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dc.contributor.authorWang, Linglingen
dc.contributor.authorHe, Wenxiaoen
dc.contributor.authorQu, Huihuaen
dc.contributor.authorJia, Changkaien
dc.contributor.authorWang, Yaoen
dc.contributor.authorWang, Yiqiangen
dc.contributor.authorLiu, Dongminen
dc.date.accessioned2021-04-26T13:58:31Zen
dc.date.available2021-04-26T13:58:31Zen
dc.date.issued2014-11-21en
dc.identifier.urihttp://hdl.handle.net/10919/103123en
dc.description.abstractNeovascularization is often involved in many diseases and there is no effective treatment for this pathological process. In searching for potential therapies for neovascularization, we screened nineteen pre-selected small molecules isolated from herbal extracts for their possible anti-angiogenic effect in vitro and in vivo. We found that isoliquiritigenin, a chalconoid compound isolated from Chinese herb medicine licorice, potently inhibited vascular endothelial cell (EC) proliferation, migration, tube -like structure formation ex vivo. Western blot analysis shows that exposure of ECs to isoliquiritigenin inhibited extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation. In Matrigel plug assay, isoliquiritigenin effectively blocked fibroblast growth factor-induced in vivo angiogenesis in mice. Consistently, topical application of isoliquiritigenin significantly inhibited chemical injury-induced corneal neovascularization in mice. Collectively, these results suggest that isoliquiritigenin may be a low-cost and effective natural agent to treat angiogenesis-dependent diseases.en
dc.language.isoen_USen
dc.publisherHilarisen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectIsoliquiritigeninen
dc.subjectVascular endothelial cellen
dc.subjectProliferationen
dc.subjectMigrationen
dc.subjectAngiogenesisen
dc.subjectNeovascularizationen
dc.titlePhytochemical Isoliquiritigenin Inhibits Angiogenesis Ex Vivo and Corneal Neovascularization in Miceen
dc.typeArticle - Refereeden
dc.title.serialAlternative & Integrative Medicineen
dc.identifier.doihttp://dx.doi.org/10.4172/2327-5162.1000176en
dc.identifier.volume3en
dc.identifier.issue4en


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Attribution 4.0 International
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