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Now showing items 25-44 of 590

    • BDNF Val(66)Met Polymorphism Influences Visuomotor Associative Learning and the Sensitivity to Action Observation 

      Taschereau-Dumouchel, Vincent; Hetu, Sebastien; Michon, Pierre-Emmanuel; Vachon-Presseau, Etienne; Massicotte, Elsa; De Beaumont, Louis; Fecteau, Shirley; Poirier, Judes; Mercier, Catherine; Chagnon, Yvon C.; Jackson, Philip L. (Springer Nature, 2016-10-05)
      Motor representations in the human mirror neuron system are tuned to respond to specific observed actions. This ability is widely believed to be influenced by genetic factors, but no study has reported a genetic variant ...
    • BDNF Val(66)Met Polymorphism Is Associated with Self-Reported Empathy 

      Taschereau-Dumouchel, Vincent; Hetu, Sebastien; Bagramian, Anait; Labrecque, Alexandre; Racine, Marion; Chagnon, Yvon C.; Jackson, Philip L. (PLOS, 2016-02-12)
      Empathy is an important driver of human social behaviors and presents genetic roots that have been studied in neuroimaging using the intermediate phenotype approach. Notably, the Val66Met polymorphism of the Brain-derived ...
    • Beginning A Patient-Centered Approach in the Design of A Diabetes Prevention Program 

      Seidel, Richard W.; Pardo, Kimberlee A.; Estabrooks, Paul A.; You, Wen; Wall, Sarah S.; Davy, Brenda M.; Almeida, Fabio A. (Mdpi Ag, 2014-02-01)
    • Behavioral and TMS Markers of Action Observation Might Reflect Distinct Neuronal Processes 

      Hétu, Sébastien; Taschereau-Dumouchel, Vincent; Meziane, Hadj Boumediene; Jackson, Philip L.; Mercier, Catherine (Frontiers Media S.A., 2016-09-14)
      Transcranial magnetic stimulation (TMS) studies have shown that observing an action induces muscle-specific changes in corticospinal excitability. From a signal detection theory standpoint, this pattern can be related to ...
    • Belief about nicotine modulates subjective craving and insula activity in deprived smokers 

      Gu, Xiaosi; Lohrenz, Terry; Salas, Ramiro; Baldwin, Philip R.; Soltani, Alireza; Kirk, Ulrich; Cinciripini, Paul M.; Montague, P. Read (Frontiers, 2016-07-13)
      Little is known about the specific neural mechanisms through which cognitive factors influence craving and associated brain responses, despite the initial success of cognitive therapies in treating drug addiction. In this ...
    • Belief about nicotine selectively modulates value and reward prediction error signals in smokers 

      Gu, Xiaosi; Lohrenz, Terry; Salas, Ramiro; Baldwin, Philip R.; Soltani, Alireza; Kirk, Ulrich; Cinciripini, Paul M.; Montague, P. Read (NAS, 2015-02-24)
      Little is known about how prior beliefs impact biophysically described processes in the presence of neuroactive drugs, which presents a profound challenge to the understanding of the mechanisms and treatments of addiction. ...
    • The Betrayal Aversion Elicitation Task: An Individual Level Betrayal Aversion Measure 

      Aimone, Jason; Ball, Sheryl B.; King-Casas, Brooks (PLOS, 2015-09-02)
      Research on betrayal aversion shows that individuals’ response to risk depends not only on probabilities and payoffs, but also on whether the risk includes a betrayal of trust. While previous studies focus on measuring ...
    • Biosensor Approach to Psychopathology Classification 

      Koshelev, Misha; Lohrenz, Terry; Vannucci, Marina; Montague, P. Read (PLOS, 2010-10-21)
      We used a multi-round, two-party exchange game in which a healthy subject played a subject diagnosed with a DSM-IV (Diagnostic and Statistics Manual-IV) disorder, and applied a Bayesian clustering approach to the behavior ...
    • Blood Vessel Patterning on Retinal Astrocytes Requires Endothelial Flt-1 (VEGFR-1) 

      Chappell, John C.; Darden, Jordan; Payne, Laura Beth; Fink, Kathryn; Bautch, Victoria L. (MDPI, 2019-09-07)
      Feedback mechanisms are critical components of many pro-angiogenic signaling pathways that keep vessel growth within a functional range. The Vascular Endothelial Growth Factor-A (VEGF-A) pathway utilizes the decoy VEGF-A ...
    • BOLD responses to negative reward prediction errors in human habenula 

      Salas, Ramiro; Baldwin, Philip; Biasi, Mariella de; Montague, P. Read (Frontiers, 2010-05-11)
      Although positive reward prediction error, a key element in learning that is signaled by dopamine cells, has been extensively studied, little is known about negative reward prediction errors in humans. Detailed animal ...
    • A CACNA1C Variant Associated with Reduced Voltage-Dependent Inactivation, Increased Ca(V)1.2 Channel Window Current, and Arrhythmogenesis 

