Now showing items 1-20 of 106

    • Campylobacter jejuni - An emerging foodborne pathogen 

      Altekruse, Sean Fitzgerald; Stern, N. J.; Fields, P. I.; Swerdlow, David L. (1999-01)
      Campylobacter jejuni is the most commonly reported bacterial cause of foodborne infection in the United States. Adding to the human and economic costs are chronic sequelae associated with C. jejuni infection-Guillain-Barre ...
    • van der Waals and hygroscopic forces of adhesion generated by spider capture threads 

      Hawthorn, A. C.; Opell, B. D. (Company of Biologists Ltd., 2003-11)
      Cribellar thread is the most primitive type of sticky prey capture thread found in aerial spider webs. Its outer surface is formed of thousands of fine fibrils that issue from a cribellum spinning field. The fibrils of ...
    • Effects of antemortem ingestion of ethanol on insect successional patterns and development of Phormia regina (Diptera : Calliphoridae) 

      Tabor, Kimberly L.; Fell, Richard D.; Brewster, Carlyle C.; Pelzer, Kevin D.; Behonick, George S. (Oxford University Press, 2005-05-01)
      The effects of antemortem ingestion of ethanol by domestic pigs, Sus scrofa L., on postmortem insect successional patterns and the development of Phormia regina (Meigen) were studied during summer 2003 in Blacksburg, VA. ...
    • Molecular targets for rapid identification of Brucellaspp 

      Ratushna, Vladyslava G.; Sturgill, David M.; Ramamoorthy, Sheela; Reichow, Sherry A.; He, Yongqun; Lathigra, Raju; Sriranganathan, Nammalwar; Halling, Shirley M.; Boyle, Stephen M.; Gibas, Cynthia J. (2006-02-22)
      Background Brucella is an intracellular pathogen capable of infecting animals and humans. There are six recognized species of Brucella that differ in their host preference. The genomes of the three Brucella species have ...
    • PATRIC: The VBI PathoSystems Resource Integration Center 

      Snyder, E. E.; Kampanya, N.; Lu, J.; Nordberg, E. K.; Karur, H. R.; Shukla, Maulik; Soneja, J.; Tian, Y.; Xue, T.; Yoo, H.; Zhang, F.; Dharmanolla, C.; Dongre, N. V.; Gillespie, J. J.; Hamelius, J.; Hance, M.; Huntington, K. I.; Jukneliene, D.; Koziski, J.; Mackasmiel, L.; Mane, S. P.; Nguyen, V.; Purkayastha, A.; Shallom, J.; Yu, G.; Guo, Y.; Gabbard, Joseph L.; Hix, D.; Azad, A. F.; Baker, S. C.; Boyle, S. M.; Khudyakov, Y.; Meng, Xiang-Jin; Rupprecht, C.; Vinje, J.; Crasta, Oswald R.; Czar, M. J.; Dickerman, Allan W.; Eckart, J. D.; Kenyon, R.; Will, R.; Setubal, Joao C.; Sobral, Bruno (2007-01)
      The PathoSystems Resource Integration Center (PATRIC) is one of eight Bioinformatics Resource Centers (BRCs) funded by the National Institute of Allergy and Infection Diseases (NIAID) to create a data and analysis resource ...
    • A versatile computational pipeline for bacterial genome annotation improvement and comparative analysis, with Brucella as a use case 

      Yu, G. X.; Snyder, E. E.; Boyle, S. M.; Crasta, Oswald R.; Czar, M. J.; Mane, S. P.; Purkayastha, A.; Sobral, Bruno; Setubal, Joao C. (2007-06)
      We present a bacterial genome computational analysis pipeline, called GenVar. The pipeline, based on the program GeneWise, is designed to analyze an annotated genome and automatically identify missed gene calls and sequence ...
    • Enzymatic, immunological and phylogenetic characterization of Brucella suis urease 

