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Multiple Retinal Axons Converge onto Relay Cells in the Adult Mouse Thalamus
(Cell, 2015)
Activity-dependent refinement of neural circuits is a fundamental principle of neural development. This process has been well studied at retinogeniculate synapses—synapses that form between retinal ganglion cells (RGCs) ...
F-spondin Is Essential for Maintaining Circadian Rhythms
(Frontiers, 2018-02-08)
The suprachiasmatic nucleus (SCN) is the master pacemaker that drives circadian behaviors. SCN neurons have intrinsic, self-sustained rhythmicity that is governed by transcription-translation feedback loops. Intrinsic ...
Developmental remodeling of relay cells in the dorsal lateral geniculate nucleus in the absence of retinal input
(BMC, 2015)
Background: The dorsal lateral geniculate nucleus (dLGN) of the mouse has been an important experimental model for understanding thalamic circuit development. The developmental remodeling of retinal projections has been ...
Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice
(Hindawi, 2012)
The cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR). Recent findings indicate that the ...
Nuclei-specific differences in nerve terminal distribution, morphology, and development in mouse visual thalamus
(BMC, 2014)
Background: Mouse visual thalamus has emerged as a powerful model for understanding the mechanisms underlying neural circuit formation and function. Three distinct nuclei within mouse thalamus receive retinal input, the ...
Optic Nerve Hypoplasia Is a Pervasive Subcortical Pathology of Visual System in Neonates
(ARVO, 2017-11)
PURPOSE. Optic nerve hypoplasia (ONH) is the most common cause of childhood congenital blindness in developed nations, yet the fundamental pathobiology of ONH remains unknown. The objective of this study was to employ a ...
LRRTM1 underlies synaptic convergence in visual thalamus
(eLife, 2018-02-09)
It has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted ...
Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections
(BioMed Central, 2013-06-13)
Background: Retinal ganglion cells (RGCs), the output neurons of the retina, project to over 20 distinct brain nuclei, including the lateral geniculate nucleus (LGN), a thalamic region comprised of three functionally ...
Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus
(2019-02-14)
DNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in understanding the maturation ...
Non-Cell Autonomous Roles for CASK in Optic Nerve Hypoplasia
(ARVO, 2019)
PURPOSE. Heterozygous mutations in the essential X-linked gene CASK associate with optic nerve hypoplasia (ONH) and other retinal disorders in girls. CASKþ/ heterozygous knockout mice with mosaic CASK expression exhibit ...