Now showing items 1-20 of 61

    • van der Waals and hygroscopic forces of adhesion generated by spider capture threads 

      Hawthorn, A. C.; Opell, B. D. (Company of Biologists Ltd., 2003-11)
      Cribellar thread is the most primitive type of sticky prey capture thread found in aerial spider webs. Its outer surface is formed of thousands of fine fibrils that issue from a cribellum spinning field. The fibrils of ...
    • Effects of antemortem ingestion of ethanol on insect successional patterns and development of Phormia regina (Diptera : Calliphoridae) 

      Tabor, Kimberly L.; Fell, Richard D.; Brewster, Carlyle C.; Pelzer, Kevin; Behonick, George S. (Oxford University Press, 2005-05-01)
      The effects of antemortem ingestion of ethanol by domestic pigs, Sus scrofa L., on postmortem insect successional patterns and the development of Phormia regina (Meigen) were studied during summer 2003 in Blacksburg, VA. ...
    • Molecular targets for rapid identification of Brucellaspp 

      Ratushna, Vladyslava G.; Sturgill, David M.; Ramamoorthy, Sheela; Reichow, Sherry A.; He, Yongqun; Lathigra, Raju; Sriranganathan, Nammalwar; Halling, Shirley M.; Boyle, Stephen M.; Gibas, Cynthia J. (2006-02-22)
      Background Brucella is an intracellular pathogen capable of infecting animals and humans. There are six recognized species of Brucella that differ in their host preference. The genomes of the three Brucella species have ...
    • PATRIC: The VBI PathoSystems Resource Integration Center 

      Snyder, E. E.; Kampanya, N.; Lu, J.; Nordberg, E. K.; Karur, H. R.; Shukla, M.; Soneja, J.; Tian, Y.; Xue, T.; Yoo, H.; Zhang, F.; Dharmanolla, C.; Dongre, N. V.; Gillespie, J. J.; Hamelius, J.; Hance, M.; Huntington, K. I.; Jukneliene, D.; Koziski, J.; Mackasmiel, L.; Mane, S. P.; Nguyen, V.; Purkayastha, A.; Shallom, J.; Yu, G.; Guo, Y.; Gabbard, J.; Hix, D.; Azad, A. F.; Baker, S. C.; Boyle, S. M.; Khudyakov, Y.; Meng, X. J.; Rupprecht, C.; Vinje, J.; Crasta, O. R.; Czar, M. J.; Dickerman, A.; Eckart, J. D.; Kenyon, R.; Will, R.; Setubal, J. C.; Sobral, B. W. S. (2007-01)
      The PathoSystems Resource Integration Center (PATRIC) is one of eight Bioinformatics Resource Centers (BRCs) funded by the National Institute of Allergy and Infection Diseases (NIAID) to create a data and analysis resource ...
    • A versatile computational pipeline for bacterial genome annotation improvement and comparative analysis, with Brucella as a use case 

      Yu, G. X.; Snyder, E. E.; Boyle, S. M.; Crasta, O. R.; Czar, M.; Mane, S. P.; Purkayastha, A.; Sobral, B.; Setubal, J. C. (2007-06)
      We present a bacterial genome computational analysis pipeline, called GenVar. The pipeline, based on the program GeneWise, is designed to analyze an annotated genome and automatically identify missed gene calls and sequence ...
    • Enzymatic, immunological and phylogenetic characterization of Brucella suis urease 

      Contreras-Rodriguez, Araceli; Quiroz-Limon, Jose; Martins, Ana M.; Peralta, Humberto; Avila-Calderon, Eric; Sriranganathan, Nammalwar; Boyle, Stephen M.; Lopez-Merino, Ahide (2008-07-19)
      Background The sequenced genomes of the Brucella spp. have two urease operons, ure-1 and ure-2, but there is evidence that only one is responsible for encoding an active urease. The present work describes the purification ...
    • Incorporation of membrane-bound, mammalian-derived immunomodulatory proteins into influenza whole virus vaccines boosts immunogenicity and protection against lethal challenge 

