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Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy.
(2010-05-07)
BACKGROUND: The Notch receptor links cell fate decisions of one cell to that of the immediate cellular neighbor. In humans, malfunction of Notch signaling results in diseases and congenital disorders. Structural information ...
A novel frequency analysis method for assessing K(ir)2.1 and Na (v)1.5 currents.
(2012-04)
Voltage clamping is an important tool for measuring individual currents from an electrically active cell. However, it is difficult to isolate individual currents without pharmacological or voltage inhibition. Herein, we ...
Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration.
(2015-05-10)
Impaired expression of connexins, the gap junction subunits that facilitate direct cell-cell communication, have been implicated in prostate cancer growth. To elucidate the crucial role of connexins in prostate cancer ...
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
(2011-05)
Connexin 43 (Cx43) is a gap junction (GJ) protein widely expressed in mammalian tissues that mediates cell-to-cell coupling. Intercellular channels comprising GJ aggregates form from docking of paired connexons, with one ...
The effect of a connexin43-based Peptide on the healing of chronic venous leg ulcers: a multicenter, randomized trial.
(2015-01)
The gap junction protein, connexin43 (Cx43), has critical roles in the inflammatory, edematous, and fibrotic processes following dermal injury and during wound healing, and is abnormally upregulated at the epidermal wound ...
The Latent Structure of Interpersonal Problems: Validity of Dimensional, Categorical, and Hybrid Models
(American Psychological Association, 2019-11-01)
Interpersonal problems are key transdiagnostic constructs in psychopathology. In the past, investigators have neglected the importance of operationalizing interpersonal problems according to their latent structure by using ...
Choice bundling, unpacked: Predicted and observed effects on intertemporal choice in an additive model of hyperbolic delay discounting
(PLoS, 2021-11-12)
One method known to increase preference for larger, later rewards (LLRs) over smaller, sooner rewards (SSRs) is choice bundling, in which a single choice produces a series of repeating consequences over time. The present ...
Triangulating abuse liability assessment for flavoured cigar products using physiological, behavioural economic and subjective assessments: a within-subjects clinical laboratory protocol
(BMJ, 2018-10-01)
Introduction In the USA, Food and Drug Administration regulations prohibit the sale of flavoured cigarettes, with menthol being the exception. However, the manufacture, advertisement and sale of flavoured cigar products ...
Dosing parameters for the effects of high-frequency transcranial magnetic stimulation on smoking cessation: Study protocol for a randomized factorial sham-controlled clinical trial
(Springer, 2020-05-01)
Background: Despite the considerable success of comprehensive tobacco control efforts, tobacco use remains one of the greatest preventable causes of death and disease today. Over half of all smokers in the US make quit ...
Using a human factors-centric approach to development and testing of a face shield designed for health care workers: A COVID-19 case study for process and outcomes
(Mosby-Elsevier, 2022-03-01)
Background: Face shields are a critical piece of personal protective equipment and their comfort impacts compliant use and thus protectiveness. Optimal design criteria for face shield use in healthcare environments are ...