patent and Trademark Office, 2016-03-15)The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.
- Treatment planning for electroporation-based therapies(United States Patent and Trademark Office, 2015-12-01)The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
- Two-stage single phase bi-directional PWM power converter with DC link capacitor reduction(United States Patent and Trademark Office, 2015-06-30)DC link capacitance in a bi-directional AC/DC power converter using a full-bridge or H-bridge switching circuit can be greatly reduced and the power density of the power converter correspondingly increased by inclusion of a bi-directional synchronous rectifier (SR) DC/DC converter as a second stage of the power converter and controlling the second stage with a control loop having a transfer function common to both buck and boost modes of operation of the bi-directional SR DC/DC converter and a resonant transfer function to increase gain at the ripple voltage frequency (twice the AC line frequency) to control the duty cycle of the switches of the bi-directional SR DC/DC stage and controlling the duty cycle of the switches of the full-bridge or H-bridge switching circuit using a control loop including a notch filter at the ripple voltage frequency.
- Using power fingerprinting (PFP) to monitor the integrity and enhance security of computer based systems(United States Patent and Trademark Office, 2016-02-16)Procedures are described for enhancing target system execution integrity determined by power fingerprinting (PFP): by integrating PFP into the detection phase of comprehensive defense-in-depth security; by deploying a network of PFP enabled nodes executing untrusted devices with predefined inputs forcing a specific state sequence and specific software execution; by embedding module identification information into synchronization signaling; by combining signals from different board elements; by using malware signatures to enhance PFP performance; by automatic characterization and signature extraction; by providing secure signature updates; by protecting against side-channel attacks; performing real-time integrity assessment in embedded platform by monitoring their dynamic power consumption and comparing it against signatures from trusted code, including pre-characterizing power consumption of the platform by concentrating on trace sections carrying the most information about the internal execution status; by using PFP from sequence of bit transitions to detect deviations from authorized execution of software in a digital processor.