      Herbert, Andrew S.; Heffron, Lynn; Sundick, Roy; Roberts, Paul C. (2009-04-24)
      Background Influenza epidemics continue to cause morbidity and mortality within the human population despite widespread vaccination efforts. This, along with the ominous threat of an avian influenza pandemic (H5N1), ...
    • Identification, Characterization and Immunogenicity of an O-Antigen Capsular Polysaccharide of Francisella tularensis 

      Apicella, Michael A.; Post, Deborah M. B.; Fowler, Andrew C.; Jones, Bradley D.; Rasmussen, Jed A.; Hunt, Jason R.; Imagawa, Sayaka; Choudhury, Biswa; Inzana, Thomas J.; Maier, Tamara M.; Frank, Dara W.; Zahrt, Thomas C.; Chaloner, Kathryn; Jennings, Michael P.; McLendon, Molly K.; Gibson, Bradford W. (PLOS, 2010-07-06)
      Capsular polysaccharides are important factors in bacterial pathogenesis and have been the target of a number of successful vaccines. Francisella tularensis has been considered to express a capsular antigen but none has ...
    • Tocopherol induced angiogenesis in placental vascular network in late pregnant ewes 

      Kasimanickam, Ramanathan K; Kasimanickam, Vanmathy R; Rodriguez, Jacobo S; Pelzer, Kevin D; Sponenberg, Philip D; Thatcher, Craig D (2010-07-12)
      Background Tocopherols have biphasic, proangiogenic and antiangiogenic therapeutic effects. The objective of this clinical trial was to clarify tocopherol's placental angiogenic potential in late pregnant ewes following ...
    • Non-Thermal Irreversible Electroporation (N-TIRE) and Adjuvant Fractionated Radiotherapeutic Multimodal Therapy for Intracranial Malignant Glioma in a Canine Patient 

      Garcia, P. A.; Pancotto, T.; Rossmeisl, John H. Jr.; Henao-Guerrero, N.; Gustafson, N. R.; Daniel, G. B.; Robertson, J. L.; Ellis, T. L.; Davalos, Rafael V. (Adenine Press, 2011-02-01)
      Non-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE ...
    • Horizontal gene transfer in Histophilus somni and its role in the evolution of pathogenic strain 2336, as determined by comparative genomic analyses 

      Siddaramappa, Shivakumara; Challacombe, Jean F; Duncan, Alison J; Gillaspy, Allison F; Carson, Matthew; Gipson, Jenny; Orvis, Joshua; Zaitshik, Jeremy; Barnes, Gentry; Bruce, David; Chertkov, Olga; Detter, J Chris; Han, Cliff S; Tapia, Roxanne; Thompson, Linda S; Dyer, David W; Inzana, Thomas J. (2011-11-23)
      Background Pneumonia and myocarditis are the most commonly reported diseases due to Histophilus somni, an opportunistic pathogen of the reproductive and respiratory tracts of cattle. Thus far only a few genes involved in ...
    • Molecular epidemiology of hepatitis E virus infections in Shanghai, China 

      Zhu, Yumin; Si, Fusheng; Cao, Dianjun; Yu, Xiaoming; Yu, Ruisong; Dong, Shijuan; Huang, Fenfen; Zhang, Yuanshu; Li, Zhen (2011-12-15)
      Background Hepatitis E virus (HEV) causes acute or fulminant hepatitis in humans and is an important public health concern in many developing countries. China has a high incidence of HEV epidemics, with at least three ...
    • Characterization of Outer Membrane Vesicles from Brucella melitensis and Protection Induced in Mice 

      Avila-Calderon, Eric Daniel; Lopez-Merino, Ahide; Jain, Neeta; Peralta, Humberto; Lopez-Villegas, Edgar Oliver; Sriranganathan, Nammalwar; Boyle, Stephen M.; Witonsky, Sharon; Contreras-Rodriguez, Araceli (Hindawi Publishing Corp, 2011-12-29)
      The outer membrane vesicles (OMVs) from smooth B. melitensis 16 M and a derived rough mutant, VTRM1 strain, were purified and characterized with respect to protein content and induction of immune responses in mice. Proteomic ...
    • Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it? 