      Contreras-Rodriguez, Araceli; Quiroz-Limon, Jose; Martins, Ana M.; Peralta, Humberto; Avila-Calderon, Eric Daniel; Sriranganathan, Nammalwar; Boyle, Stephen M.; Lopez-Merino, Ahidé (2008-07-19)
      Background The sequenced genomes of the Brucella spp. have two urease operons, ure-1 and ure-2, but there is evidence that only one is responsible for encoding an active urease. The present work describes the purification ...
    • In Situ Real-Time Chemiluminescence Imaging of Reactive Oxygen Species Formation from Cardiomyocytes 

      Li, Yunbo; Shen, Haiou; Zhu, Hong; Trush, Michael A.; Jiang, Ming; Wang, Ge (Hindawi, 2009-02-25)
      We have applied the highly sensitive chemiluminescence (CL) imagingtechnique to investigate the in situ ROS formation in cultured monolayers of rat H9c2 cardiomyocytes. Photon emission was detected via an innovative imaging ...
    • Incorporation of membrane-bound, mammalian-derived immunomodulatory proteins into influenza whole virus vaccines boosts immunogenicity and protection against lethal challenge 

      Herbert, Andrew S.; Heffron, C. Lynn; Sundick, Roy; Roberts, Paul C. (2009-04-24)
      Background Influenza epidemics continue to cause morbidity and mortality within the human population despite widespread vaccination efforts. This, along with the ominous threat of an avian influenza pandemic (H5N1), ...
    • Identification, Characterization and Immunogenicity of an O-Antigen Capsular Polysaccharide of Francisella tularensis 

      Apicella, Michael A.; Post, Deborah M. B.; Fowler, Andrew C.; Jones, Bradley D.; Rasmussen, Jed A.; Hunt, Jason R.; Imagawa, Sayaka; Choudhury, Biswa; Inzana, Thomas J.; Maier, Tamara M.; Frank, Dara W.; Zahrt, Thomas C.; Chaloner, Kathryn; Jennings, Michael P.; McLendon, Molly K.; Gibson, Bradford W. (PLOS, 2010-07-06)
      Capsular polysaccharides are important factors in bacterial pathogenesis and have been the target of a number of successful vaccines. Francisella tularensis has been considered to express a capsular antigen but none has ...
    • Tocopherol induced angiogenesis in placental vascular network in late pregnant ewes 

      Kasimanickam, Ramanathan K.; Kasimanickam, Vanmathy R.; Rodriguez, Jacobo S.; Pelzer, Kevin D.; Sponenberg, D. Phillip; Thatcher, Craig D. (2010-07-12)
      Background Tocopherols have biphasic, proangiogenic and antiangiogenic therapeutic effects. The objective of this clinical trial was to clarify tocopherol's placental angiogenic potential in late pregnant ewes following ...
    • Non-Thermal Irreversible Electroporation (N-TIRE) and Adjuvant Fractionated Radiotherapeutic Multimodal Therapy for Intracranial Malignant Glioma in a Canine Patient 

      Garcia, Paulo A.; Pancotto, Theresa E.; Rossmeisl, John H. Jr.; Henao-Guerrero, Natalia; Gustafson, N. R.; Daniel, Gregory B.; Robertson, John L.; Ellis, Thomas L.; Davalos, Rafael V. (Adenine Press, 2011-02-01)
      Non-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE ...
    • The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization. 

