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Low Dose Infliximab for Prevention of Postoperative Recurrence of Crohn's Disease: Long Term Follow-Up and Impact of Infliximab Trough Levels and Antibodies to Infliximab
(PLOS, 2015-12-15)
Objective
In patients with postoperative recurrence of Crohn’s disease endoscopic and clinical remission can be maintained for up to 1 year with low infliximab doses (3 mg/Kg). However, in theory low-dose infliximab ...
A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease
(Springer Nature, 2015-09-23)
We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable adaptor molecules to select ...
Capturing Enveloped Viruses on Affinity Grids for Downstream Cryo- Electron Microscopy Applications
(Cambridge University Press, 2014-02)
Electron microscopy (EM), cryo-electron microscopy (cryo-EM), and cryo-electron tomography (cryo-ET) are essential techniques used for characterizing basic virus morphology and determining the three-dimensional structure ...
Functional and cognitive status in Clostridium difficile infection in the hospitalized elderly: A Retrospective Study of Two Sites
(Springer, 2019-03-20)
Advanced age is a risk factor for Clostridium difficile infection (CDI), and older patients have more severe CDI and worse outcome [1-3]. We investigated whether CDI in the elderly is associated with functional and cognitive ...
Visualizing Nanoparticle Mobility in Liquid at Atomic Resolution
(The Royal Society of Chemistry, 2013-02-28)
Gold nanorods are widely known for their photothermal properties to treat solid tumors. Our work demonstrates the unrealized capacity to image these reagents in liquid at high resolution using Transmission Electron Microscopy ...
Neuroeconomic Measures of Social Decision-Making Across the Lifespan
(Frontiers Media S.A., 2012-09-21)
Social and decision-making deficits are often the first symptoms of a striking number of neurodegenerative disorders associated with aging. These includes not only disorders that directly impact dopamine and basal ganglia, ...
Opening the Debate: How to Fulfill the Need for Physicians’ Training in Circadian-Related Topics in a Full Medical School Curriculum
(Ubiquity Press, 2015)
Background: Circadian rhythms are daily changes in our physiology and behavior that are manifested as patterns of brain wave activity, periodic hormone production, recurring cell regeneration, and other oscillatory biological ...
The Reliability and Validity of the Loadsol® under Various Walking and Running Conditions
(MDPI, 2019-01-11)
The assessment of loading during walking and running has historically been limited to data collection in laboratory settings or with devices that require a computer connection. This study aims to determine if the ...
`Changing Minds’: determining the effectiveness and key ingredients of an educational intervention to enhance healthcare professionals’ intentions to prescribe physical activity to patients with physical disabilities
(2014-03-01)
Background
Healthcare professionals (HCPs) are vital conduits of leisure-time physical activity (LTPA) information; however, few discuss LTPA with their patients with disabilities. ‘Changing Minds, Changing Lives’ (CMCL) ...
Transudative chylothorax in a patient with lymphangioleiomyomatosis
(Elsevier, 2017-09-30)
Transudative chylothorax is a rare type of pleural effusion. It has been described to be present in the setting of liver cirrhosis, heart failure, amyloidosis, nephrotic syndrome, superior vena cava thrombosis, sclerosing ...