      Cecere, Thomas E.; Todd, S. Michelle; LeRoith, Tanya (MDPI, 2012-05-01)
      Regulatory T cells (Tregs) are a subset of T cells that are responsible for maintaining peripheral immune tolerance and homeostasis. The hallmark of Tregs is the expression of the forkhead box P3 ...
    • Risk Factors of Porcine Cysticercosis in the Eastern Cape Province, South Africa 

      Krecek, Rosina Claudia; Mohammed, Hamish; Michael, Lynne Margaret; Schantz, Peter Mullineaux; Ntanjana, Lulama; Morey, Liesl; Werre, Stephen Rakem; Willingham, Arve Lee, III (PLOS, 2012-05-24)
      There is a high prevalence of Taenia solium taeniosis/cysticercosis in humans and pigs in the Eastern Cape Province (ECP) of South Africa. The objective of this study was to identify risk factors of porcine cysticercosis ...
    • The role of lipooligosaccharide phosphorylcholine in colonization and pathogenesis of Histophilus somni in cattle 

      Elswaifi, Shaadi F.; Scarratt, William K.; Inzana, Thomas J. (Biomed Central Ltd, 2012-06-07)
      Histophilus somni is a Gram-negative bacterium and member of the Pasteurellaceae that is responsible for respiratory disease and other systemic infections in cattle. One of the bacterium’s virulence factors is antigenic ...
    • Recombination Activating Gene-2 Regulates CpG-Mediated Interferon-α Production in Mouse Bone Marrow-Derived Plasmacytoid Dendritic Cells 

      Luo, Xin; Lei, Margarida (PLOS, 2012-10-24)
      Using mice that lack recombination activating gene-2 (Rag2), we have found that bone marrow-derived plasmacytoid dendritic cells (pDCs) as main producers of interferon-α (IFNα) require Rag2 for normal development. This is ...
    • Comparative Genomics of Early-Diverging Brucella Strains Reveals a Novel Lipopolysaccharide Biosynthesis Pathway 

      Wattam, Alice R.; Inzana, Thomas J.; Williams, Kelly P.; Mane, Shrinivasrao P.; Shukla, Maulik; Almeida, Nalvo F.; Dickerman, Allan W.; Mason, Steven; Moriyon, Ignacio; O'Callaghan, David; Whatmore, Adrian M.; Sobral, Bruno W.; Tiller, Rebekah V.; Hoffmaster, Alex R.; Frace, Michael A.; De Castro, Cristina; Molinaro, Antonio; Boyle, Stephen M.; De, Barun K.; Setubal, Joao C. (American Society for Microbiology, 2012-11)
      Brucella species are Gram-negative bacteria that infect mammals. Recently, two unusual strains (Brucella inopinata BO1T and B. inopinata-like BO2) have been isolated from human patients, and their similarity to some atypical ...
    • A History of the Development of Brucella Vaccines 

      Avila-Calderon, Eric Daniel; Lopez-Merino, Ahidé; Sriranganathan, Nammalwar; Boyle, Stephen M.; Contreras-Rodriguez, Araceli (Hindawi Publishing Corporation, 2013)
      Brucellosis is a worldwide zoonosis affecting animal and human health. In the last several decades, much research has been performed to develop safer Brucella vaccines to control the disease mainly in animals. Till now, ...
    • Molecular Surveillance of Viral Processes Using Silicon Nitride Membranes 

      Gilmore, Brian L.; Tanner, Justin R.; McKell, Allison O.; Boudreaux, Crystal E.; Dukes, Madeline J.; McDonald, Sarah M.; Kelly, Deborah F. (MDPI, 2013-03)
      Here we present new applications for silicon nitride (SiN) membranes to evaluate biological processes. We determined that 50-nanometer thin films of SiN produced from silicon wafers were sufficiently durable to bind active ...