Research articles, presentations, and other scholarship

Recent Submissions

  • The Komodo dragon (Varanus komodoensis) genome and identification of innate immunity genes and clusters 

    van Hoek, Monique L.; Prickett, M. D.; Settlage, Robert E.; Kang, Lin; Michalak, Pawel; Vliet, Kent A.; Bishop, Barney M. (2019-08-30)
    Abstract Background We report the sequencing, assembly and analysis of the genome of the Komodo dragon (Varanus komodoensis), the largest extant lizard, with a focus on ...
  • Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel 

    Kang, Lin; Rashkovetsky, Eugenia; Michalak, Katarzyna; Garner, Harold R.; Mahaney, James E.; Rzigalinski, Beverly A.; Korol, Abraham; Nevo, Eviatar; Michalak, Pawel (2019-06-11)
    Biodiversity refugia formed by unique features of the Mediterranean arid landscape, such as the dramatic ecological contrast of "Evolution Canyon," provide a natural laboratory in which local adaptations to divergent ...
  • Campylobacter jejuni - An emerging foodborne pathogen 

    Altekruse, Sean Fitzgerald; Stern, NJ; Fields, PI; Swerdlow, DL (1999-01)
    Campylobacter jejuni is the most commonly reported bacterial cause of foodborne infection in the United States. Adding to the human and economic costs are chronic sequelae associated with C. jejuni infection-Guillain-Barre ...
  • Evaluation of Risk of Zoonotic Pathogen Transmission in a University-Based Animal Assisted Intervention (AAI) Program 

    Boyle, Sara F.; Corrigan, Virginia K.; Buechner-Maxwell, Virginia; Pierce, Bess J. (Frontiers, 2019-06-04)
    Introduction: Previous studies have shown that apparently healthy animals participating in Animal-Assisted Interventions (AAI) have the potential to asymptomatically carry and even transmit zoonotic pathogens to people, ...
  • Mapping the potential use of endectocide-treated cattle to reduce malaria transmission 

    Imbahale, Susan S.; Montana Lopez, Julia; Brew, Joe; Paaijmansz, Krijn; Rist, Cassidy; Chaccour, Carlos (Springer Nature, 2019-04-09)
    Treating cattle with endectocide is a longstanding veterinary practice to reduce the load of endo and ectoparasites, but has the potential to be added to the malaria control and elimination toolbox, as it also kills malaria ...
  • Pregnancy and lactation interfere with the response of autoimmunity to modulation of gut microbiota 

    Mu, Qinghui; Cabana-Puig, Xavier; Mao, Jiangdi; Swartwout, Brianna; Abdelhamid, Leila; Cecere, Thomas E.; Wang, Haifeng; Reilly, Christopher M.; Luo, Xin M. (2019-07-16)
    Abstract Background Dysbiosis of gut microbiota exists in the pathogenesis of many autoimmune diseases, including systemic lupus erythematosus (lupus). Lupus patients who ...
  • Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review 

    Tham, Heng L.; Linder, Keith E.; Olivry, Thierry (2019-07-19)
    Abstract Autoimmune dermatoses targeting melanocytes have gained attention in human medicine due to their progressive nature and the social impact suffered by affected individuals. In veterinary medicine, ...
  • Reflective Roofing Research: Influence of Roof Color on Adjacent Air and Surface Temperatures 

    Grant, E. J.; Black, K. A.; Werre, S. (2017-03-19)
    An experimental study was conducted to answer questions about the thermal effects of roof reflectivity on the neighbouring built environment. Temperatures were recorded at the surface of black ethylene propylene diene ...
  • Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs 

    Witzel-Rollins, Angela; Murphy, Maryanne; Becvarova, Iveta; Werre, Stephen R.; Cadiergues, Marie-Christine; Meyer, Hein (2019-06-28)
    Abstract Background Canine atopic dermatitis (AD) is a common skin disease. The goal of this study was to evaluate food designed to improve skin barrier function and lower ...
  • Characterization of Outer Membrane Vesicles from Brucella melitensis and Protection Induced in Mice 

    Avila-Calderon, Eric Daniel; Lopez-Merino, Ahide; Jain, Neeta; Peralta, Humberto; Lopez-Villegas, Edgar Oliver; Sriranganathan, Nammalwar; Boyle, Stephen M.; Witonsky, Sharon; Contreras-Rodriguez, Araceli (Hindawi Publishing Corp, 2011-12-29)
    The outer membrane vesicles (OMVs) from smooth B. melitensis 16 M and a derived rough mutant, VTRM1 strain, were purified and characterized with respect to protein content and induction of immune responses in mice. Proteomic ...
  • Comparative Genomics of Early-Diverging Brucella Strains Reveals a Novel Lipopolysaccharide Biosynthesis Pathway 