      Hughes-Fulford, Millie; Li, Chai-Fei (2011-02-09)
      Introduction The difficulty in re-growing and mineralizing new bone after severe fracture can result in loss of ambulation or limb. Here we describe the sequential roles of FGF-2 in inducing gene expression, cell growth ...
    • Horizontal gene transfer in Histophilus somni and its role in the evolution of pathogenic strain 2336, as determined by comparative genomic analyses 

      Siddaramappa, Shivakumara; Challacombe, Jean F.; Duncan, Alison J.; Gillaspy, Allison F.; Carson, Matthew; Gipson, Jenny; Orvis, Joshua; Zaitshik, Jeremy; Barnes, Gentry; Bruce, David; Chertkov, Olga; Detter, J. Chris; Han, Cliff S.; Tapia, Roxanne; Thompson, Linda S.; Dyer, David W.; Inzana, Thomas J. (2011-11-23)
      Background Pneumonia and myocarditis are the most commonly reported diseases due to Histophilus somni, an opportunistic pathogen of the reproductive and respiratory tracts of cattle. Thus far only a few genes involved in ...
    • Molecular epidemiology of hepatitis E virus infections in Shanghai, China 

      Zhu, Yumin; Si, Fusheng; Cao, Dianjun; Yu, Xiaoming; Yu, Ruisong; Dong, Shijuan; Huang, Fenfen; Zhang, Yuanshu; Li, Zhen (2011-12-15)
      Background Hepatitis E virus (HEV) causes acute or fulminant hepatitis in humans and is an important public health concern in many developing countries. China has a high incidence of HEV epidemics, with at least three ...
    • Characterization of Outer Membrane Vesicles from Brucella melitensis and Protection Induced in Mice 

      Avila-Calderon, Eric Daniel; Lopez-Merino, Ahidé; Jain, Neeta; Peralta, Humberto; Lopez-Villegas, Edgar Oliver; Sriranganathan, Nammalwar; Boyle, Stephen M.; Witonsky, Sharon G.; Contreras-Rodriguez, Araceli (Hindawi Publishing Corp, 2011-12-29)
      The outer membrane vesicles (OMVs) from smooth B. melitensis 16 M and a derived rough mutant, VTRM1 strain, were purified and characterized with respect to protein content and induction of immune responses in mice. Proteomic ...
    • Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it? 

      Cecere, Thomas E.; Todd, S. Michelle; LeRoith, Tanya (MDPI, 2012-05-01)
      Regulatory T cells (Tregs) are a subset of T cells that are responsible for maintaining peripheral immune tolerance and homeostasis. The hallmark of Tregs is the expression of the forkhead box P3 ...
    • A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T 

      Siddaramappa, Shivakumara; Challacombe, Jean F.; DeCastro, Rosana E.; Pfeiffer, Friedhelm; Sastre, Diego E.; Giménez, María I.; Paggi, Roberto A.; Detter, John C.; Davenport, Karen W.; Goodwin, Lynne A.; Kyrpides, Nikos; Tapia, Roxanne; Pitluck, Samuel; Lucas, Susan; Woyke, Tanja; Maupin-Furlow, Julie A. (2012-05-04)
      Background Natrialba magadii is an aerobic chemoorganotrophic member of the Euryarchaeota and is a dual extremophile requiring alkaline conditions and hypersalinity for optimal growth. The genome sequence of Nab. magadii ...
    • Risk Factors of Porcine Cysticercosis in the Eastern Cape Province, South Africa 

      Krecek, Rosina Claudia; Mohammed, Hamish; Michael, Lynne Margaret; Schantz, Peter Mullineaux; Ntanjana, Lulama; Morey, Liesl; Werre, Stephen R.; Willingham, Arve Lee, III (PLOS, 2012-05-24)
      There is a high prevalence of Taenia solium taeniosis/cysticercosis in humans and pigs in the Eastern Cape Province (ECP) of South Africa. The objective of this study was to identify risk factors of porcine cysticercosis ...
    • The role of lipooligosaccharide phosphorylcholine in colonization and pathogenesis of Histophilus somni in cattle 

      Elswaifi, Shaadi F.; Scarratt, W. Kent; Inzana, Thomas J. (Biomed Central Ltd, 2012-06-07)
      Histophilus somni is a Gram-negative bacterium and member of the Pasteurellaceae that is responsible for respiratory disease and other systemic infections in cattle. One of the bacterium’s virulence factors is antigenic ...