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Now showing items 1-20 of 100

    • A 7-week-old male Golden Retriever with extreme leukocytosis: A case report 

      Bingham, Emily; Conner, Bobbi; Stern, Jere; Vitalo, Amber; Schaer, Michael (Wiley, 2020-09-27)
      Although neoplasia should be a top concern for extreme leukocytosis in dogs, infectious causes must also be considered to avoid delays in treatment or undue recommendations for humane euthanasia. Blood film review is of ...
    • A History of the Development of Brucella Vaccines 

      Avila-Calderon, Eric Daniel; Lopez-Merino, Ahidé; Sriranganathan, Nammalwar; Boyle, Stephen M.; Contreras-Rodriguez, Araceli (Hindawi Publishing Corporation, 2013)
      Brucellosis is a worldwide zoonosis affecting animal and human health. In the last several decades, much research has been performed to develop safer Brucella vaccines to control the disease mainly in animals. Till now, ...
    • Aligned nanofiber topography directs the tenogenic differentiation of mesenchymal stem cells 

      Popielarczyk, Tracee L.; Nain, Amrinder S.; Barrett, Jennifer G. (MDPI, 2017-01-06)
      Tendon is commonly injured, heals slowly and poorly, and often suffers re-injury after healing. This is due to failure of tenocytes to effectively remodel tendon after injury to recapitulate normal architecture, resulting ...
    • Antibiotics ameliorate lupus-like symptoms in mice 

      Mu, Qinghui; Tavella, Vincent J.; Kirby, Jay L.; Cecere, Thomas E.; Chung, Matthias; Lee, Jiyoung; Li, Song; Ahmed, S. Ansar; Eden, Kristin; Allen, Irving C. (Nature, 2017-10-20)
      Gut microbiota and the immune system interact to maintain tissue homeostasis, but whether this interaction is involved in the pathogenesis of systemic lupus erythematosus (SLE) is unclear. Here we report that oral antibiotics ...
    • Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review 

      Tham, Heng L.; Linder, Keith E.; Olivry, Thierry (2019-07-19)
      Abstract Autoimmune dermatoses targeting melanocytes have gained attention in human medicine due to their progressive nature and the social impact suffered by affected individuals. In veterinary medicine, ...
    • Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth 

      Sano, Michael B.; Arena, Christopher B.; Bittleman, Katelyn R.; DeWitt, Matthew R.; Cho, Hyung J.; Szot, Christopher S.; Saur, Dieter; Cissell, James M.; Robertson, John; Lee, Yong Woo; Davalos, Rafael V. (Nature Publishing Group, 2015-10-13)
      Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility in the treatment of unresectable tumors where thermal ablation techniques are contraindicated. IRE uses ultra-short duration, ...
    • CAGm: A repository of germline microsatellite variations in the 1000 genomes project 

      Kinney, N.; Titus-Glover, K.; Wren, J.D.; Varghese, R.T.; Michalak, P.; Liao, H.; Anandakrishnan, R.; Pulenthiran, A.; Kang, L.; Garner, Harold R. (Oxford University Press, 2019-01-08)
      The human genome harbors an abundance of repetitive DNA; however, its function continues to be debated. Microsatellites-a class of short tandem repeat-are established as an important source of genetic variation. Array ...
    • Campylobacter jejuni - An emerging foodborne pathogen 

      Altekruse, Sean Fitzgerald; Stern, N. J.; Fields, P. I.; Swerdlow, D. L. (1999-01)
      Campylobacter jejuni is the most commonly reported bacterial cause of foodborne infection in the United States. Adding to the human and economic costs are chronic sequelae associated with C. jejuni infection-Guillain-Barre ...
    • Cardiovascular and respiratory effects of lumbosacral epidural bupivacaine in isoflurane-anesthetized dogs: The effects of two volumes of 0.25% solution 

      Dias, Raquel Sartori Gonçalves; Soares, João Henrique Neves; Castro, Douglas dos Santos e; Gress, Maria Alice Kuster de Albuquerque; Machado, Marcela Lemos; Otero, Pablo E.; Ascoli, Fabio Otero (PLOS, 2018-04-18)
      The purpose of this study was to compare cardiovascular and respiratory effects of two volumes of bupivacaine 0.25% (0.2 mL kg-1—treatment BUP02—and 0.4 mL kg-1 –treatment BUP04) administered epidurally at the lumbosacral ...
    • Cell-Based Therapies for Joint Disease in Veterinary Medicine: What We Have Learned and What We Need to Know 

      Bogers, Sophie Helen (Frontiers, 2018-04-16)
      Biological cell-based therapies for the treatment of joint disease in veterinary patients include autologous-conditioned serum, platelet-rich plasma, and expanded or nonexpanded mesenchymal stem cell products. This narrative ...
    • Characterization of Outer Membrane Vesicles from Brucella melitensis and Protection Induced in Mice 

      Avila-Calderon, Eric Daniel; Lopez-Merino, Ahide; Jain, Neeta; Peralta, Humberto; Lopez-Villegas, Edgar Oliver; Sriranganathan, Nammalwar; Boyle, Stephen M.; Witonsky, Sharon; Contreras-Rodriguez, Araceli (Hindawi Publishing Corp, 2011-12-29)
      The outer membrane vesicles (OMVs) from smooth B. melitensis 16 M and a derived rough mutant, VTRM1 strain, were purified and characterized with respect to protein content and induction of immune responses in mice. Proteomic ...
    • Chemokines and Chemokine Receptors in the Development of Lupus Nephritis 

