Now showing items 1-10 of 320
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
Connexin 43 (Cx43) is a gap junction (GJ) protein widely expressed in mammalian tissues that mediates cell-to-cell coupling. Intercellular channels comprising GJ aggregates form from docking of paired connexons, with one ...
Impact of the controlled release of a connexin 43 peptide on corneal wound closure in an STZ model of type I diabetes.
The alpha-carboxy terminus 1 (αCT1) peptide is a synthetically produced mimetic modified from the DDLEI C-terminus sequence of connexin 43 (Cx43). Previous research using various wound healing models have found promising ...
Inputs to prefrontal cortex support visual recognition in the aging brain
(Scientific Reports, 2016-08-23)
Predictive coding models of brain function propose that top-down cortical signals promote efficient neural codes by carrying predictions of upcoming sensory events. We hypothesized that older brains would employ these codes ...
The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress
There is increased recognition that sensory neurons located in dorsal root ganglia (DRG) are affected in amyotrophic lateral sclerosis (ALS). However, it remains unknown whether ALS-inducing factors, other than mutant ...
(Virginia Tech, 2015-08)
*(Faculty Resources for Educational Excellence)
The Functional Architecture of the Brain Underlies Strategic Deception in Impression Management
Impression management, as one of the most essential skills of social function, impacts one’s survival and success in human societies. However, the neural architecture underpinning this social skill remains poorly understood. ...
MRSA USA300 at Alaska native medical center, Anchorage, Alaska, USA, 2000-2006
(Centers for Disease Control and Prevention, 2012-01)
To determine whether methicillin-resistant Staphylococcus aureus (MRSA) USA300 commonly caused infections among Alaska Natives, we examined clinical MRSA isolates from the Alaska Native Medical Center, Anchorage, during ...
A large-scale RNA interference screen identifies genes that regulate autophagy at different stages
(Nature Publishing Group, 2018-02-12)
Dysregulated autophagy is central to the pathogenesis and therapeutic development of cancer. However, how autophagy is regulated in cancer is not well understood and genes that modulate cancer autophagy are not fully ...
Methicillin-Susceptible Staphylococcus aureus as a Predominantly Healthcare-Associated Pathogen: A Possible Reversal of Roles?
<p>Background<br> Methicillin-resistant Staphylococcus aureus (MRSA) strains have become common causes of skin and soft tissue infections (SSTI) among previously healthy people, a role of methicillin-susceptible (MSSA) ...
Hand and Nasal Carriage of Discordant Staphylococcus aureus Isolates among Urban Jail Detainees
(American Society for Microbiology, 2014-09)
In 928 Dallas County Jail detainees, nasal carriage of Staphylococcus aureus was found in 32.8% (26.5% methicillin-susceptible Staphylococcus aureus [MSSA] and 6.3% methicillin-resistant S. aureus [MRSA]), and hand carriage ...