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In Cocaine Dependence, Neural Prediction Errors During Loss Avoidance Are Increased With Cocaine Deprivation and Predict Drug Use
(Elsevier, 2018-08-03)
Background: In substance-dependent individuals, drug deprivation and drug use trigger divergent behavioral responses to environmental cues. These divergent responses are consonant with data showing that short- and long-term ...
Belief about nicotine modulates subjective craving and insula activity in deprived smokers
(Frontiers, 2016-07-13)
Little is known about the specific neural mechanisms through which cognitive factors influence craving and associated brain responses, despite the initial success of cognitive therapies in treating drug addiction. In this ...
Belief about nicotine selectively modulates value and reward prediction error signals in smokers
(NAS, 2015-02-24)
Little is known about how prior beliefs impact biophysically described processes in the presence of neuroactive drugs, which presents a profound challenge to the understanding of the mechanisms and treatments of addiction. ...
Interoception drives increased rational decision-making in meditators playing the ultimatum game
(Frontiers, 2011-04-18)
Human decision-making is often conceptualized as a competition between cognitive and emotional processes in the brain. Deviations from rational processes are believed to derive from inclusion of emotional factors in ...
Neuroimaging after mild traumatic brain injury: Review and meta-analysis
(Elsevier, 2014-01-04)
This paper broadly reviews the study of mild traumatic brain injury (mTBI), across the spectrum of neuroimaging modalities. Among the range of imaging methods, however, magnetic resonance imaging (MRI) is unique in its ...
A computational approach to “free will” constrained by the games we play
(Frontiers, 2012-09-27)
Human choice is not free—we are bounded by a multitude of biological constraints. Yet, within the various landscapes we face, we do express choice, preference, and varying degrees of so-called willful behavior. Moreover, ...
BOLD responses to negative reward prediction errors in human habenula
(Frontiers, 2010-05-11)
Although positive reward prediction error, a key element in learning that is signaled by dopamine cells, has been extensively studied, little is known about negative reward prediction errors in humans. Detailed animal ...
Aging into Perceptual Control: A Dynamic Causal Modeling for fMRI Study of Bistable Perception
(Frontiers, 2016-03-31)
Aging is accompanied by stereotyped changes in functional brain activations, for example a cortical shift in activity patterns from posterior to anterior regions is one hallmark revealed by functional magnetic resonance ...
Functional brain network changes associated with maintenance of cognitive function in multiple sclerosis
(Frontiers, 2010-11-22)
In multiple sclerosis (MS) functional changes in connectivity due to cortical reorganization could lead to cognitive impairment (CI), or reflect a re-adjustment to reduce the clinical effects of widespread tissue damage. ...
Predictability Modulates Human Brain Response to Reward
(Society for Neuroscience, 2001-04-15)
Certain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of ...