      Liao, Xiaofeng; Pirapakaran, Tharshikha; Luo, Xin M. (Hindawi, 2016-06-14)
      Lupus nephritis (LN) is a major cause of morbidity and mortality in the patients with systemic lupus erythematosus (SLE), an autoimmune disease with damage to multiple organs. Leukocyte recruitment into the inflamed kidney ...
    • Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof 

      Virginia Tech Intellectual Properties, Inc.; Iowa State University Reserach Foundation, Inc.; Meng, Xiang-Jin; Halbur, Patrick G.; Fenaux, Martijn (United States Patent and Trademark Office, 2018-02-13)
      The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome ...
    • Comparative Genomics of Early-Diverging Brucella Strains Reveals a Novel Lipopolysaccharide Biosynthesis Pathway 

      Wattam, Alice R.; Inzana, Thomas J.; Williams, Kelly P.; Mane, Shrinivasrao P.; Shukla, Maulik; Almeida, Nalvo F.; Dickerman, Allan W.; Mason, Steven; Moriyon, Ignacio; O'Callaghan, David; Whatmore, Adrian M.; Sobral, Bruno; Tiller, Rebekah V.; Hoffmaster, Alex R.; Frace, Michael A.; De Castro, Cristina; Molinaro, Antonio; Boyle, Stephen M.; De, Barun K.; Setubal, Joao C. (American Society for Microbiology, 2012-11)
      Brucella species are Gram-negative bacteria that infect mammals. Recently, two unusual strains (Brucella inopinata BO1T and B. inopinata-like BO2) have been isolated from human patients, and their similarity to some atypical ...
    • A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T 

      Siddaramappa, Shivakumara; Challacombe, Jean F.; DeCastro, Rosana E.; Pfeiffer, Friedhelm; Sastre, Diego E.; Giménez, María I.; Paggi, Roberto A.; Detter, John C.; Davenport, Karen W.; Goodwin, Lynne A.; Kyrpides, Nikos; Tapia, Roxanne; Pitluck, Samuel; Lucas, Susan; Woyke, Tanja; Maupin-Furlow, Julie A. (2012-05-04)
      Background Natrialba magadii is an aerobic chemoorganotrophic member of the Euryarchaeota and is a dual extremophile requiring alkaline conditions and hypersalinity for optimal growth. The genome sequence of Nab. magadii ...
    • Comparison of the Effects of Interleukin-1 on Equine Articular Cartilage Explants and Cocultures of Osteochondral and Synovial Explants 

      Byron, Christopher R.; Trahan, Richard A. (Frontiers, 2017-09-20)
      Osteoarthritis (OA) is a ubiquitous disease affecting many horses. The disease causes chronic pain and decreased performance for patients and great cost to owners for diagnosis and treatment. The most common treatments ...
    • Computed Tomographic Features in a Case of Bilateral Neoplastic Cryptorchidism with Suspected Torsion in a Dog. 

      Stokowski, Scott; Ruth, Jeffrey; Lanz, Otto I.; Ziglioli, Vincent (2016)
      An 11-year-old male German Shepherd dog presented for inappetence and weight loss. Physical examination and initial bloodwork revealed palpable abdominal masses, mild non-regenerative anemia, and thrombocytopenia. Survey ...
    • Computed Tomography and Magnetic Resonance Imaging Are Equivalent in Mensuration and Similarly Inaccurate in Grade and Type Predictability of Canine Intracranial Gliomas 

      Stadler, Krystina L.; Ruth, Jeffrey D.; Pancotto, Theresa E.; Werre, Stephen R.; Rossmeisl, John H. (Frontiers, 2017-09-25)
      While magnetic resonance imaging (MRI) is the gold-standard imaging modality for diagnosis of intracranial neoplasia, computed tomography (CT) remains commonly used for diagnosis and therapeutic planning in veterinary ...
    • Control of lupus nephritis by changes of gut microbiota 

      Mu, Qinghui; Zhang, Husen; Liao, Xiaofeng; Lin, Kaisen; Liu, Hualan; Edwards, Michael R.; Ahmed, S. Ansar; Yuan, Ruoxi; Li, Liwu; Cecere, Thomas E.; Branson, David B.; Kirby, Jay L.; Goswami, Poorna; Leeth, Caroline M.; Read, Kaitlin A.; Oestreich, Kenneth J.; Vieson, Miranda D.; Reilly, Christopher M.; Luo, Xin M. (2017-07-11)
      Background: Systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure. Immunosuppressants used in treatment put patients at a higher risk of infections. New ...
    • Duration of seminal Zika viral RNA shedding in immunocompetent mice inoculated with Asian and African genotype viruses 

      McDonald, Erin M.; Duggal, Nisha K.; Delorey, Mark J.; Oksanish, James; Ritter, Jana M.; Brault, Aaron C. (Elsevier, 2019-06-20)
      Prior to the emergence of Asian genotype Zika virus (ZIKV) in the Western hemisphere, sexual transmission in humans was documented. Sexual transmission by African genotype ZIKVs has not been assessed in laboratory animal ...