Now showing items 1-10 of 35
Identifying protein interaction subnetworks by a bagging Markov random field-based method
(Nucleic Acids Research, 2013)
Identification of differentially expressed subnetworks from protein-protein interaction (PPI) networks has become increasingly important to our global understanding of the molecular mechanisms that drive cancer. Several ...
ChIP-BIT: Bayesian inference of target genes using a novel joint probabilistic model of ChIP-seq profiles
Chromatin immunoprecipitation with massively parallel DNA sequencing (ChIP-seq) has greatly improved the reliability with which transcription factor binding sites (TFBSs) can be identified from genome-wide profiling studies. ...
Unsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamics
With the existence of biologically distinctive malignant cells originated within the same tumor, intratumor functional heterogeneity is present in many cancers and is often manifested by the intermingled vascular compartments ...
Genome-wide identification of significant aberrations in cancer genome
Background Somatic Copy Number Alterations (CNAs) in human genomes are present in almost all human cancers. Systematic efforts to characterize such structural variants must effectively distinguish significant consensus ...
SIMAT: GC-SIM-MS data analysis tool
Background Gas chromatography coupled with mass spectrometry (GC-MS) is one of the technologies widely used for qualitative and quantitative analysis of small molecules. In particular, GC coupled to single quadrupole MS ...
Modeling and Reconstruction of Mixed Functional and Molecular Patterns
Functional medical imaging promises powerful tools for thevisualization and elucidation of important disease-causingbiological processes in living tissue. Recent research aims todissect the distribution or expression of ...
Gene Selection for Multiclass Prediction by Weighted Fisher Criterion
Gene expression profiling has been widely used to study molecular signatures of many diseases and to develop molecular diagnostics for disease prediction. Gene selection, as an important step for improved diagnostics, ...
Paternal malnutrition programs breast cancer risk and tumor metabolism in offspring
Abstract Background While many studies have shown that maternal factors in pregnancy affect the cancer risk for offspring, few studies have investigated the impact of paternal ...