      Hennessey, Jessica A.; Boczek, Nicole J.; Jiang, Yong-Hui; Miller, Joelle D.; Patrick, William; Pfeiffer, Ryan; Sutphin, Brittan S.; Tester, David J.; Barajas-Martinez, Hector; Ackerman, Michael J.; Antzelevitch, Charles; Kanter, Ronald; Pitt, Geoffrey S. (PLOS, 2014-09-03)
      Mutations in CACNA1C that increase current through the CaV1.2 L-type Ca2+ channel underlie rare forms of long QT syndrome (LQTS), and Timothy syndrome (TS). We identified a variant in CACNA1C in a male child of Filipino ...
    • Capsular Polysaccharide Interferes with Biofilm Formation by Pasteurella multocida Serogroup A 

      Petruzzi, Briana; Briggs, Robert E.; Swords, W. Edward; De Castro, Cristina; Molinaro, Antonio; Inzana, Thomas J. (American Society for Microbiology, 2017-11)
      Pasteurella multocida is an important multihost animal and zoonotic pathogen that is capable of causing respiratory and multisystemic diseases, bacteremia, and bite wound infections. The glycosaminoglycan capsule of P. ...
    • Capturing Enveloped Viruses on Affinity Grids for Downstream Cryo- Electron Microscopy Applications 

      Kiss, G.; Chen, X. M.; Brindley, M. A.; Campbell, P.; Afonso, C. L.; Ke, Z. L.; Holl, J. M.; Guerrero-Ferreira, R. C.; Byrd-Leotis, L. A.; Steel, J.; Steinhauer, D. A.; Plemper, R. K.; Kelly, Deborah F.; Spearman, P. W.; Wright, E. R. (Cambridge University Press, 2014-02)
      Electron microscopy (EM), cryo-electron microscopy (cryo-EM), and cryo-electron tomography (cryo-ET) are essential techniques used for characterizing basic virus morphology and determining the three-dimensional structure ...
    • Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science 

      Sorrentino, Dario; Nguyen, Vu Q.; Chitnavis, Maithili V. (MDPI, 2019-06-06)
      While much progress has been made in the last two decades in the treatment and the management of inflammatory bowel diseases (IBD)—both ulcerative colitis (UC) and Crohn’s Disease (CD)—as of today these ...
    • The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats 

      Allen, Mitchell E.; Pennington, Edward Ross; Perry, Justin B.; Dadoo, Sahil; Makrecka-Kuka, Marina; Dambrova, Maija; Moukdar, Fatiha; Patel, Hetal D.; Han, Xianlin; Kidd, Grahame K.; Benson, Emily K.; Raisch, Tristan B.; Poelzing, Steven; Brown, David A.; Shaikh, Saame Raza (2020-07-17)
      Allen and Pennington et al. show that the cardiolipin-binding peptide elamipretide mitigates disease-induced fragmentation of cristae networks following cardiac ischemia reperfusion in rats. This study suggests that ...
    • A Case of Cachexia Secondary to Obsessive-Compulsive Disorder 

      Gosnell, Hailey L.; Kablinger, Anita S. (Hindawi, 2020-05-27)
      Obsessive-compulsive disorder (OCD), a relatively common psychiatric illness, is diagnosed using DSM-V criteria. Its severity is assessed using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Symptoms are broken down ...
    • A case series of endemic infections associated hemophagocytic lymphohistiocytosis (HLH) mimicking severe sepsis syndrome 

      Kollipara, Venkateswara; Hussain, Shahzad; Franco-Palacios; Sofi, Umar (Elsevier, 2019-05-06)
      Hemophagocytic lymphohistiocytosis (HLH) is associated to high mortality and morbidity. A condition often underrecognized, HLH should be in the differential diagnosis of patients presenting with fever, cytopenia, ...
    • Case study on the use of intensive pediatric neurorehabilitation in the treatment of kernicterus 

      Mann, Jessie; Wallace, Dory A.; DeLuca, Stephanie (2020-02-03)
      Background Kernicterus Spectrum Disorder (KSD) is the result of prolonged bilirubin toxicity resulting in widespread neurological injury. Once the bilirubin levels are normalized the encephalopathy becomes static, however ...
    • Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival 

      Varghese, Robin T.; Young, Sarah; Pham, Lily; Liang, Yanping; Pridham, Kevin J.; Guo, Sujuan; Murphy, Susan; Kelly, Deborah F.; Sheng, Zhi (Nature, 2018-09-11)
      Glioblastoma is the most common malignant brain cancer with a dismal prognosis. The difficulty in treating glioblastoma is largely attributed to the lack of effective therapeutic targets. In our previous work, we identified ...
    • Cell Cycle Model System for Advancing Cancer Biomarker Research 

      Lazar, Iulia M.; Hoeschele, Ina; de Morais, Juliana; Tenga, Milagros J. (Springer Nature, 2017-12-21)
      Progress in understanding the complexity of a devastating disease such as cancer has underscored the need for developing comprehensive panels of molecular markers for early disease detection and precision medicine applications. ...