    Wattam, Alice R.; Inzana, Thomas J.; Williams, Kelly P.; Mane, Shrinivasrao P.; Shukla, Maulik; Almeida, Nalvo F.; Dickerman, Allan W.; Mason, Steven; Moriyon, Ignacio; O'Callaghan, David; Whatmore, Adrian M.; Sobral, Bruno W.; Tiller, Rebekah V.; Hoffmaster, Alex R.; Frace, Michael A.; De Castro, Cristina; Molinaro, Antonio; Boyle, Stephen M.; De, Barun K.; Setubal, Joao C. (American Society for Microbiology, 2012-11)
    Brucella species are Gram-negative bacteria that infect mammals. Recently, two unusual strains (Brucella inopinata BO1T and B. inopinata-like BO2) have been isolated from human patients, and their similarity to some atypical ...
  • A versatile computational pipeline for bacterial genome annotation improvement and comparative analysis, with Brucella as a use case 

    Yu, G. X.; Snyder, E. E.; Boyle, S. M.; Crasta, O. R.; Czar, M.; Mane, S. P.; Purkayastha, A.; Sobral, B.; Setubal, J. C. (2007-06)
    We present a bacterial genome computational analysis pipeline, called GenVar. The pipeline, based on the program GeneWise, is designed to analyze an annotated genome and automatically identify missed gene calls and sequence ...
  • PATRIC: The VBI PathoSystems Resource Integration Center 

    Snyder, E. E.; Kampanya, N.; Lu, J.; Nordberg, E. K.; Karur, H. R.; Shukla, M.; Soneja, J.; Tian, Y.; Xue, T.; Yoo, H.; Zhang, F.; Dharmanolla, C.; Dongre, N. V.; Gillespie, J. J.; Hamelius, J.; Hance, M.; Huntington, K. I.; Jukneliene, D.; Koziski, J.; Mackasmiel, L.; Mane, S. P.; Nguyen, V.; Purkayastha, A.; Shallom, J.; Yu, G.; Guo, Y.; Gabbard, J.; Hix, D.; Azad, A. F.; Baker, S. C.; Boyle, S. M.; Khudyakov, Y.; Meng, X. J.; Rupprecht, C.; Vinje, J.; Crasta, O. R.; Czar, M. J.; Dickerman, A.; Eckart, J. D.; Kenyon, R.; Will, R.; Setubal, J. C.; Sobral, B. W. S. (2007-01)
    The PathoSystems Resource Integration Center (PATRIC) is one of eight Bioinformatics Resource Centers (BRCs) funded by the National Institute of Allergy and Infection Diseases (NIAID) to create a data and analysis resource ...
  • CAGm: A repository of germline microsatellite variations in the 1000 genomes project 

    Kinney, N.; Titus-Glover, K.; Wren, J.D.; Varghese, R.T.; Michalak, P.; Liao, H.; Anandakrishnan, R.; Pulenthiran, A.; Kang, L.; Garner, Harold R. (Oxford University Press, 2019-01-08)
    The human genome harbors an abundance of repetitive DNA; however, its function continues to be debated. Microsatellites-a class of short tandem repeat-are established as an important source of genetic variation. Array ...
  • Infectious genomic DNA clone and serological profile of torque teno sus virus 1 and 2 

    Virginia Tech Intellectual Properties, Inc.; Meng, Xiang-Jin; Huang, Yaowei (United States Patent and Trademark Office, 2018-09-04)
    The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of Torque teno sus virus (TTsuV). The present invention also ...
  • Porcine torque teno virus vaccines and diagnosis 

    Virginia Tech Intellectual Properties, Inc.; Meng, Xiang-Jin; Huang, Yaowei (United States Patent and Trademark Office, 2018-02-20)
    The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present ...
  • Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof 

    Virginia Tech Intellectual Properties, Inc.; Iowa State University Reserach Foundation, Inc.; Meng, Xiang-Jin; Halbur, Patrick G.; Fenaux, Martijn (United States Patent and Trademark Office, 2018-02-13)
    The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome ...
  • Live attenuated chimeric porcine circovirus vaccine 

    Virginia Tech Intellectual Properties, Inc.; Meng, Xiang-Jin; Beach, Nathan M.; Ramamoorthy, Sheela (United States Patent and Trademark Office, 2018-01-02)
    The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus ...
  • Live attenuated chimeric porcine circovirus vaccine 

    Virginia Tech Intellectual Properties, Inc.; Meng, Xiang-Jin; Beach, Nathan M.; Ramamoorthy, Sheela (United States Patent and Trademark Office, 2017-04-04)
    The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus ...
  • Live attenuated chimeric porcine circovirus vaccine 

    Virginia Tech Intellectual Properties, Inc.; Meng, Xiang-Jin; Beach, Nathan M.; Ramamoorthy, Sheela (United States Patent and Trademark Office, 2017-03-07)
    The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus ...

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